PLC1 phospholipase C1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PLC1
Official Full Name: phospholipase C1
Primary source: TAIR:AT5G58670
Locus tag: AT5G58670
See related: Araport:AT5G58670
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA PHOSPHOLIPASE C; ATPLC; ATPLC1; MZN1.12; MZN1_12; PHOSPHOLIPASE C; phospholipase C 1; phospholipase C1
Summary: phosphatidylinositol-specific phospholipase C is induced to a significant extent under various environmental stresses, such as dehydration, salinity, and low temperature. May play a role in secondary ABA response. There are two genes called ATPLC1, one corresponding to AT4g38530 and one corresponding ot AT5g58670 (this one).
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Genomic context

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See PLC1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 8

Sequence:: Chromosome: 5; NC_003076.8 (23704231..23707003, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic interaction between TTG2 and AtPLC1 reveals a role for phosphoinositide signaling in a co-regulated suite of Arabidopsis epidermal pathways.
Title: Genetic interaction between TTG2 and AtPLC1 reveals a role for phosphoinositide signaling in a co-regulated suite of Arabidopsis epidermal pathways.
The activity of non-specific phospholipase C is affected by Aluminum-induced changes in plasma membrane physical properties.
Title: Aluminum ions alter the function of non-specific phospholipase C through the changes in plasma membrane physical properties.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_125254.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
enables phospholipase C activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase C activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cold	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: phospholipase C1

NP_568881.1

phospholipase C1 (PLC1); CONTAINS InterPro DOMAIN/s: Phospholipase C, phosphoinositol-specific, EF-hand-like (InterPro:IPR015359), Phospholipase C, phosphatidylinositol-specific, X domain (InterPro:IPR000909), EF-Hand 1, calcium-binding site (InterPro:IPR018247), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase C, phosphoinositol-specific (InterPro:IPR001192), Phospholipase C, phosphatidylinositol-specific, Y domain (InterPro:IPR001711), PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (InterPro:IPR017946), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: phospholipase C1 (TAIR:AT4G38530.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

23704231..23707003 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125254.2 → NP_568881.1 phospholipase C1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_568881.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O49970, Q39032

UniProtKB/TrEMBL

A0A178UL38, A0A5S9YGD2

Conserved Domains (4) summary

cd00275
Location:429 → 556

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

PLN02228
Location:1 → 561

PLN02228; Phosphoinositide phospholipase C

pfam09279
Location:25 → 102

EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

cl14615
Location:105 → 397

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily