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    CSPG4 chondroitin sulfate proteoglycan 4 [ Homo sapiens (human) ]

    Gene ID: 1464, updated on 9-Dec-2024

    Summary

    Official Symbol
    CSPG4provided by HGNC
    Official Full Name
    chondroitin sulfate proteoglycan 4provided by HGNC
    Primary source
    HGNC:HGNC:2466
    See related
    Ensembl:ENSG00000173546 MIM:601172; AllianceGenome:HGNC:2466
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NG2; MCSP; MCSPG; MSK16; CSPG4A; HMW-MAA; MEL-CSPG
    Summary
    A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 18.8), placenta (RPKM 10.9) and 19 other tissues See more
    Orthologs
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    Genomic context

    See CSPG4 in Genome Data Viewer
    Location:
    15q24.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (75674322..75713466, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (73545032..73584178, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75966663..76005189, complement)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6676 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75940037-75940728 Neighboring gene IMP U3 small nucleolar ribonucleoprotein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75943426-75944362 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75945327-75945879 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75945880-75946431 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75949231-75949732 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75949733-75950232 Neighboring gene sorting nexin 33 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75952205-75952778 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:75953927-75954500 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75966659-75967446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75974798-75975642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75978522-75979027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75979028-75979532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75985202-75985952 Neighboring gene Sharpr-MPRA regulatory region 4583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75989701-75990450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75990451-75991198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6679 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:75993083-75993582 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:75993590-75994515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76019661-76020161 Neighboring gene ciliary microtubule associated protein 1C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76023672-76024603 Neighboring gene dynamin 1 pseudogene 35 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:76028296-76028816 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6681 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9864 Neighboring gene peptidylprolyl isomerase A pseudogene 47

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables coreceptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in platelet-derived growth factor receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ruffle assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in substrate-dependent cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tissue remodeling IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    chondroitin sulfate proteoglycan 4
    Names
    chondroitin sulfate proteoglycan 4 (melanoma-associated)
    chondroitin sulfate proteoglycan NG2
    melanoma chondroitin sulfate proteoglycan
    melanoma-associated chondroitin sulfate proteoglycan

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001897.5NP_001888.2  chondroitin sulfate proteoglycan 4 precursor

      See identical proteins and their annotated locations for NP_001888.2

      Status: REVIEWED

      Source sequence(s)
      AY359468, BP363063, BQ679485, CA428796, CA438367, X96753
      Consensus CDS
      CCDS10284.1
      UniProtKB/Swiss-Prot
      D3DW77, Q6UVK1, Q92675
      Related
      ENSP00000312506.5, ENST00000308508.5
      Conserved Domains (2) summary
      cd00110
      Location:203361
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam16184
      Location:14201563
      Cadherin_3; Cadherin-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      75674322..75713466 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432196.1XP_047288152.1  chondroitin sulfate proteoglycan 4 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      73545032..73584178 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377370.1XP_054233345.1  chondroitin sulfate proteoglycan 4 isoform X1