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    PXY Leucine-rich repeat protein kinase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836269, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PXY
    Official Full Name
    Leucine-rich repeat protein kinase family protein
    Primary source
    TAIR:AT5G61480
    Locus tag
    AT5G61480
    See related
    Araport:AT5G61480
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MCI2.4; MCI2_4; PHLOEM INTERCALATED WITH XYLEM; TDIF receptor; TDR
    Summary
    Encodes PXY, a receptor-like kinase essential for maintaining polarity during plant vascular-tissue development.
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    Genomic context

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    See PXY in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (24724337..24728244, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene C2H2-like zinc finger protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide. Morita J, et al. Nat Commun, 2016 Aug 8. PMID 27498761, Free PMC Article
    2. Differential CLE peptide perception by plant receptors implicated from structural and functional analyses of TDIF-TDR interactions. Li Z, et al. PLoS One, 2017. PMID 28384649, Free PMC Article
    3. Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs. Zhang H, et al. Cell Res, 2016 May. PMID 27055373, Free PMC Article
    4. Wood Formation in Trees Is Increased by Manipulating PXY-Regulated Cell Division. Etchells JP, et al. Curr Biol, 2015 Apr 20. PMID 25866390, Free PMC Article
    5. TDIF peptide signaling regulates vascular stem cell proliferation via the WOX4 homeobox gene in Arabidopsis. Hirakawa Y, et al. Plant Cell, 2010 Aug. PMID 20729381, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis.
      Title: A PXY-Mediated Transcriptional Network Integrates Signaling Mechanisms to Control Vascular Development in Arabidopsis.
    2. Loss of function by T-DNA insertion in C-terminally encoded peptide receptor 2 (CEPR2) together with phloem intercalated with xylem (PXY) and PXY-Like 2 (PXL2) led to abscisic acid (ABA) hypersensitivity, while CEPR2 overexpression led to ABA insensitivity compared with the wild type, indicating the redundant and negative roles of CEPR2, PXY, and PXL2 in ABA signaling.
      Title: CEPR2 phosphorylates and accelerates the degradation of PYR/PYLs in Arabidopsis.
    3. a conserved TDIF-recognition mechanism of TDR among plant species, is reported.
      Title: Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide.
    4. the crystal structure of TDIF in complex with its receptor PXY, a leucine-rich repeat receptor kinase (LRR-RK), is reported.
      Title: Crystal structure of PXY-TDIF complex reveals a conserved recognition mechanism among CLE peptide-receptor pairs.
    5. structures provide insights about the ligand perception and specific interactions between the CLE peptides and their cognate receptors
      Title: Differential CLE peptide perception by plant receptors implicated from structural and functional analyses of TDIF-TDR interactions.
    6. Data demonstrate that the PXY-CLE pathway has evolved to regulate secondary growth and manipulating this pathway can result in dramatically increased tree growth and productivity.
      Title: Wood Formation in Trees Is Increased by Manipulating PXY-Regulated Cell Division.
    7. This study delineates a TDIF-TDR-BIN2 signalling cascade that controls regulation of ARF and AUX/IAA interaction independent of auxin perception during lateral root development. [TDR]
      Title: A secreted peptide acts on BIN2-mediated phosphorylation of ARFs to potentiate auxin response during lateral root development.
    8. PXY and receptor kinase ERECTA (ER) affect the organisation of the vascular tissue but not the rate of cell division
      Title: WOX4 and WOX14 act downstream of the PXY receptor kinase to regulate plant vascular proliferation independently of any role in vascular organisation.
    9. We propose a model whereby vascular cell division is regulated both by PXY signalling and ethylene/ERF signalling
      Title: Plant vascular cell division is maintained by an interaction between PXY and ethylene signalling.
    10. Auxin-dependent stimulation of cambium activity depends on WOX4 and its upstream regulator PXY.
      Title: WOX4 imparts auxin responsiveness to cambium cells in Arabidopsis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_125541.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell division IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem or xylem histogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in procambium histogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within secondary shoot formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xylem development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Leucine-rich repeat protein kinase family protein
    NP_200956.1
    • PHLOEM INTERCALATED WITH XYLEM (PXY); FUNCTIONS IN: protein serine/threonine kinase activity, protein kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat transmembrane protein kinase family protein (TAIR:AT4G28650.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24724337..24728244 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125541.2 → NP_200956.1  Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FII5
      UniProtKB/TrEMBL
      A0A178U8Y0, A0A5S9YH83, A0A654GD75
      Conserved Domains (3) summary
      PLN00113
      Location:61 → 1000
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00031
      Location:491 → 513
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:227 → 250
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FII5.1

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