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    MRPL24 mitochondrial ribosomal protein L24 [ Homo sapiens (human) ]

    Gene ID: 79590, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MRPL24provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L24provided by HGNC
    Primary source
    HGNC:HGNC:14037
    See related
    Ensembl:ENSG00000143314 MIM:611836; AllianceGenome:HGNC:14037
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    L24mt; uL24m; MRP-L18; MRP-L24
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 29.6), adrenal (RPKM 28.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MRPL24 in Genome Data Viewer
    Location:
    1q23.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (156737303..156742716, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (155874136..155878130, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (156707095..156710880, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156674429-156674930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156676520-156677196 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156677875-156678551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156682885-156683400 Neighboring gene cellular retinoic acid binding protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1434 Neighboring gene interferon stimulated exonuclease gene 20 like 2 Neighboring gene methyltransferase like 25B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:156711011-156711988 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1877 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1878 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717051-156717748 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156717749-156718446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156718447-156719143 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156721068-156721842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156729657-156730190 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156730191-156730723 Neighboring gene heparin binding growth factor Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:156736100-156736726 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:156736727-156737352 Neighboring gene proline rich mitotic checkpoint control factor Neighboring gene Sharpr-MPRA regulatory region 3718 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156774267-156774768 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:156778787-156779288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:156783176-156783722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1438 Neighboring gene SH2 domain containing 2A Neighboring gene neurotrophic receptor tyrosine kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mammalian mitochondrial ribosomal proteins (4). Amino acid sequencing, characterization, and identification of corresponding gene sequences. O'Brien TW, et al. J Biol Chem, 2000 Jun 16. PMID 10751423
    2. GRSF1 regulates RNA processing in mitochondrial RNA granules. Jourdain AA, et al. Cell Metab, 2013 Mar 5. PMID 23473034, Free PMC Article
    3. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. Kenmochi N, et al. Genomics, 2001 Sep. PMID 11543634
    4. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
    5. TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment. Tian X, et al. Biochim Biophys Acta Mol Cell Res, 2023 Oct. PMID 37506885

    See all (82) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of mitochondrial ribosomal protein L24 (MRPL24) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC9831, FLJ20917, MGC22737

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of mitochondrial large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    large ribosomal subunit protein uL24m
    Names
    39S ribosomal protein L24, mitochondrial
    mitochondrial large ribosomal subunit protein uL24m

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024540.4 → NP_078816.2  large ribosomal subunit protein uL24m

      See identical proteins and their annotated locations for NP_078816.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. It encodes the same protein as variant 1.
      Source sequence(s)
      AA730909, BC012440
      Consensus CDS
      CCDS1155.1
      UniProtKB/Swiss-Prot
      D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
      UniProtKB/TrEMBL
      X6RJ73
      Related
      ENSP00000357194.4, ENST00000368211.8
      Conserved Domains (1) summary
      cd06089
      Location:59 → 122
      KOW_RPL26; KOW motif of Ribosomal Protein L26

    2. NM_145729.3 → NP_663781.1  large ribosomal subunit protein uL24m

      See identical proteins and their annotated locations for NP_663781.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the longer transcript and it encodes the same protein as variant 2.
      Source sequence(s)
      AA730909, BC016700, BG706700
      Consensus CDS
      CCDS1155.1
      UniProtKB/Swiss-Prot
      D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
      UniProtKB/TrEMBL
      X6RJ73
      Related
      ENSP00000354525.2, ENST00000361531.6
      Conserved Domains (1) summary
      cd06089
      Location:59 → 122
      KOW_RPL26; KOW motif of Ribosomal Protein L26

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      156737303..156742716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509982.3 → XP_011508284.1  large ribosomal subunit protein uL24m isoform X1

      See identical proteins and their annotated locations for XP_011508284.1

      UniProtKB/Swiss-Prot
      D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
      UniProtKB/TrEMBL
      X6RJ73
      Conserved Domains (1) summary
      cd06089
      Location:59 → 122
      KOW_RPL26; KOW motif of Ribosomal Protein L26

    2. XM_011509981.3 → XP_011508283.1  large ribosomal subunit protein uL24m isoform X1

      See identical proteins and their annotated locations for XP_011508283.1

      UniProtKB/Swiss-Prot
      D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
      UniProtKB/TrEMBL
      X6RJ73
      Conserved Domains (1) summary
      cd06089
      Location:59 → 122
      KOW_RPL26; KOW motif of Ribosomal Protein L26

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      155874136..155878130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338733.1 → XP_054194708.1  large ribosomal subunit protein uL24m isoform X1

      UniProtKB/Swiss-Prot
      D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
      UniProtKB/TrEMBL
      X6RJ73

    2. XM_054338732.1 → XP_054194707.1  large ribosomal subunit protein uL24m isoform X1

      UniProtKB/Swiss-Prot
      D3DVC8, Q53G65, Q53HT0, Q5SYZ9, Q5SZ00, Q5SZ02, Q96A35, Q96Q70, Q9H7G3
      UniProtKB/TrEMBL
      X6RJ73
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96A35.1 GenPept UniProtKB/Swiss-Prot:Q96A35

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