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    CYP707A3 cytochrome P450, family 707, subfamily A, polypeptide 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 834570, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CYP707A3
    Official Full Name
    cytochrome P450, family 707, subfamily A, polypeptide 3
    Primary source
    TAIR:AT5G45340
    Locus tag
    AT5G45340
    See related
    Araport:AT5G45340
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ''cytochrome P450; cytochrome P450; family 707; K9E15.12; K9E15_12; polypeptide 3; polypeptide 3''; subfamily A
    Summary
    Encodes a protein with ABA 8'-hydroxylase activity; involved in ABA catabolism. Mutant analyses show that disruption in the gene results in more drought tolerance whereas overexpression results in increased transpiration rate and reduced drought tolerance. Gene involved in postgermination growth. Plant P450 CYP707A3, ABA 8'-hydroxylase, binds enantioselectively (+)-ABA but not (-)-ABA, whereas the enzyme binds both enantiomers of AHI1 (a structural ABA analogue used as ABA 8'-hydroxylase competitive inhibitor).
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    Genomic context

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    See CYP707A3 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (18368532..18371021, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene late embryogenesis abundant protein Neighboring gene decapping 5-like protein Neighboring gene proline-rich family protein Neighboring gene F-box family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana. Umezawa T, et al. Plant J, 2006 Apr. PMID 16623881
    2. High humidity induces abscisic acid 8'-hydroxylase in stomata and vasculature to regulate local and systemic abscisic acid responses in Arabidopsis. Okamoto M, et al. Plant Physiol, 2009 Feb. PMID 19036833, Free PMC Article
    3. Hypoxia reshapes Arabidopsis root architecture by integrating ERF-VII factor response and abscisic acid homoeostasis. Eysholdt-Derzsó E, et al. Plant Cell Environ, 2024 Aug. PMID 38616485
    4. Arabidopsis CYP707As encode (+)-abscisic acid 8'-hydroxylase, a key enzyme in the oxidative catabolism of abscisic acid. Saito S, et al. Plant Physiol, 2004 Apr. PMID 15064374, Free PMC Article
    5. Regulation of hormone metabolism in Arabidopsis seeds: phytochrome regulation of abscisic acid metabolism and abscisic acid regulation of gibberellin metabolism. Seo M, et al. Plant J, 2006 Nov. PMID 17010113

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CYP707A3 reduces the amount of mobile abscisic acid in vacular tissues in response to high humidity in Arabidopsis.
      Title: High humidity induces abscisic acid 8'-hydroxylase in stomata and vasculature to regulate local and systemic abscisic acid responses in Arabidopsis.
    2. Determins threshold levels of abscisic acid during dehydration and after rehydration.
      Title: CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    NM_123902.3
    NM_180805.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables (+)-abscisic acid 8'-hydroxylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to red or far red light IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450, family 707, subfamily A, polypeptide 3
    NP_199347.2
    • ''cytochrome P450, family 707, subfamily A, polypeptide 3'' (CYP707A3); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 8 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 1 (TAIR:AT4G19230.2); Has 36434 Blast hits to 36316 proteins in 1856 species: Archae - 82; Bacteria - 8479; Metazoa - 11318; Fungi - 6149; Plants - 8238; Viruses - 6; Other Eukaryotes - 2162 (source: NCBI BLink).
    NP_851136.1
    • ''cytochrome P450, family 707, subfamily A, polypeptide 3'' (CYP707A3); FUNCTIONS IN: oxygen binding, (+)-abscisic acid 8'-hydroxylase activity; INVOLVED IN: in 8 processes; LOCATED IN: endomembrane system; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, E-class, group I (InterPro:IPR002401), Cytochrome P450, conserved site (InterPro:IPR017972); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 707, subfamily A, polypeptide 1 (TAIR:AT4G19230.1); Has 36672 Blast hits to 36553 proteins in 1858 species: Archae - 82; Bacteria - 8489; Metazoa - 11350; Fungi - 6268; Plants - 8323; Viruses - 6; Other Eukaryotes - 2154 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      18368532..18371021 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180805.4 → NP_851136.1  cytochrome P450, family 707, subfamily A, polypeptide 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851136.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3E8G7, Q9FH76
      UniProtKB/TrEMBL
      A0A178UJX7, A0A5S9YCB8
      Conserved Domains (1) summary
      PLN02196
      Location:1 → 463
      PLN02196; abscisic acid 8'-hydroxylase

    2. NM_123902.3 → NP_199347.2  cytochrome P450, family 707, subfamily A, polypeptide 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_199347.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UJX7, A0A5S9YCB8
      Conserved Domains (1) summary
      PLN02196
      Location:1 → 446
      PLN02196; abscisic acid 8'-hydroxylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FH76.1

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