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    Ndufb7 NADH:ubiquinone oxidoreductase subunit B7 [ Mus musculus (house mouse) ]

    Gene ID: 66916, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ndufb7provided by MGI
    Official Full Name
    NADH:ubiquinone oxidoreductase subunit B7provided by MGI
    Primary source
    MGI:MGI:1914166
    See related
    Ensembl:ENSMUSG00000033938 AllianceGenome:MGI:1914166
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110002H15Rik
    Summary
    Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Is expressed in several structures, including alimentary system; heart; nervous system; respiratory system; and urinary system. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency. Orthologous to human NDUFB7 (NADH:ubiquinone oxidoreductase subunit B7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 332.5), duodenum adult (RPKM 247.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ndufb7 in Genome Data Viewer
    Location:
    8 C2; 8 40.22 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (84293387..84298252)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (83566758..83571623)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily K member 2 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_22086 Neighboring gene STARR-positive B cell enhancer ABC_E6666 Neighboring gene RIKEN cDNA D830024N08 gene Neighboring gene trans-2,3-enoyl-CoA reductase Neighboring gene predicted gene, 51541 Neighboring gene STARR-positive B cell enhancer ABC_E454 Neighboring gene predicted gene, 42029 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preserved respiratory chain capacity and physiology in mice with profoundly reduced levels of mitochondrial respirasomes. Milenkovic D, et al. Cell Metab, 2023 Oct 3. PMID 37633273
    2. Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics. Ponce JM, et al. J Am Heart Assoc, 2020 Apr 7. PMID 32248761, Free PMC Article
    3. IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Dai N, et al. Cell Metab, 2015 Apr 7. PMID 25863250, Free PMC Article
    4. Chronic Activation of γ2 AMPK Induces Obesity and Reduces β Cell Function. Yavari A, et al. Cell Metab, 2016 May 10. PMID 27133129, Free PMC Article
    5. Region-specific expression of mitochondrial complex I genes during murine brain development. Wirtz S, et al. PLoS One, 2011 Apr 27. PMID 21556144, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADH dehydrogenase (ubiquinone) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in aerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proton motive force-driven mitochondrial ATP synthesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    is_active_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7
    Names
    CI-B18
    NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7
    NADH-ubiquinone oxidoreductase B18 subunit
    complex I-B18
    NP_080119.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025843.3 → NP_080119.1  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

      See identical proteins and their annotated locations for NP_080119.1

      Status: VALIDATED

      Source sequence(s)
      AC151992
      Consensus CDS
      CCDS22455.1
      UniProtKB/Swiss-Prot
      Q9CR61
      Related
      ENSMUSP00000037341.6, ENSMUST00000036996.6
      Conserved Domains (1) summary
      pfam05676
      Location:41 → 100
      NDUF_B7; NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      84293387..84298252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CR61.3 GenPept UniProtKB/Swiss-Prot:Q9CR61

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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