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    RGTB1 RAB geranylgeranyl transferase beta subunit 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831094, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RGTB1
    Official Full Name
    RAB geranylgeranyl transferase beta subunit 1
    Primary source
    TAIR:AT5G12210
    Locus tag
    AT5G12210
    See related
    Araport:AT5G12210
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtRGTB1; MXC9.17; MXC9_17; RAB geranylgeranyl transferase beta subunit 1
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    Genomic context

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    See RGTB1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (3947022..3949866)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene pyrimidine 2 Neighboring gene las1-like family protein Neighboring gene mediator of RNA polymerase II transcription subunit 19a-like protein Neighboring gene CLAVATA3/ESR-RELATED 22

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Rab Geranylgeranyl Transferase Beta Subunit Is Essential for Embryo and Seed Development in Arabidopsis thaliana. Rojek J, et al. Int J Mol Sci, 2021 Jul 24. PMID 34360673, Free PMC Article
    2. Rab-dependent vesicular traffic affects female gametophyte development in Arabidopsis. Rojek J, et al. J Exp Bot, 2021 Feb 2. PMID 32939545, Free PMC Article
    3. Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects. Hála M, et al. Plant J, 2010 May 1. PMID 20180921
    4. Rab geranylgeranyl transferase β subunit is essential for male fertility and tip growth in Arabidopsis. Gutkowska M, et al. J Exp Bot, 2015 Jan. PMID 25316062, Free PMC Article
    5. Arabidopsis Rab Geranylgeranyltransferases Demonstrate Redundancy and Broad Substrate Specificity in Vitro. Shi W, et al. J Biol Chem, 2016 Jan 15. PMID 26589801, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Rab Geranylgeranyl Transferase Beta Subunit Is Essential for Embryo and Seed Development in Arabidopsis thaliana.
      Title: The Rab Geranylgeranyl Transferase Beta Subunit Is Essential for Embryo and Seed Development in Arabidopsis thaliana.
    2. Data suggest that the Rab geranylgeranyltransferase heterodimer RGTA1/RGTB1 catalyzes prenylation of C-terminal cysteine residues in Rab GTPases in the presence of Rab escort protein (REP).
      Title: Arabidopsis Rab Geranylgeranyltransferases Demonstrate Redundancy and Broad Substrate Specificity in Vitro.
    3. Mutations in each of the RGTB genes cause a tip growth defect, visible as root hair and pollen tube deformations. The double mutant, with both AtRGTB genes disrupted, is non-viable due to absolute male sterility.
      Title: Rab geranylgeranyl transferase β subunit is essential for male fertility and tip growth in Arabidopsis.
    4. Disruption of Arabidopsis RAB geranylgeranyl transferase beta subunit RGTB1 results in pleiotropic growth and gravitropic defects in the shoot. [RGTB1]
      Title: Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_121259.4
    NM_203041.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables Rab geranylgeranyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables Rab geranylgeranyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within auxin export across the plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo sac development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within endosperm development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular auxin homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen-stigma interaction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein geranylgeranylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed coat development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Rab-protein geranylgeranyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RAB geranylgeranyl transferase beta subunit 1
    NP_568259.1
    • RAB geranylgeranyl transferase beta subunit 1 (RGTB1); FUNCTIONS IN: catalytic activity; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: RAB geranylgeranyl transferase beta subunit 2 (TAIR:AT3G12070.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_974770.1
    • RAB geranylgeranyl transferase beta subunit 1; FUNCTIONS IN: catalytic activity; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Terpenoid cylases/protein prenyltransferase alpha-alpha toroid (InterPro:IPR008930), Prenyltransferase/squalene oxidase (InterPro:IPR001330); BEST Arabidopsis thaliana protein match is: RAB geranylgeranyl transferase beta subunit 2 (TAIR:AT3G12070.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      3947022..3949866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121259.4 → NP_568259.1  RAB geranylgeranyl transferase beta subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568259.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84J75, Q9FMP2
      UniProtKB/TrEMBL
      A0A178UCS2, A0A5S9Y5Q6
      Conserved Domains (1) summary
      PLN03201
      Location:5 → 320
      PLN03201; RAB geranylgeranyl transferase beta-subunit; Provisional

    2. NM_203041.2 → NP_974770.1  RAB geranylgeranyl transferase beta subunit 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974770.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UAX0, F4JZH8
      Conserved Domains (2) summary
      PLN03201
      Location:5 → 319
      PLN03201; RAB geranylgeranyl transferase beta-subunit; Provisional
      cd02894
      Location:12 → 294
      GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84J75.1

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