ACS5 ACC synthase 5 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ACS5
Official Full Name: ACC synthase 5
Primary source: TAIR:AT5G65800
Locus tag: AT5G65800
See related: Araport:AT5G65800
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: 1-AMINO-1-CYCLOPROPANECARBOXYLATE SYNTHASE; ACC synthase 5; ATACS5; CIN5; CYTOKININ-INSENSITIVE 5; ETHYLENE OVERPRODUCER 2; ETO2; MPA24.15; MPA24_15
Summary: 1-aminocyclopropane-1-carboxylate synthase (ACS) is encoded by a multigene family consisting of at least five members whose expression is induced by hormones, developmental signals, and protein synthesis inhibition.
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Genomic context

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See ACS5 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 3

Sequence:: Chromosome: 5; NC_003076.8 (26330746..26332812, complement)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The transcription factor WRKY22 modulates ethylene biosynthesis and root development through transactivating the transcription of ACS5 and ACO5 in Arabidopsis.
Title: The transcription factor WRKY22 modulates ethylene biosynthesis and root development through transactivating the transcription of ACS5 and ACO5 in Arabidopsis.
Data indicate that light stabilizes ACC synthase 5 (ACS5) by inhibiting the degradation mechanism that acts through the C-terminus of ACS5.
Title: Light-induced stabilization of ACS contributes to hypocotyl elongation during the dark-to-light transition in Arabidopsis seedlings.
CK1.8 regulates ACS5 stability by phosphorylation.
Title: Casein kinase 1 regulates ethylene synthesis by phosphorylating and promoting the turnover of ACS5.
Treatment of etiolated Arabidopsis seedlings with light rapidly increases the stability of ACS5 protein and destabilizes the ETO1/EOLs proteins.
Title: ACC synthase and its cognate E3 ligase are inversely regulated by light.
ACS5 protein stability is regulated by the level of ETHYLENE-OVERPRODUCER1 (ETO1)/ETO1-LIKE (EOL) and 14-3-3 proteins.
Title: 14-3-3 regulates 1-aminocyclopropane-1-carboxylate synthase protein turnover in Arabidopsis.
Brassinosteroid acts post-transcriptionally by increasing the stability of ACS5 protein in a manner similar to cytokinin.
Title: Regulation of ACS protein stability by cytokinin and brassinosteroid.
A study evaluting ethylene-giberillic acid crosstalk in gibberellin-insensitive (gai), ethylene-overproducing 2-1 (eto2-1) double mutant A. thaliana is reported. [ETO2]
Title: Reduced gibberellin response affects ethylene biosynthesis and responsiveness in the Arabidopsis gai eto2-1 double mutant.
Expression in response to plant growth regulators and abiotic stress in roots and aerial parts as demonstrated by expression of the GUS reporter in A. thaliana. [ACS5]
Title: The GUS reporter-aided analysis of the promoter activities of Arabidopsis ACC synthase genes AtACS4, AtACS5, and AtACS7 induced by hormones and stresses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_125977.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 1-aminocyclopropane-1-carboxylate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-aminocyclopropane-1-carboxylate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within 1-aminocyclopropane-1-carboxylate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ethylene biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ethylene biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phloem or xylem histogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cytokinin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: ACC synthase 5

NP_201381.1

ACC synthase 5 (ACS5); CONTAINS InterPro DOMAIN/s: 1-aminocyclopropane-1-carboxylate synthase (InterPro:IPR001176), Pyridoxal phosphate-dependent transferase, major domain (InterPro:IPR015424), Aminotransferase, class I/classII (InterPro:IPR004839), Aminotransferases, class-I, pyridoxal-phosphate-binding site (InterPro:IPR004838), Pyridoxal phosphate-dependent transferase, major region, subdomain 1 (InterPro:IPR015421), Pyridoxal phosphate-dependent transferase, major region, subdomain 2 (InterPro:IPR015422); BEST Arabidopsis thaliana protein match is: 1-aminocyclopropane-1-carboxylate synthase 9 (TAIR:AT3G49700.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).