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    FHIT FRAGILE HISTIDINE TRIAD [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835936, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FHIT
    Official Full Name
    FRAGILE HISTIDINE TRIAD
    Primary source
    TAIR:AT5G58240
    Locus tag
    AT5G58240
    See related
    Araport:AT5G58240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FRAGILE HISTIDINE TRIAD; MCK7.11; MCK7_11
    Summary
    Encodes a Fhit protein. Has nucleoside phosphoramidase and adenylylsulfatase activities.
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    Genomic context

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    See FHIT in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (23558114..23559353, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene evolutionarily conserved C-terminal region 10 Neighboring gene Calcineurin-like metallo-phosphoesterase superfamily protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene transthyretin-like protein Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene YCF54 Neighboring gene oxidoreductases, acting on NADH or NADPH, quinone or similar compound as acceptor Neighboring gene ABC transporter of the mitochondrion 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis Fhit-like tumor suppressor resumes early terminated constitutive triple response1-10 mRNA translation. Zhang R, et al. Plant Physiol, 2024 Jun 28. PMID 38563472
    2. Adenylylsulfate-ammonia adenylyltransferase activity is another inherent property of Fhit proteins. Wojdyła-Mamoń AM, et al. Biosci Rep, 2015 Jun 25. PMID 26181368, Free PMC Article
    3. Fhit proteins can also recognize substrates other than dinucleoside polyphosphates. Guranowski A, et al. FEBS Lett, 2008 Sep 3. PMID 18694747
    4. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Adenylylsulfate-ammonia adenylyltransferase activity is another inherent property of Fhit proteins.
      Title: Adenylylsulfate-ammonia adenylyltransferase activity is another inherent property of Fhit proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001345293.1
    NM_125209.3
    NM_203228.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenosine 5'-monophosphoramidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylylsulfatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables adenylylsulfate-ammonia adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables bis(5'-adenosyl)-triphosphatase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in translation reinitiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    FRAGILE HISTIDINE TRIAD
    NP_200632.2
    • FRAGILE HISTIDINE TRIAD (FHIT); CONTAINS InterPro DOMAIN/s: Histidine triad-like motif (InterPro:IPR011146), Histidine triad, conserved site (InterPro:IPR019808), Histidine triad (HIT) protein (InterPro:IPR001310), Histidine triad motif (InterPro:IPR011151); Has 5210 Blast hits to 5210 proteins in 1676 species: Archae - 233; Bacteria - 3245; Metazoa - 250; Fungi - 213; Plants - 74; Viruses - 2; Other Eukaryotes - 1193 (source: NCBI BLink).
    NP_974957.1
    • FRAGILE HISTIDINE TRIAD (FHIT); CONTAINS InterPro DOMAIN/s: Histidine triad-like motif (InterPro:IPR011146), Histidine triad, conserved site (InterPro:IPR019808), Histidine triad (HIT) protein (InterPro:IPR001310), Histidine triad motif (InterPro:IPR011151); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23558114..23559353 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125209.3 → NP_200632.2  FRAGILE HISTIDINE TRIAD [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200632.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KEV7, Q84WL2, Q9LVM4
      UniProtKB/TrEMBL
      A0A178UKE7, A0A5S9YFS9
      Conserved Domains (1) summary
      cd01275
      Location:30 → 148
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

    2. NM_203228.2 → NP_974957.1  FRAGILE HISTIDINE TRIAD [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4KEV7
      Conserved Domains (1) summary
      cd01275
      Location:10 → 128
      FHIT; FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into ...

    3. NM_001345293.1 → NP_001331086.1  FRAGILE HISTIDINE TRIAD [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8BCS8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4KEV7.1

    Gene LinkOut

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