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    APG5 autophagy protein Apg5 family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831594, updated on 18-Sep-2024

    Summary

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    Official Symbol
    APG5
    Official Full Name
    autophagy protein Apg5 family
    Primary source
    TAIR:AT5G17290
    Locus tag
    AT5G17290
    See related
    Araport:AT5G17290
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATATG5; ATG5; AUTOPHAGY 5; MKP11.20; MKP11_20
    Summary
    Autophagy protein ATG5. Forms a conjugate with ATG12 with an essential role in plant nutrient recycling. Mutants missing ATG5 display early senescence and are hypersensitive to nitrogen or carbon starvation, accompanied by a more rapid loss of organellar and cytoplasmic proteins.
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    Genomic context

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    See APG5 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (5686135..5689947, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein prenylyltransferase superfamily protein Neighboring gene oxidoreductase-like protein, amino-terminal protein Neighboring gene Homeodomain-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene UDP-glucose pyrophosphorylase 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interactome of Arabidopsis ATG5 Suggests Functions beyond Autophagy. Elander PH, et al. Int J Mol Sci, 2023 Aug 1. PMID 37569688, Free PMC Article
    2. Proteomic and lipidomic analyses of the Arabidopsis atg5 autophagy mutant reveal major changes in endoplasmic reticulum and peroxisome metabolisms and in lipid composition. Havé M, et al. New Phytol, 2019 Aug. PMID 31077612
    3. ATG5 defines a phagophore domain connected to the endoplasmic reticulum during autophagosome formation in plants. Le Bars R, et al. Nat Commun, 2014 Jun 20. PMID 24947672
    4. Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness. Minina EA, et al. J Exp Bot, 2018 Mar 14. PMID 29365132, Free PMC Article
    5. Autophagy negatively regulates cell death by controlling NPR1-dependent salicylic acid signaling during senescence and the innate immune response in Arabidopsis. Yoshimoto K, et al. Plant Cell, 2009 Sep. PMID 19773385, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interactome of Arabidopsis ATG5 Suggests Functions beyond Autophagy.
      Title: Interactome of Arabidopsis ATG5 Suggests Functions beyond Autophagy.
    2. After screening mutagenized lon2-2 seedlings for restored indole-3-butyric acid responsiveness, stabilization and processing of peroxisomal proteins, levels of several ATG proteins, and levels of the selective autophagy receptor NBR1/At4g24690, which accumulates when autophagy is impaired, were evaluated. The study recovered 21 alleles disrupting 6 ATG genes: ATG2, ATG3, ATG5, ATG7, ATG16, and ATG18a.
      Title: A facile forward-genetic screen for Arabidopsis autophagy mutants reveals twenty-one loss-of-function mutations disrupting six ATG genes.
    3. plants carrying the atg5 mutation presented all the characteristics of endoplasmic reticulum (ER) stress.
      Title: Proteomic and lipidomic analyses of the Arabidopsis atg5 autophagy mutant reveal major changes in endoplasmic reticulum and peroxisome metabolisms and in lipid composition.
    4. Overexpression of ATG5 or ATG7 stimulates Atg8 lipidation, autophagosome formation, and autophagic flux. It also induces transcriptional changes opposite to those observed in atg5 and atg7 mutants, favoring stress resistance and growth.
      Title: Transcriptional stimulation of rate-limiting components of the autophagic pathway improves plant fitness.
    5. ATG5 defines a phagophore domain connected to the endoplasmic reticulum during autophagosome formation in plants.
      Title: ATG5 defines a phagophore domain connected to the endoplasmic reticulum during autophagosome formation in plants.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_121735.5

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    acts_upstream_of_or_within autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    autophagy protein Apg5 family
    NP_197231.1
    • AUTOPHAGY 5 (APG5); FUNCTIONS IN: transporter activity; INVOLVED IN: autophagy, leaf senescence, response to starvation; LOCATED IN: cytoplasm; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Autophagy-related protein 5 (InterPro:IPR007239); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5686135..5689947 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121735.5 → NP_197231.1  autophagy protein Apg5 family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197231.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FFI2
      UniProtKB/TrEMBL
      A0A7G2FEJ8
      Conserved Domains (1) summary
      pfam04106
      Location:77 → 331
      APG5; Autophagy protein Apg5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FFI2.1

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