Transketolase [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Full Name: Transketolase
Primary source: TAIR:AT3G60750
Locus tag: AT3G60750
See related: Araport:AT3G60750
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AtTKL1; TKL1; transketolase 1
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Genomic context

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See in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 7

Sequence:: Chromosome: 3; NC_003074.8 (22453668..22457458)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results reveal the crucial importance of the level of transketolase activity to provide the precursor for synthesis of intermediates and to enable plants to produce thiamine and thiamine pyrophosphate for growth and development.
Title: Overexpression of plastid transketolase in tobacco results in a thiamine auxotrophic phenotype.
Results of the present study point to a role for transketolase (TKL) phosphorylation in the regulation of carbon allocation.
Title: Phosphorylation of Arabidopsis transketolase at Ser428 provides a potential paradigm for the metabolic control of chloroplast carbon metabolism.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_001203216.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transketolase activity	IDA Inferred from Direct Assay more info	PubMed
enables transketolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in reductive pentose-phosphate cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
is_active_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in chloroplast envelope	HDA more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
is_active_in chloroplast stroma	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
NOT located_in cytosol	RCA inferred from Reviewed Computational Analysis more info	PubMed
located_in plastid	HDA more info	PubMed

General protein information

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Preferred Names: Transketolase

NP_001190145.1

Transketolase; FUNCTIONS IN: catalytic activity, transketolase activity; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Transketolase, N-terminal (InterPro:IPR005474), Transketolase, C-terminal (InterPro:IPR005476), Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II (InterPro:IPR009014), Transketolase-like, pyrimidine-binding domain (InterPro:IPR005475), Transketolase binding site (InterPro:IPR020826), Transketolase, bacterial-like (InterPro:IPR005478), Transketolase-like, C-terminal (InterPro:IPR015941); BEST Arabidopsis thaliana protein match is: Transketolase (TAIR:AT2G45290.1).

NP_567103.1

Transketolase; FUNCTIONS IN: catalytic activity, transketolase activity; INVOLVED IN: response to cadmium ion, response to salt stress; LOCATED IN: chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: Transketolase, bacterial-like (InterPro:IPR005478), Transketolase, N-terminal (InterPro:IPR005474), Transketolase, C-terminal (InterPro:IPR005476), Transketolase-like, C-terminal (InterPro:IPR015941), Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II (InterPro:IPR009014), Transketolase-like, pyrimidine-binding domain (InterPro:IPR005475), Transketolase binding site (InterPro:IPR020826); BEST Arabidopsis thaliana protein match is: Transketolase (TAIR:AT2G45290.1); Has 19296 Blast hits to 19203 proteins in 2759 species: Archae - 202; Bacteria - 11440; Metazoa - 321; Fungi - 314; Plants - 204; Viruses - 0; Other Eukaryotes - 6815 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

22453668..22457458

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_115939.3 → NP_567103.1 Transketolase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567103.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B9DGH8, Q84WI5, Q8LE99, Q8RWV0, Q944P9, Q9LZY8

UniProtKB/TrEMBL

A0A178VEI0, A0A5S9XPC9

Conserved Domains (1) summary

PLN02790
Location:88 → 740

PLN02790; transketolase
NM_001203216.2 → NP_001190145.1 Transketolase [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_001190145.1

Status: REVIEWED

UniProtKB/TrEMBL

F4JBY2

Conserved Domains (4) summary

cd07033
Location:434 → 597

TPP_PYR_DXS_TK_like; Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins

PLN02790
Location:88 → 739

PLN02790; transketolase

pfam00456
Location:83 → 413

Transketolase_N; Transketolase, thiamine diphosphate binding domain

pfam02780
Location:627 → 732

Transketolase_C; Transketolase, C-terminal domain