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    Pramel6 PRAME like 6 [ Mus musculus (house mouse) ]

    Gene ID: 347711, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pramel6provided by MGI
    Official Full Name
    PRAME like 6provided by MGI
    Primary source
    MGI:MGI:2156390
    See related
    Ensembl:ENSMUSG00000025838 AllianceGenome:MGI:2156390
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul2-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in blastocyst; compacted morula; and inner cell mass. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Pramel6 in Genome Data Viewer
    Location:
    2 D; 2 49.86 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (87336909..87341209)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (87506565..87510865)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 12 subfamily E member 7 Neighboring gene STARR-seq mESC enhancer starr_05041 Neighboring gene PRAME like 7 Neighboring gene STARR-seq mESC enhancer starr_05047 Neighboring gene olfactory receptor family 5 subfamily W member 9, pseudogene 1 Neighboring gene signal recognition particle 9 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3. Cinelli P, et al. BMC Dev Biol, 2008 May 23. PMID 18500982, Free PMC Article
    2. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Bortvin A, et al. Development, 2003 Apr. PMID 12620990
    3. Differences in gene expression between mouse and human for dynamically regulated genes in early embryo. Madissoon E, et al. PLoS One, 2014. PMID 25089626, Free PMC Article
    4. Mbd3, a component of the NuRD co-repressor complex, is required for development of pluripotent cells. Kaji K, et al. Development, 2007 Mar. PMID 17287250
    5. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul2-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    preferentially expressed antigen in melanoma like 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356544.1 → NP_001343473.1  preferentially expressed antigen in melanoma like 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AF490342, BY031404, CN720598
      Consensus CDS
      CCDS16294.1
      UniProtKB/TrEMBL
      Q3UT28, Q810Y9

    2. NM_001356545.1 → NP_001343474.1  preferentially expressed antigen in melanoma like 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AF490342, BG079990, BY031404
      Consensus CDS
      CCDS16294.1
      UniProtKB/TrEMBL
      Q3UT28, Q810Y9

    3. NM_001356546.1 → NP_001343475.1  preferentially expressed antigen in melanoma like 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AF490342, AL928797
      Consensus CDS
      CCDS16294.1
      UniProtKB/TrEMBL
      Q3UT28, Q810Y9
      Related
      ENSMUSP00000026956.4, ENSMUST00000026956.4

    4. NM_178249.3 → NP_839980.1  preferentially expressed antigen in melanoma like 6

      See identical proteins and their annotated locations for NP_839980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AF490342, AK139830
      Consensus CDS
      CCDS16294.1
      UniProtKB/TrEMBL
      Q3UT28, Q810Y9
      Related
      ENSMUSP00000107198.2, ENSMUST00000111572.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      87336909..87341209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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