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    GLR2.1 glutamate receptor 2.1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 832768, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLR2.1
    Official Full Name
    glutamate receptor 2.1
    Primary source
    TAIR:AT5G27100
    Locus tag
    AT5G27100
    See related
    Araport:AT5G27100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA GLUTAMATE RECEPTOR 2.1; ATGLR2.1; glutamate receptor 2.1; T21B4.10; T21B4_10
    Summary
    member of Putative ligand-gated ion channel subunit family
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    Genomic context

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    See GLR2.1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    5
    Sequence:
    Chromosome: 5; NC_003076.8 (9535059..9538444, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene AGAMOUS-like 54 Neighboring gene ncRNA Neighboring gene miscRNA Neighboring gene uncharacterized protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene NOP56-like pre RNA processing ribonucleoprotein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inter-subunit interactions between glutamate-like receptors in Arabidopsis. Price MB, et al. Plant Signal Behav, 2013. PMID 24300102, Free PMC Article
    2. The identity of plant glutamate receptors. Lacombe B, et al. Science, 2001 May 25. PMID 11379626
    3. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_122592.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables intracellularly ligand-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in calcium-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to amino acid stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within intracellular calcium ion homeostasis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor 2.1
    NP_198062.2
    • glutamate receptor 2.1 (GLR2.1); FUNCTIONS IN: protein binding, intracellular ligand-gated ion channel activity; INVOLVED IN: cellular calcium ion homeostasis, response to light stimulus; LOCATED IN: endomembrane system, membrane; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis, 4 leaf senescence stage, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Extracellular solute-binding protein, family 3 (InterPro:IPR001638), Ionotropic glutamate receptor (InterPro:IPR001320), Extracellular ligand-binding receptor (InterPro:IPR001828), Glutamate receptor-related (InterPro:IPR015683), Ionotropic glutamate-like receptor, plant (InterPro:IPR017103); BEST Arabidopsis thaliana protein match is: glutamate receptor 2.2 (TAIR:AT2G24720.1); Has 5641 Blast hits to 5531 proteins in 742 species: Archae - 75; Bacteria - 1407; Metazoa - 3255; Fungi - 0; Plants - 653; Viruses - 0; Other Eukaryotes - 251 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      9535059..9538444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_122592.4 → NP_198062.2  glutamate receptor 2.1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_198062.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04660, Q0WSC5
      Conserved Domains (5) summary
      cd06366
      Location:49 → 411
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      cd13686
      Location:452 → 794
      GluR_Plant; Plant glutamate receptor domain; the type 2 periplasmic binding protein fold
      pfam00060
      Location:576 → 835
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:49 → 392
      ANF_receptor; Receptor family ligand binding region
      cl21456
      Location:478 → 685
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04660.2

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