BIN4 double-stranded DNA binding protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BIN4
Official Full Name: double-stranded DNA binding protein
Primary source: TAIR:AT5G24630
Locus tag: AT5G24630
See related: Araport:AT5G24630
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: brassinosteroid-insensitive4; K18P6.17; K18P6_17; MID; MIDGET
Summary: This gene is predicted to encode a protein that forms part of the topoisomerase VI complex. BIN4 is a nuclear-localized protein that can bind DNA. bin4 mutants are brassinolide-insensitive dwarves with severely reduced cell size in leaves, roots, and hypocotyls. Proper development of root hairs and trichomes is also disrupted in bin4 mutants and they have elevated levels of double strand breaks in their cotyledon cells.
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Genomic context

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See BIN4 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 14

Sequence:: Chromosome: 5; NC_003076.8 (8432384..8436193, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The MID protein plays a role in COP1/SPA1-controlled repression of flowering under short-day conditions. [MIDGET] [MID]
Title: MIDGET cooperates with COP1 and SPA1 to repress flowering in Arabidopsis thaliana.
An Arabidopsis thaliana mutant, brassinosteroid-insensitive4 (bin4), in which the growth of various organs is dramatically reduced, is dexcribed.
Title: BIN4, a novel component of the plant DNA topoisomerase VI complex, is required for endoreduplication in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001161263.1

Supported by ESTs:

NM_001161264.1

Supported by ESTs:

NM_001161265.1

Supported by ESTs:

NM_001161266.1

Supported by ESTs:

NM_001161267.1

Supported by ESTs:

NM_001343885.1

Supported by ESTs:

NM_001343886.1

Supported by ESTs:

NM_001343887.1

Supported by ESTs:

NM_001343888.1

Supported by ESTs:

NM_001343889.1

Supported by ESTs:

NM_001343890.1

Supported by ESTs:

NM_122371.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA endoreduplication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA endoreduplication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant epidermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within shoot system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trichome morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	IEA Inferred from Electronic Annotation more info
part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: double-stranded DNA binding protein

NP_001154735.1

brassinosteroid-insensitive4 (BIN4); FUNCTIONS IN: double-stranded DNA binding; INVOLVED IN: in 7 processes; LOCATED IN: DNA topoisomerase complex (ATP-hydrolyzing), nucleus; EXPRESSED IN: cotyledon vascular system, cotyledon, root tip, leaf trichome, leaf; Has 594 Blast hits to 509 proteins in 128 species: Archae - 0; Bacteria - 28; Metazoa - 188; Fungi - 140; Plants - 83; Viruses - 1; Other Eukaryotes - 154 (source: NCBI BLink).

NP_001154736.1

brassinosteroid-insensitive4 (BIN4); FUNCTIONS IN: double-stranded DNA binding; INVOLVED IN: in 7 processes; LOCATED IN: DNA topoisomerase complex (ATP-hydrolyzing), nucleus; EXPRESSED IN: cotyledon vascular system, cotyledon, root tip, leaf trichome, leaf; Has 3010 Blast hits to 2259 proteins in 308 species: Archae - 6; Bacteria - 594; Metazoa - 1079; Fungi - 389; Plants - 150; Viruses - 13; Other Eukaryotes - 779 (source: NCBI BLink).

NP_001154737.1

brassinosteroid-insensitive4 (BIN4); FUNCTIONS IN: double-stranded DNA binding; INVOLVED IN: in 7 processes; LOCATED IN: DNA topoisomerase complex (ATP-hydrolyzing), nucleus; EXPRESSED IN: cotyledon vascular system, cotyledon, root tip, leaf trichome, leaf; Has 3010 Blast hits to 2259 proteins in 308 species: Archae - 6; Bacteria - 594; Metazoa - 1079; Fungi - 389; Plants - 150; Viruses - 13; Other Eukaryotes - 779 (source: NCBI BLink).

NP_001154738.1

brassinosteroid-insensitive4 (BIN4); FUNCTIONS IN: double-stranded DNA binding; INVOLVED IN: in 7 processes; LOCATED IN: DNA topoisomerase complex (ATP-hydrolyzing), nucleus; EXPRESSED IN: cotyledon vascular system, cotyledon, root tip, leaf trichome, leaf; Has 2167 Blast hits to 1734 proteins in 263 species: Archae - 6; Bacteria - 177; Metazoa - 877; Fungi - 312; Plants - 129; Viruses - 12; Other Eukaryotes - 654 (source: NCBI BLink).

NP_001154739.1

brassinosteroid-insensitive4 (BIN4); FUNCTIONS IN: double-stranded DNA binding; INVOLVED IN: in 7 processes; LOCATED IN: DNA topoisomerase complex (ATP-hydrolyzing), nucleus; EXPRESSED IN: cotyledon vascular system, cotyledon, root tip, leaf trichome, leaf; Has 3628 Blast hits to 2405 proteins in 320 species: Archae - 6; Bacteria - 1196; Metazoa - 1107; Fungi - 390; Plants - 165; Viruses - 17; Other Eukaryotes - 747 (source: NCBI BLink).

NP_197851.5

brassinosteroid-insensitive4 (BIN4); FUNCTIONS IN: double-stranded DNA binding; INVOLVED IN: in 7 processes; LOCATED IN: DNA topoisomerase complex (ATP-hydrolyzing), nucleus; EXPRESSED IN: 6 plant structures; Has 2751 Blast hits to 2146 proteins in 312 species: Archae - 6; Bacteria - 241; Metazoa - 1096; Fungi - 396; Plants - 170; Viruses - 20; Other Eukaryotes - 822 (source: NCBI BLink).