U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rph3al rabphilin 3A-like (without C2 domains) [ Mus musculus (house mouse) ]

    Gene ID: 380714, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rph3alprovided by MGI
    Official Full Name
    rabphilin 3A-like (without C2 domains)provided by MGI
    Primary source
    MGI:MGI:1923492
    See related
    Ensembl:ENSMUSG00000020847 AllianceGenome:MGI:1923492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Noc2; Gm1753
    Summary
    Predicted to enable LIM domain binding activity. Involved in glucose homeostasis and positive regulation of insulin secretion. Acts upstream of or within negative regulation of G protein-coupled receptor signaling pathway and regulation of calcium ion-dependent exocytosis. Predicted to be located in secretory granule. Predicted to be active in synapse. Orthologous to human RPH3AL (rabphilin 3A like (without C2 domains)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 6.6), stomach adult (RPKM 5.2) and 21 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rph3al in Genome Data Viewer
    Location:
    11 B5; 11 45.92 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75721818..75858440, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75830992..75967614, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8425 Neighboring gene predicted gene, 57767 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide Neighboring gene STARR-seq mESC enhancer starr_30005 Neighboring gene STARR-positive B cell enhancer ABC_E5247 Neighboring gene double C2, beta Neighboring gene STARR-seq mESC enhancer starr_30008 Neighboring gene predicted gene 12339 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:75790377-75790632 Neighboring gene STARR-positive B cell enhancer ABC_E10691 Neighboring gene STARR-seq mESC enhancer starr_30012 Neighboring gene ligand of ATE1 Neighboring gene refilin B

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells. Ogata S, et al. PLoS One, 2012. PMID 22615885, Free PMC Article
    2. Cellular expression of Noc2, a Rab effector protein, in endocrine and exocrine tissues in the mouse. Teramae H, et al. Histochem Cell Biol, 2007 Jan. PMID 16835753
    3. Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2. Matsunaga K, et al. J Cell Sci, 2017 Feb 1. PMID 27927751
    4. Rab3a is involved in transport of synaptic vesicles to the active zone in mouse brain nerve terminals. Leenders AG, et al. Mol Biol Cell, 2001 Oct. PMID 11598194, Free PMC Article
    5. Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. Matsumoto M, et al. Proc Natl Acad Sci U S A, 2004 Jun 1. PMID 15159548, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that the dual effector, Noc2, regulates the transition from Rab2a-mediated granule biogenesis to Rab27a-mediated granule exocytosis.
      Title: Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2.
    2. In pancreatic acinar cells, Noc2 is not indispensable for the membrane fusion of ZG per se, but instead performs a novel function favoring agonist-induced physiological [Ca(2+)](i) increases.
      Title: A novel function of Noc2 in agonist-induced intracellular Ca2+ increase during zymogen-granule exocytosis in pancreatic acinar cells.
    3. investigated localization of Noc2 immunohistochemically in various endocrine and exocrine tissues in normal mice, including pancreatic islets, the adrenal gland, pituitary gland, salivary gland, and thyroid gland
      Title: Cellular expression of Noc2, a Rab effector protein, in endocrine and exocrine tissues in the mouse.
    4. Results show that Noc2, a critical effector of Rab3, is essential in normal regulation of exocytosis in both endocrine and exocrine cells.
      Title: Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • 6530413F01Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables LIM domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables LIM domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium-dependent activation of synaptic vesicle fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glucose homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of G protein-coupled receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of calcium ion-dependent exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of calcium ion-dependent exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in secretory granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    rab effector Noc2
    Names
    no C2 domains protein
    rabphilin-3A-like protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291159.1 → NP_001278088.1  rab effector Noc2 isoform 2

      See identical proteins and their annotated locations for NP_001278088.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks several exons, and uses an alternate 3'-terminal exon, compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK018335, CO800159, DV653859
      Consensus CDS
      CCDS70243.1
      UniProtKB/Swiss-Prot
      Q768S4
      Related
      ENSMUSP00000021208.5, ENSMUST00000021208.11
      Conserved Domains (1) summary
      cl22851
      Location:45 → 117
      PHD_SF; PHD finger superfamily

