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    Gas6 growth arrest specific 6 [ Mus musculus (house mouse) ]

    Gene ID: 14456, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gas6provided by MGI
    Official Full Name
    growth arrest specific 6provided by MGI
    Primary source
    MGI:MGI:95660
    See related
    Ensembl:ENSMUSG00000031451 AllianceGenome:MGI:95660
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gas-6
    Summary
    Enables receptor ligand activity. Involved in negative regulation of apoptotic process. Acts upstream of or within several processes, including blood coagulation; negative regulation of apoptotic process; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in extracellular space. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and limb. Orthologous to human GAS6 (growth arrest specific 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 548.6), adrenal adult (RPKM 311.4) and 15 other tissues See more
    Orthologs
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    Genomic context

    See Gas6 in Genome Data Viewer
    Location:
    8 A1.1; 8 6.06 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13515374..13544535, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13465374..13494535, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ATPase, H+/K+ exchanging, beta polypeptide Neighboring gene G protein-coupled receptor kinase 1 Neighboring gene transmembrane protein 255B Neighboring gene predicted gene, 53399 Neighboring gene RIKEN cDNA 1700029H14 gene Neighboring gene STARR-seq mESC enhancer starr_20769 Neighboring gene RAS p21 protein activator 3 Neighboring gene predicted gene, 34795

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process  
    enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process  
    enables phosphatidylserine binding  
    enables phosphatidylserine binding  
    enables protein-macromolecule adaptor activity  
    enables protein-macromolecule adaptor activity  
    enables receptor ligand activity  
    enables receptor ligand activity PubMed 
    enables receptor ligand activity  
    enables receptor ligand activity  
    enables receptor tyrosine kinase binding  
    enables receptor tyrosine kinase binding  
    enables signaling receptor binding  
    enables signaling receptor binding  
    Items 1 - 25 of 106
    Process Evidence Code Pubs
    involved_in B cell chemotaxis  
    involved_in B cell chemotaxis  
    involved_in activation of protein kinase B activity  
    involved_in animal organ regeneration  
    acts_upstream_of_or_within apoptotic cell clearance PubMed 
    involved_in apoptotic cell clearance  
    acts_upstream_of apoptotic process PubMed 
    acts_upstream_of_or_within blood coagulation PubMed 
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transmembrane transport  
    involved_in cell surface receptor signaling pathway  
    acts_upstream_of_or_within cell-substrate adhesion PubMed 
    involved_in cellular response to glucose stimulus  
    involved_in cellular response to glucose stimulus  
    acts_upstream_of_or_within cellular response to growth factor stimulus PubMed 
    acts_upstream_of_or_within cellular response to growth factor stimulus PubMed 
    involved_in cellular response to interferon-alpha  
    involved_in cellular response to interferon-alpha  
    acts_upstream_of_or_within cellular response to starvation PubMed 
    involved_in cellular response to vitamin K  
    involved_in cellular response to vitamin K  
    involved_in cellular response to xenobiotic stimulus  
    involved_in cellular response to xenobiotic stimulus  
    involved_in dendritic cell differentiation  
    acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway PubMed 
    involved_in extracellular matrix assembly  
    acts_upstream_of fibroblast apoptotic process PubMed 
    involved_in fusion of virus membrane with host plasma membrane  
    involved_in fusion of virus membrane with host plasma membrane  
    involved_in hematopoietic stem cell migration to bone marrow  
    involved_in hematopoietic stem cell migration to bone marrow  
    acts_upstream_of_or_within macrophage cytokine production PubMed 
    acts_upstream_of myeloid cell apoptotic process PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription  
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process PubMed 
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of biomineral tissue development  
    involved_in negative regulation of biomineral tissue development  
    involved_in negative regulation of cysteine-type endopeptidase activity  
    involved_in negative regulation of cysteine-type endopeptidase activity  
    involved_in negative regulation of dendritic cell apoptotic process  
    involved_in negative regulation of dendritic cell apoptotic process  
    involved_in negative regulation of endothelial cell apoptotic process  
    involved_in negative regulation of endothelial cell apoptotic process  
    acts_upstream_of_or_within negative regulation of fibroblast apoptotic process PubMed 
    involved_in negative regulation of fibroblast apoptotic process  
    involved_in negative regulation of fibroblast apoptotic process  
    involved_in negative regulation of interleukin-1 production  
    involved_in negative regulation of interleukin-1 production  
    involved_in negative regulation of interleukin-6 production  
    involved_in negative regulation of interleukin-6 production  
    acts_upstream_of_or_within negative regulation of myeloid cell apoptotic process PubMed 
    involved_in negative regulation of oligodendrocyte apoptotic process  
    involved_in negative regulation of oligodendrocyte apoptotic process  
    involved_in negative regulation of renal albumin absorption  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of tumor necrosis factor production  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in negative regulation of tumor necrosis factor-mediated signaling pathway  
    involved_in negative regulation of type II interferon production  
    involved_in negative regulation of type II interferon production  
    acts_upstream_of_or_within neuron migration PubMed 
    involved_in phagocytosis  
    involved_in phagocytosis  
    acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of TOR signaling  
    involved_in positive regulation of TOR signaling  
    involved_in positive regulation of cytokine-mediated signaling pathway  
    involved_in positive regulation of cytokine-mediated signaling pathway  
    involved_in positive regulation of dendritic cell chemotaxis  
    involved_in positive regulation of dendritic cell chemotaxis  
    acts_upstream_of_or_within positive regulation of fibroblast proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of fibroblast proliferation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of glomerular filtration  
    involved_in positive regulation of glomerular filtration  
    involved_in positive regulation of natural killer cell differentiation  
    involved_in positive regulation of natural killer cell differentiation  
    involved_in positive regulation of phagocytosis  
    involved_in positive regulation of phagocytosis  
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of protein export from nucleus  
    involved_in positive regulation of protein export from nucleus  
    involved_in positive regulation of protein kinase activity  
    involved_in positive regulation of protein kinase activity  
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein phosphorylation  
    involved_in protein localization to plasma membrane  
    involved_in protein localization to plasma membrane  
    involved_in protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in receptor-mediated virion attachment to host cell  
    involved_in receptor-mediated virion attachment to host cell  
    involved_in signal transduction  
    involved_in symbiont entry into host cell  
    involved_in symbiont entry into host cell  
    involved_in viral genome replication  
    involved_in viral genome replication  
    Items 1 - 25 of 106
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in extracellular space PubMed 
    located_in extracellular space PubMed 
    located_in extracellular space PubMed 

    General protein information

    Preferred Names
    growth arrest-specific protein 6
    Names
    AXL receptor tyrosine kinase ligand

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019521.2NP_062394.2  growth arrest-specific protein 6 precursor

      See identical proteins and their annotated locations for NP_062394.2

      Status: VALIDATED

      Source sequence(s)
      AI482478, AK086187, CJ062651, X59846
      Consensus CDS
      CCDS40232.1
      UniProtKB/Swiss-Prot
      Q61592, Q99K57
      Related
      ENSMUSP00000033828.6, ENSMUST00000033828.7
      Conserved Domains (7) summary
      smart00069
      Location:2690
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      smart00179
      Location:194225
      EGF_CA; Calcium-binding EGF-like domain
      cd00054
      Location:115150
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:295447
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam02210
      Location:510647
      Laminin_G_2; Laminin G domain
      pfam12662
      Location:215238
      cEGF; Complement Clr-like EGF-like
      pfam14670
      Location:157192
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13515374..13544535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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