U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Tbc1d2 TBC1 domain family, member 2 [ Mus musculus (house mouse) ]

    Gene ID: 381605, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tbc1d2provided by MGI
    Official Full Name
    TBC1 domain family, member 2provided by MGI
    Primary source
    MGI:MGI:2652885
    See related
    Ensembl:ENSMUSG00000039813 AllianceGenome:MGI:2652885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1037; PARIS1; PARIS-1; A630005A06Rik
    Summary
    Predicted to enable GTPase activator activity and cadherin binding activity. Predicted to be involved in positive regulation of GTPase activity. Predicted to be located in several cellular components, including cytoplasmic vesicle; cytosol; and nucleoplasm. Orthologous to human TBC1D2 (TBC1 domain family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 17.6), bladder adult (RPKM 7.1) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tbc1d2 in Genome Data Viewer
    Location:
    4 B1; 4 25.04 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (46604390..46650396, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (46604390..46650340, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 14 Neighboring gene STARR-positive B cell enhancer ABC_E4623 Neighboring gene predicted gene, 16731 Neighboring gene coronin, actin binding protein 2A Neighboring gene STARR-positive B cell enhancer ABC_E3489 Neighboring gene STARR-positive B cell enhancer ABC_E3490 Neighboring gene STARR-positive B cell enhancer ABC_E6173 Neighboring gene STARR-positive B cell enhancer ABC_E2111 Neighboring gene predicted gene, 54221 Neighboring gene predicted gene, 54222 Neighboring gene predicted gene, 31850 Neighboring gene predicted gene, 42281 Neighboring gene STARR-seq mESC enhancer starr_10135 Neighboring gene gamma-aminobutyric acid type B receptor subunit 2 Neighboring gene predicted gene, 32208 Neighboring gene predicted gene, 32135

    Genomic regions, transcripts, and products

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables GTPase activator activity  
    enables cadherin binding  
    enables cadherin binding  
    Component Evidence Code Pubs
    located_in anchoring junction  
    located_in cell junction  
    located_in cell junction  
    is_active_in cytoplasm  
    located_in cytoplasmic vesicle  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    TBC1 domain family member 2A
    Names
    likely ortholog of H. sapiens TBC1 domain family, member 2 (TBC1D2)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198664.3NP_941066.3  TBC1 domain family member 2A

      See identical proteins and their annotated locations for NP_941066.3

      Status: VALIDATED

      Source sequence(s)
      AL683884, BX571848, BX682536
      Consensus CDS
      CCDS18155.1
      UniProtKB/Swiss-Prot
      B1AVH7, Q3UFW9, Q8BYB1
      Related
      ENSMUSP00000081670.6, ENSMUST00000084621.12
      Conserved Domains (3) summary
      smart00164
      Location:619831
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01265
      Location:45146
      PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
      pfam00169
      Location:45138
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      46604390..46650396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538047.5XP_006538110.1  TBC1 domain family member 2A isoform X2

      Conserved Domains (4) summary
      smart00164
      Location:620832
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG4913
      Location:300565
      COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
      PRK14951
      Location:192404
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd01265
      Location:45146
      PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
    2. XM_006538046.5XP_006538109.1  TBC1 domain family member 2A isoform X1

      Conserved Domains (4) summary
      smart00164
      Location:620832
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG4913
      Location:300565
      COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
      PRK14951
      Location:192404
      PRK14951; DNA polymerase III subunits gamma and tau; Provisional
      cd01265
      Location:45146
      PH_TBC1D2A; TBC1 domain family member 2A pleckstrin homology (PH) domain
    3. XM_036164218.1XP_036020111.1  TBC1 domain family member 2A isoform X3

      Conserved Domains (2) summary
      smart00164
      Location:399611
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG4913
      Location:79319
      COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
    4. XM_030253640.1XP_030109500.1  TBC1 domain family member 2A isoform X4

      Conserved Domains (1) summary
      smart00164
      Location:163375
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    5. XM_006538050.2XP_006538113.1  TBC1 domain family member 2A isoform X5

      Conserved Domains (3) summary
      smart00164
      Location:475687
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG4913
      Location:155395
      COG4913; Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown]
      pfam15730
      Location:84151
      DUF4680; Domain of unknown function (DUF4680)
    6. XM_006538049.1XP_006538112.1  TBC1 domain family member 2A isoform X4

      Conserved Domains (1) summary
      smart00164
      Location:163375
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    External link. Please review our privacy policy.