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    FOLK Phosphatidate cytidylyltransferase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835969, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FOLK
    Official Full Name
    Phosphatidate cytidylyltransferase family protein
    Primary source
    TAIR:AT5G58560
    Locus tag
    AT5G58560
    See related
    Araport:AT5G58560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    farnesol kinase; MZN1.8; MZN1_8
    Summary
    FOLK is a farnesol kinase that can phosphorylate farnesol using an NTP donor. It can also phosphorylate geraniol, or geranylgeraniol, but it prefers farnesol in experiments performed using yeast membranes. folk loss-of-function mutants show ABA hypersensitivity in a seed germination assay and the mutants also exhibit abnormal flower development, including extra carpel formation, when subjected to water stress.
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    Genomic context

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    See FOLK in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (23670267..23672877)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein kinase superfamily protein Neighboring gene ETO1-like 2 Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene SAGA-associated factor-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis. Fitzpatrick AH, et al. Plant J, 2011 Jun. PMID 21395888
    2. Tocopherol and phylloquinone biosynthesis in chloroplasts requires the phytol kinase VITAMIN E PATHWAY GENE5 (VTE5) and the farnesol kinase (FOLK). Romer J, et al. Plant Cell, 2024 Mar 29. PMID 38124486,
    3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Arabidopsis FOLK gene encodes a farnesol kinase capable of transferring the gamma-phosphate of ATP to farnesol.
      Title: Farnesol kinase is involved in farnesol metabolism, ABA signaling and flower development in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_125242.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP:farnesol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP:geranylgeraniol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CTP:farnesol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CTP:geranylgeraniol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables geraniol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables geranylgeraniol kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carpel development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within farnesol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within isoprenoid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vitamin E biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Phosphatidate cytidylyltransferase family protein
    NP_200664.1
    • Phosphatidate cytidylyltransferase family protein; FUNCTIONS IN: phosphatidate cytidylyltransferase activity, transferase activity, transferring phosphorus-containing groups; INVOLVED IN: phospholipid biosynthetic process; LOCATED IN: membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Phosphatidate cytidylyltransferase (InterPro:IPR000374); BEST Arabidopsis thaliana protein match is: vitamin E pathway gene 5 (TAIR:AT5G04490.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      23670267..23672877
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125242.4 → NP_200664.1  Phosphatidate cytidylyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200664.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q67ZA1, Q67ZM7, Q8LAW9, Q9LV00
      UniProtKB/TrEMBL
      A0A178U7L6, A0A5S9YF87, A0A654GC86
      Conserved Domains (1) summary
      cl21502
      Location:94 → 306
      CTP_transf_1; Cytidylyltransferase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q67ZM7.2

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