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    PRRG2 proline rich and Gla domain 2 [ Homo sapiens (human) ]

    Gene ID: 5639, updated on 9-Dec-2024

    Summary

    Official Symbol
    PRRG2provided by HGNC
    Official Full Name
    proline rich and Gla domain 2provided by HGNC
    Primary source
    HGNC:HGNC:9470
    See related
    Ensembl:ENSG00000126460 MIM:604429; AllianceGenome:HGNC:9470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRGP2
    Summary
    The protein encoded by this gene is a single-pass transmembrane protein containing an N-terminal gamma-carboxyglutamic acid (Gla) domain and tandem Pro/Leu-Pro-Xaa-Tyr (PY) motifs at its C-terminal end. The Gla domain is exposed on the cell surface while the PY motifs are cytoplasmic. The PY motifs of the encoded protein have been shown to interact with YAP1, a WW domain-containing protein. Therefore, it is thought that the encoded protein may be part of a signal transduction pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
    Expression
    Broad expression in duodenum (RPKM 5.0), thyroid (RPKM 4.3) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PRRG2 in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (49580617..49591004)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (52580649..52591029)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50084573..50094261)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50031176-50031754 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10920 Neighboring gene reticulocalbin 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50059309-50060090 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14948 Neighboring gene nitric oxide synthase interacting protein Neighboring gene ReSE screen-validated silencer GRCh37_chr19:50070496-50070674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50087865-50088490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10922 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10924 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:50095111-50095610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14950 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10925 Neighboring gene proline rich 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50135833-50136332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:50139452-50140018 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:50143247-50143916 Neighboring gene RAS related

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in blood coagulation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    transmembrane gamma-carboxyglutamic acid protein 2
    Names
    proline rich Gla (G-carboxyglutamic acid) 2
    proline-rich Gla (G-carboxglutamic acid) polypeptide 2
    proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
    proline-rich Gla protein 2
    proline-rich gamma-carboxyglutamic acid protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000951.3NP_000942.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_000942.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC010619, AF009243, CB851486, CD609900
      Consensus CDS
      CCDS12773.1
      UniProtKB/Swiss-Prot
      O14669, Q6IBF8
      Related
      ENSP00000246794.4, ENST00000246794.10
      Conserved Domains (2) summary
      cd12087
      Location:109138
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      smart00069
      Location:2895
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    2. NM_001316335.2NP_001303264.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction near the 5' end compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC010619, CB851486, CD013954, CD609900
      Related
      ENST00000543867.2
      Conserved Domains (2) summary
      cd12087
      Location:86115
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      smart00069
      Location:572
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      49580617..49591004
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006723286.2XP_006723349.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006723349.1

      UniProtKB/Swiss-Prot
      O14669, Q6IBF8
      Conserved Domains (2) summary
      cd12087
      Location:109138
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      smart00069
      Location:2895
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    2. XM_011527124.2XP_011525426.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform X2

      See identical proteins and their annotated locations for XP_011525426.1

      Conserved Domains (2) summary
      cd12087
      Location:86115
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      smart00069
      Location:572
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      52580649..52591029
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321475.1XP_054177450.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform X1

    2. XM_054321476.1XP_054177451.1  transmembrane gamma-carboxyglutamic acid protein 2 isoform X2

      UniProtKB/TrEMBL
      Q8TAS3