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    PMDH2 peroxisomal NAD-malate dehydrogenase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830825, updated on 18-Sep-2024

    Summary

    Official Symbol
    PMDH2
    Official Full Name
    peroxisomal NAD-malate dehydrogenase 2
    Primary source
    TAIR:AT5G09660
    Locus tag
    AT5G09660
    See related
    Araport:AT5G09660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F17I14.150; F17I14_150; peroxisomal NAD-malate dehydrogenase 2
    Summary
    encodes a microbody NAD-dependent malate dehydrogenase encodes an peroxisomal NAD-malate dehydrogenase that is involved in fatty acid beta-oxidation through providing NAD to the process of converting fatty acyl CoA to acetyl CoA.
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    Genomic context

    See PMDH2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (2993411..2995784, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene serine carboxypeptidase-like 19 Neighboring gene pyrophosphorylase 6 Neighboring gene tRNA-Val Neighboring gene loricrin-like protein Neighboring gene reduced lateral root formation Neighboring gene magnesium transporter 7

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    NM_001036783.1
    NM_001085087.2
    NM_001125727.1
    NM_001343054.1
    NM_121003.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables L-malate dehydrogenase (NAD+) activity  
    enables malate dehydrogenase activity PubMed 

    General protein information

    Preferred Names
    peroxisomal NAD-malate dehydrogenase 2
    NP_001031860.1
    • peroxisomal NAD-malate dehydrogenase 2 (PMDH2); FUNCTIONS IN: malate dehydrogenase activity; INVOLVED IN: regulation of fatty acid beta-oxidation, regulation of photorespiration; LOCATED IN: apoplast, chloroplast, peroxisome, vacuole, microbody; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), Malate dehydrogenase, NAD-dependent, eukaryote/gamma proteobacteria (InterPro:IPR010097), NAD(P)-binding domain (InterPro:IPR016040), L-lactate/malate dehydrogenase (InterPro:IPR001557), Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: peroxisomal NAD-malate dehydrogenase 1 (TAIR:AT2G22780.1); Has 17207 Blast hits to 17205 proteins in 5456 species: Archae - 235; Bacteria - 12094; Metazoa - 1213; Fungi - 536; Plants - 740; Viruses - 0; Other Eukaryotes - 2389 (source: NCBI BLink).
    NP_001078556.1
    • peroxisomal NAD-malate dehydrogenase 2 (PMDH2); FUNCTIONS IN: malate dehydrogenase activity; INVOLVED IN: regulation of fatty acid beta-oxidation, regulation of photorespiration; LOCATED IN: apoplast, chloroplast, peroxisome, microbody; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), Malate dehydrogenase, NAD-dependent, eukaryote/gamma proteobacteria (InterPro:IPR010097), NAD(P)-binding domain (InterPro:IPR016040), L-lactate/malate dehydrogenase (InterPro:IPR001557), Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: peroxisomal NAD-malate dehydrogenase 1 (TAIR:AT2G22780.1); Has 16823 Blast hits to 16821 proteins in 5415 species: Archae - 235; Bacteria - 11979; Metazoa - 1199; Fungi - 507; Plants - 555; Viruses - 0; Other Eukaryotes - 2348 (source: NCBI BLink).
    NP_001119199.1
    • peroxisomal NAD-malate dehydrogenase 2 (PMDH2); FUNCTIONS IN: malate dehydrogenase activity; INVOLVED IN: regulation of fatty acid beta-oxidation, regulation of photorespiration; LOCATED IN: apoplast, chloroplast, peroxisome, microbody; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), Malate dehydrogenase, NAD-dependent, eukaryote/gamma proteobacteria (InterPro:IPR010097), NAD(P)-binding domain (InterPro:IPR016040), L-lactate/malate dehydrogenase (InterPro:IPR001557), Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: peroxisomal NAD-malate dehydrogenase 1 (TAIR:AT2G22780.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_196528.1
    • peroxisomal NAD-malate dehydrogenase 2 (PMDH2); FUNCTIONS IN: malate dehydrogenase activity; INVOLVED IN: regulation of fatty acid beta-oxidation, regulation of photorespiration; LOCATED IN: in 6 components; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Lactate/malate dehydrogenase, N-terminal (InterPro:IPR001236), Lactate/malate dehydrogenase, C-terminal (InterPro:IPR022383), NAD(P)-binding domain (InterPro:IPR016040), Malate dehydrogenase, NAD-dependent, eukaryote/gamma proteobacteria (InterPro:IPR010097), L-lactate/malate dehydrogenase (InterPro:IPR001557), Malate dehydrogenase, active site (InterPro:IPR001252), Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal (InterPro:IPR015955); BEST Arabidopsis thaliana protein match is: peroxisomal NAD-malate dehydrogenase 1 (TAIR:AT2G22780.1); Has 17070 Blast hits to 17068 proteins in 5416 species: Archae - 235; Bacteria - 12016; Metazoa - 1211; Fungi - 533; Plants - 741; Viruses - 0; Other Eukaryotes - 2334 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2993411..2995784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121003.4 → NP_196528.1  peroxisomal NAD-malate dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196528.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93ZA7, Q9ZP05
      UniProtKB/TrEMBL
      A0A178UMW0, A0A5S9Y2S0
      Conserved Domains (1) summary
      PLN00106
      Location:31 → 347
      PLN00106; malate dehydrogenase
    2. NM_001343054.1 → NP_001330735.1  peroxisomal NAD-malate dehydrogenase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BBQ0
    3. NM_001125727.1 → NP_001119199.1  peroxisomal NAD-malate dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119199.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H560
      Conserved Domains (2) summary
      cd01337
      Location:43 → 301
      MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases
      PLN00106
      Location:31 → 300
      PLN00106; malate dehydrogenase
    4. NM_001085087.2 → NP_001078556.1  peroxisomal NAD-malate dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078556.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8MRP1
      Conserved Domains (2) summary
      cd01337
      Location:22 → 280
      MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases
      PLN00106
      Location:10 → 279
      PLN00106; malate dehydrogenase
    5. NM_001036783.1 → NP_001031860.1  peroxisomal NAD-malate dehydrogenase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4KDZ4
      Conserved Domains (2) summary
      cd01337
      Location:22 → 331
      MDH_glyoxysomal_mitochondrial; Glyoxysomal and mitochondrial malate dehydrogenases
      PLN00106
      Location:10 → 326
      PLN00106; malate dehydrogenase
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