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    CO B-box type zinc finger protein with CCT domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831441, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CO
    Official Full Name
    B-box type zinc finger protein with CCT domain-containing protein
    Primary source
    TAIR:AT5G15840
    Locus tag
    AT5G15840
    See related
    Araport:AT5G15840
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    B-box domain protein 1; BBX1; CONSTANS; F14F8.220; F14F8_220; FG
    Summary
    Encodes a protein showing similarities to zinc finger transcription factors, involved in regulation of flowering under long days. Acts upstream of FT and SOC1.
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    Genomic context

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    Location:
    chromosome: 5
    Exon count:
    1
    Sequence:
    Chromosome: 5; NC_003076.8 (5170162..5173085, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CONSTANS-like 1 Neighboring gene uncharacterized protein Neighboring gene prenylcysteine methylesterase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variation in Arabidopsis flowering time associated with cis-regulatory variation in CONSTANS. Rosas U, et al. Nat Commun, 2014 Apr 16. PMID 24736505, Free PMC Article
    2. Crystal structure of a tandem B-box domain from Arabidopsis CONSTANS. Dahal P, et al. Biochem Biophys Res Commun, 2022 Apr 9. PMID 35168062
    3. CONSTANS mediates between the circadian clock and the control of flowering in Arabidopsis. Suárez-López P, et al. Nature, 2001 Apr 26. PMID 11323677
    4. Graft transmission of a floral stimulant derived from CONSTANS. Ayre BG, et al. Plant Physiol, 2004 Aug. PMID 15299137, Free PMC Article
    5. Circadian Clock and Photoperiodic Flowering in Arabidopsis: CONSTANS Is a Hub for Signal Integration. Shim JS, et al. Plant Physiol, 2017 Jan. PMID 27688622, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Photoperiodic flowering in Arabidopsis: Multilayered regulatory mechanisms of CONSTANS and the florigen FLOWERING LOCUS T.
      Title: Photoperiodic flowering in Arabidopsis: Multilayered regulatory mechanisms of CONSTANS and the florigen FLOWERING LOCUS T.
    2. Crystal structure of a tandem B-box domain from Arabidopsis CONSTANS.
      Title: Crystal structure of a tandem B-box domain from Arabidopsis CONSTANS.
    3. Nucleoporin 160 Regulates Flowering through Anchoring HOS1 for Destabilizing CO in Arabidopsis.
      Title: Nucleoporin 160 Regulates Flowering through Anchoring HOS1 for Destabilizing CO in Arabidopsis.
    4. Structural insights into the multivalent binding of the Arabidopsis FLOWERING LOCUS T promoter by the CO-NF-Y master transcription factor complex.
      Title: Structural insights into the multivalent binding of the Arabidopsis FLOWERING LOCUS T promoter by the CO-NF-Y master transcription factor complex.
    5. The Arabidopsis histone demethylase JMJ28 regulates CONSTANS by interacting with FBH transcription factors.
      Title: The Arabidopsis histone demethylase JMJ28 regulates CONSTANS by interacting with FBH transcription factors.
    6. CONSTANS-FKBP12 interaction contributes to modulation of photoperiodic flowering in Arabidopsis.
      Title: CONSTANS-FKBP12 interaction contributes to modulation of photoperiodic flowering in Arabidopsis.
    7. A PIF7-CONSTANS-Centered Molecular Regulatory Network Underlying Shade-Accelerated Flowering
      Title: A PIF7-CONSTANS-Centered Molecular Regulatory Network Underlying Shade-Accelerated Flowering.
    8. PKL activates FT transcription likely through facilitating access of CO to FT chromatin at dusk to synchronize flowering time in response to environmental cues.
      Title: The chromatin-remodelling factor PICKLE interacts with CONSTANS to promote flowering in Arabidopsis.
    9. These observations are consistent with the long-standing but not demonstrated model where CO can inhibit FT induction of flowering by affecting TFL1 expression.
      Title: CONSTANS delays Arabidopsis flowering under short days.
    10. GI plays a pivotal role in CO stability for the precise control of flowering by coordinating balanced functional properties of FKF1 and ZTL.
      Title: GIGANTEA Regulates the Timing Stabilization of CONSTANS by Altering the Interaction between FKF1 and ZEITLUPE.
    Submit: New GeneRIF Correction See all GeneRIFs (54)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036810.2
    NM_121589.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within circadian rhythm IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within far-red light signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to far red light IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    B-box type zinc finger protein with CCT domain-containing protein
    NP_001031887.1
    • CONSTANS (CO); CONTAINS InterPro DOMAIN/s: Zinc finger, B-box (InterPro:IPR000315); BEST Arabidopsis thaliana protein match is: CONSTANS-like 2 (TAIR:AT3G02380.1); Has 2142 Blast hits to 1417 proteins in 117 species: Archae - 0; Bacteria - 0; Metazoa - 6; Fungi - 2; Plants - 2004; Viruses - 0; Other Eukaryotes - 130 (source: NCBI BLink).
    NP_197088.1
    • CONSTANS (CO); CONTAINS InterPro DOMAIN/s: CCT domain (InterPro:IPR010402), Zinc finger, B-box (InterPro:IPR000315); BEST Arabidopsis thaliana protein match is: CONSTANS-like 2 (TAIR:AT3G02380.1); Has 3403 Blast hits to 2554 proteins in 146 species: Archae - 0; Bacteria - 0; Metazoa - 118; Fungi - 2; Plants - 3122; Viruses - 0; Other Eukaryotes - 161 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5170162..5173085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121589.2 → NP_197088.1  B-box type zinc finger protein with CCT domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197088.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2V373, Q39057
      UniProtKB/TrEMBL
      A0A178UTB8, A0A5S9Y5C0
      Conserved Domains (2) summary
      cd19821
      Location:19 → 62
      Bbox1_BBX-like; B-box-type 1 zinc finger found in B-box (BBX) family of plant transcription factors and similar proteins
      pfam06203
      Location:306 → 349
      CCT; CCT motif

    2. NM_001036810.2 → NP_001031887.1  B-box type zinc finger protein with CCT domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031887.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39057
      Conserved Domains (2) summary
      smart00336
      Location:58 → 105
      BBOX; B-Box-type zinc finger
      cd00021
      Location:18 → 62
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39057.1

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