Ndufb8 NADH:ubiquinone oxidoreductase subunit B8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ndufb8provided by MGI
Official Full Name: NADH:ubiquinone oxidoreductase subunit B8provided by MGI
Primary source: MGI:MGI:1914514
See related: Ensembl:ENSMUSG00000025204 AllianceGenome:MGI:1914514
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CI-ASHI; 2900010I05Rik
Summary: Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Part of respiratory chain complex I. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 32. Orthologous to human NDUFB8 (NADH:ubiquinone oxidoreductase subunit B8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in heart adult (RPKM 237.7), kidney adult (RPKM 174.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 37.98 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (44537010..44543881, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (44548571..44555442, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study reports mitochondrial dysfunction in TgCRND8 mouse model of Alzheimer's disease and identifies the NDUFB8 subunit of complex I as a key target of A-beta toxicity
Title: Reduced levels of mitochondrial complex I subunit NDUFB8 and linked complex I + III oxidoreductase activity in the TgCRND8 mouse model of Alzheimer's disease.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
involved_in mitochondrial electron transport, NADH to ubiquinone	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
is_active_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	IDA Inferred from Direct Assay more info	PubMed
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial

Names: NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8; NADH-ubiquinone oxidoreductase ASHI subunit; complex I-ASHI

NP_001334376.1

EC 1.6.99.3

NP_080337.1

EC 1.6.99.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347447.1 → NP_001334376.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC151478

Consensus CDS

CCDS84446.1

UniProtKB/TrEMBL

Q3V406

Related

ENSMUSP00000128192.2, ENSMUST00000171415.8
NM_026061.3 → NP_080337.1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_080337.1

Status: VALIDATED

Source sequence(s)

AC151478

Consensus CDS

CCDS29851.1

UniProtKB/Swiss-Prot

Q9D6J5, Q9D6M7

Related

ENSMUSP00000026222.5, ENSMUST00000026222.11

Conserved Domains (1) summary

pfam05821
Location:21 → 186

NDUF_B8; NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)