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    IREG2 iron regulated 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831787, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IREG2
    Official Full Name
    iron regulated 2
    Primary source
    TAIR:AT5G03570
    Locus tag
    AT5G03570
    See related
    Araport:AT5G03570
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA IRON-REGULATED PROTEIN 2; ATIREG2; F12E4.370; F12E4_370; FERROPORTIN 2; FPN2; iron regulated 2
    Summary
    Encodes FPN2, a tonoplast localized nickel transport protein. FPN2 is one of the Arabidopsis orthologs (AT2G38460/IREG1/FPN1 and AT5G03570/IREG2/FPN2) the iron efflux transporter ferroportin (FPN) identified in animals.
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    Genomic context

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    See IREG2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    9
    Sequence:
    Chromosome: 5; NC_003076.8 (903470..906833)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene permease, cytosine/purines, uracil, thiamine, allantoin family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis. Morrissey J, et al. Plant Cell, 2009 Oct. PMID 19861554, Free PMC Article
    2. AtIREG2 encodes a tonoplast transport protein involved in iron-dependent nickel detoxification in Arabidopsis thaliana roots. Schaaf G, et al. J Biol Chem, 2006 Sep 1. PMID 16790430
    3. A user-friendly platform for yeast two-hybrid library screening using next generation sequencing. Erffelinck ML, et al. PLoS One, 2018. PMID 30576311, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fpn2 function in iron and cobalt homeostasis in Arabidopsis.
      Title: The ferroportin metal efflux proteins function in iron and cobalt homeostasis in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203288.1
    NM_001342717.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cobalt ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables iron ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables nickel cation transmembrane transporter activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to iron ion starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cobalt ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within detoxification of cobalt ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within iron ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nickel cation transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nickel cation transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within transition metal ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plant-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    iron regulated 2
    NP_001190217.1
    • iron regulated 2 (IREG2); CONTAINS InterPro DOMAIN/s: Ferroporti-1 (InterPro:IPR009716), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: iron regulated 1 (TAIR:AT2G38460.1).
    NP_195977.2
    • iron regulated 2 (IREG2); CONTAINS InterPro DOMAIN/s: Ferroporti-1 (InterPro:IPR009716), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: iron regulated 1 (TAIR:AT2G38460.1); Has 410 Blast hits to 334 proteins in 106 species: Archae - 0; Bacteria - 50; Metazoa - 178; Fungi - 61; Plants - 98; Viruses - 0; Other Eukaryotes - 23 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      903470..906833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120438.4 → NP_195977.2  iron regulated 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_195977.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KGN5, Q9LZC8
      UniProtKB/TrEMBL
      A0A7G2F6Z4
      Conserved Domains (1) summary
      pfam06963
      Location:31 → 479
      FPN1; Ferroportin1 (FPN1)

    2. NM_001342716.1 → NP_001332410.1  iron regulated 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BGV1, A0A654FXX9

    3. NM_001203288.1 → NP_001190217.1  iron regulated 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190217.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KGN5, Q9LZC8
      UniProtKB/TrEMBL
      A0A7G2F6Z4
      Conserved Domains (1) summary
      pfam06963
      Location:31 → 479
      FPN1; Ferroportin1 (FPN1)

    4. NM_001342717.1 → NP_001332409.1  iron regulated 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BGU8, A0A7G2F6Z4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4KGN5.1

    Gene LinkOut

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