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    DAR4 DA1-related protein 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831657, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DAR4
    Official Full Name
    DA1-related protein 4
    Primary source
    TAIR:AT5G17890
    Locus tag
    AT5G17890
    See related
    Araport:AT5G17890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CHILLING SENSITIVE 3; CHS3; DA1-related protein 4; MPI7.6; MPI7_6
    Summary
    Encodes a protein that appears to be involved in defense responses. Contains TIR, NB-LRR and LIM domains. A gain of function allele exhibits cold dependent phenotypes including apparent activation of defense responses and an increased freezing tolerance.
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    Genomic context

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    See DAR4 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    13
    Sequence:
    Chromosome: 5; NC_003076.8 (5916862..5923494)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene disease resistance protein (TIR-NBS-LRR class) Neighboring gene ncRNA Neighboring gene microfibrillar-associated protein-like protein Neighboring gene cardiomyopathy-associated protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A mutant CHS3 protein with TIR-NB-LRR-LIM domains modulates growth, cell death and freezing tolerance in a temperature-dependent manner in Arabidopsis. Yang H, et al. Plant J, 2010 Jul. PMID 20444230
    2. Dual function of the CHS3-CSA1 immune receptor pair. He Y, et al. Trends Plant Sci, 2023 Apr. PMID 36804916
    3. IBR5 Modulates Temperature-Dependent, R Protein CHS3-Mediated Defense Responses in Arabidopsis. Liu J, et al. PLoS Genet, 2015 Oct. PMID 26451844, Free PMC Article
    4. The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis. Gu B, et al. Cell Host Microbe, 2023 Jun 14. PMID 37167970
    5. Identification and dynamics of Arabidopsis adaptor protein-2 complex and its involvement in floral organ development. Yamaoka S, et al. Plant Cell, 2013 Aug. PMID 23975897, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis.
      Title: The integrated LIM-peptidase domain of the CSA1-CHS3/DAR4 paired immune receptor detects changes in DA1 peptidase inhibitors in Arabidopsis.
    2. Dual function of the CHS3-CSA1 immune receptor pair.
      Title: Dual function of the CHS3-CSA1 immune receptor pair.
    3. IBR5 encodes a putative dual-specificity protein phosphatase. The accumulation of CHS3 protein at chilling temperatures is inhibited by the IBR5 mutation.
      Title: IBR5 Modulates Temperature-Dependent, R Protein CHS3-Mediated Defense Responses in Arabidopsis.
    4. The chs3-1 mutation enhanced freezing tolerance, which was correlated with growth defect and cell death phenotypes caused by activated defense responses.
      Title: A mutant CHS3 protein with TIR-NB-LRR-LIM domains modulates growth, cell death and freezing tolerance in a temperature-dependent manner in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_121795.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DA1-related protein 4
    NP_197291.2
    • DA1-related protein 4 (DAR4); FUNCTIONS IN: zinc ion binding, ATP binding; INVOLVED IN: response to cold, defense response; LOCATED IN: cellular_component unknown; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, LIM-type (InterPro:IPR001781), NB-ARC (InterPro:IPR002182), Disease resistance protein (InterPro:IPR000767), Protein of unknown function DUF3633 (InterPro:IPR022087); BEST Arabidopsis thaliana protein match is: disease resistance protein (TIR-NBS-LRR class), putative (TAIR:AT4G36140.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5916862..5923494
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121795.4 → NP_197291.2  DA1-related protein 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197291.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FKN7, Q9FKN8
      UniProtKB/TrEMBL
      A0A654G231
      Conserved Domains (7) summary
      cd00009
      Location:166 → 294
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      cd09396
      Location:1240 → 1291
      LIM_DA1; The Lim domain of DA1
      PLN03210
      Location:26 → 844
      PLN03210; Resistant to P. syringae 6; Provisional
      sd00033
      Location:618 → 640
      LRR_RI; leucine-rich repeat [structural motif]
      pfam01582
      Location:30 → 163
      TIR; TIR domain
      pfam07725
      Location:594 → 613
      LRR_3; Leucine Rich Repeat
      pfam12315
      Location:1387 → 1602
      DUF3633; Protein of unknown function (DUF3633)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FKN7.2

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