    2. NM_029548.4 → NP_083824.1  rab effector Noc2 isoform 1

      See identical proteins and their annotated locations for NP_083824.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA616014, AI594476, BQ176035, BU610075, BX631599, DV651301, DV660756
      Consensus CDS
      CCDS25058.1
      UniProtKB/Swiss-Prot
      Q768S4, Q9D353
      Related
      ENSMUSP00000064202.5, ENSMUST00000066504.11
      Conserved Domains (1) summary
      pfam02318
      Location:45 → 159
      FYVE_2; FYVE-type zinc finger

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75721818..75858440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533643.2 → XP_006533706.1  rab effector Noc2 isoform X2

      Conserved Domains (1) summary
      cl22851
      Location:45 → 130
      PHD_SF; PHD finger superfamily

    2. XM_006533637.2 → XP_006533700.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533700.1

      UniProtKB/Swiss-Prot
      Q768S4, Q9D353
      Conserved Domains (1) summary
      pfam02318
      Location:45 → 159
      FYVE_2; FYVE-type zinc finger

    3. XM_006533638.5 → XP_006533701.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533701.1

      UniProtKB/Swiss-Prot
      Q768S4, Q9D353
      Related
      ENSMUSP00000113869.2, ENSMUST00000121287.8
      Conserved Domains (1) summary
      pfam02318
      Location:45 → 159
      FYVE_2; FYVE-type zinc finger

    4. XM_006533640.5 → XP_006533703.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533703.1

      UniProtKB/Swiss-Prot
      Q768S4, Q9D353
      Conserved Domains (1) summary
      pfam02318
      Location:45 → 159
      FYVE_2; FYVE-type zinc finger

    5. XM_006533642.5 → XP_006533705.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533705.1

      UniProtKB/Swiss-Prot
      Q768S4, Q9D353
      Conserved Domains (1) summary
      pfam02318
      Location:45 → 159
      FYVE_2; FYVE-type zinc finger

    6. XM_030246103.1 → XP_030101963.1  rab effector Noc2 isoform X2

      Conserved Domains (1) summary
      cl22851
      Location:45 → 130
      PHD_SF; PHD finger superfamily

    7. XM_006533639.4 → XP_006533702.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533702.1

      UniProtKB/Swiss-Prot
      Q768S4, Q9D353
      Conserved Domains (1) summary
      pfam02318
      Location:45 → 159
      FYVE_2; FYVE-type zinc finger

    8. XM_006533641.5 → XP_006533704.1  rab effector Noc2 isoform X1

      See identical proteins and their annotated locations for XP_006533704.1

      UniProtKB/Swiss-Prot
      Q768S4, Q9D353
      Conserved Domains (1) summary
      pfam02318
      Location:45 → 159
      FYVE_2; FYVE-type zinc finger

    9. XM_011249100.3 → XP_011247402.1  rab effector Noc2 isoform X3

      Conserved Domains (1) summary
      pfam02318
      Location:45 → 159
      FYVE_2; FYVE-type zinc finger

    10. XM_011249101.2 → XP_011247403.1  rab effector Noc2 isoform X4

      See identical proteins and their annotated locations for XP_011247403.1

      UniProtKB/Swiss-Prot
      Q768S4
      Conserved Domains (1) summary
      cl22851
      Location:45 → 117
      PHD_SF; PHD finger superfamily

    11. XM_011249102.2 → XP_011247404.1  rab effector Noc2 isoform X4

      See identical proteins and their annotated locations for XP_011247404.1

      UniProtKB/Swiss-Prot
      Q768S4
      Related
      ENSMUSP00000104058.3, ENSMUST00000108420.9
      Conserved Domains (1) summary
      cl22851
      Location:45 → 117
      PHD_SF; PHD finger superfamily

    RNA

    1. XR_388486.2 RNA Sequence

    2. XR_003949467.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q768S4.1 GenPept UniProtKB/Swiss-Prot:Q768S4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools