U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SULT1A2 sulfotransferase family 1A member 2 [ Homo sapiens (human) ]

    Gene ID: 6799, updated on 3-Dec-2024

    Summary

    Official Symbol
    SULT1A2provided by HGNC
    Official Full Name
    sulfotransferase family 1A member 2provided by HGNC
    Primary source
    HGNC:HGNC:11454
    See related
    Ensembl:ENSG00000197165 MIM:601292; AllianceGenome:HGNC:11454
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STP2; HAST4; P-PST; ST1A2; TSPST2; P-PST 2
    Summary
    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in duodenum (RPKM 25.0), small intestine (RPKM 22.6) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SULT1A2 in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28591943..28597050, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28798642..28803752)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28603264..28608371, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr16:28549089-28550288 Neighboring gene nuclear protein 1, transcriptional regulator Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7310 Neighboring gene SAGA complex associated factor 29 Neighboring gene Sharpr-MPRA regulatory region 4245 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610237-28610771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28610772-28611305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28612139-28612653 Neighboring gene uncharacterized LOC107984835 Neighboring gene uncharacterized LOC124903674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28623750-28624250 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28624498-28625048 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28625049-28625598 Neighboring gene sulfotransferase family 1A member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28626587-28627161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10643 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7311 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7312 Neighboring gene nuclear pore complex interacting protein family member B8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
    EBI GWAS Catalog
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog
    Common variants at five new loci associated with early-onset inflammatory bowel disease.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC142287, MGC142289

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables aryl sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aryl sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables flavonol 3-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sulfotransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in amine biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in catecholamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ethanol catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phenol-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sulfation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in xenobiotic metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    sulfotransferase 1A2
    Names
    aryl sulfotransferase 2
    arylamine sulfotransferase
    phenol sulfotransferase 2
    phenol-preferring phenol sulfotransferase2
    phenol-sulfating phenol sulfotransferase 2
    phenolic-metabolizing (P) form of PST
    sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
    thermostable phenol sulfotransferase
    NP_001045.2
    NP_001350792.2
    NP_001387187.1
    NP_001387188.1
    NP_001387189.1
    NP_001387190.1
    NP_001387191.1
    NP_001387192.1
    NP_001387193.1
    NP_803564.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032570.2 RefSeqGene

      Range
      5000..10107
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001054.4NP_001045.2  sulfotransferase 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS10636.1
      UniProtKB/Swiss-Prot
      A9QY25, P50226, P78393, Q14CJ7
      UniProtKB/TrEMBL
      H3BRY5
      Related
      ENSP00000338742.4, ENST00000335715.9
      Conserved Domains (1) summary
      pfam00685
      Location:38287
      Sulfotransfer_1; Sulfotransferase domain
    2. NM_001363863.3NP_001350792.2  sulfotransferase 1A2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS86513.1
      UniProtKB/TrEMBL
      E9PKW4
      Related
      ENSP00000435271.1, ENST00000533150.5
    3. NM_001400258.1NP_001387187.1  sulfotransferase 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS10636.1
      UniProtKB/Swiss-Prot
      A9QY25, P50226, P78393, Q14CJ7
      UniProtKB/TrEMBL
      H3BRY5
    4. NM_001400259.1NP_001387188.1  sulfotransferase 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS10636.1
      UniProtKB/Swiss-Prot
      A9QY25, P50226, P78393, Q14CJ7
      UniProtKB/TrEMBL
      H3BRY5
    5. NM_001400260.1NP_001387189.1  sulfotransferase 1A2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC020765
      UniProtKB/TrEMBL
      H3BRY5
    6. NM_001400261.1NP_001387190.1  sulfotransferase 1A2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC020765
    7. NM_001400262.1NP_001387191.1  sulfotransferase 1A2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC020765
    8. NM_001400263.1NP_001387192.1  sulfotransferase 1A2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC020765
    9. NM_001400264.1NP_001387193.1  sulfotransferase 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS10636.1
      UniProtKB/Swiss-Prot
      A9QY25, P50226, P78393, Q14CJ7
      UniProtKB/TrEMBL
      H3BRY5
    10. NM_177528.4NP_803564.2  sulfotransferase 1A2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC020765
      Consensus CDS
      CCDS10636.1
      UniProtKB/Swiss-Prot
      A9QY25, P50226, P78393, Q14CJ7
      UniProtKB/TrEMBL
      H3BRY5
      Related
      ENSP00000378992.1, ENST00000395630.5
      Conserved Domains (1) summary
      pfam00685
      Location:38287
      Sulfotransfer_1; Sulfotransferase domain

    RNA

    1. NR_174455.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC020765

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      28591943..28597050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      28798642..28803752
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)