BIR1 BAK1-interacting receptor-like kinase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BIR1
Official Full Name: BAK1-interacting receptor-like kinase 1
Primary source: TAIR:AT5G48380
Locus tag: AT5G48380
See related: Araport:AT5G48380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BAK1-interacting receptor-like kinase 1; K23F3.10
Summary: Encodes a BAK1-interacting receptor-like kinase named BIR1. Negatively regulates multiple plant resistance signaling pathways, one of which is the SOBIR1(AT2G31880)-dependent pathway.
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Genomic context

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See BIR1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 3

Sequence:: Chromosome: 5; NC_003076.8 (19604089..19607147, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This work provides novel mechanistic insights into the regulation of BIR1 homeostasis that may be common for other plant immune components.
Title: The immune repressor BIR1 contributes to antiviral defense and undergoes transcriptional and post-transcriptional regulation during viral infections.
BIR1 has likely evolved to keep BAK1-mediated cell death signaling under tight control, thus preventing undesired autoimmunity.
Title: Structural basis for BIR1-mediated negative regulation of plant immunity.
BAK1 and SOBIR1 associate with each other in planta when the function of BIR1 is compromised.
Title: Loss-of-function of Arabidopsis receptor-like kinase BIR1 activates cell death and defense responses mediated by BAK1 and SOBIR1.
negative regulator of plant immunity
Title: Regulation of SOBIR1 accumulation and activation of defense responses in bir1-1 by specific components of ER quality control.
BON1 and BIR1 might modulate both PAMP- and R protein-triggered immune responses.
Title: BON1 interacts with the protein kinases BIR1 and BAK1 in modulation of temperature-dependent plant growth and cell death in Arabidopsis.
Data suggests that BIR1 negatively regulates multiple plant resistance signaling pathways, one of which is the SOBIR1-dependent pathway identified here. [BIR1]
Title: Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_124213.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables receptor serine/threonine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of defense response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plant-type hypersensitive response	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	ISM Inferred from Sequence Model more info
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	HDA more info	PubMed

General protein information

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Preferred Names: BAK1-interacting receptor-like kinase 1

NP_568696.1

BAK1-interacting receptor-like kinase 1 (BIR1); FUNCTIONS IN: protein kinase activity; INVOLVED IN: negative regulation of defense response; LOCATED IN: plasma membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT3G28450.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

19604089..19607147 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_124213.5 → NP_568696.1 BAK1-interacting receptor-like kinase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568696.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8H771, Q8W4H2, Q9ASS4, Q9LV74

UniProtKB/TrEMBL

A0A5S9YC70, A0A654G940

Conserved Domains (3) summary

PLN00113
Location:32 → 192

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

cd14066
Location:309 → 586

STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs

sd00033
Location:102 → 126

LRR_RI; leucine-rich repeat [structural motif]