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    Ercc6l excision repair cross-complementing rodent repair deficiency complementation group 6 like [ Mus musculus (house mouse) ]

    Gene ID: 236930, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ercc6lprovided by MGI
    Official Full Name
    excision repair cross-complementing rodent repair deficiency complementation group 6 likeprovided by MGI
    Primary source
    MGI:MGI:2654144
    See related
    Ensembl:ENSMUSG00000051220 AllianceGenome:MGI:2654144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D330021P09Rik
    Summary
    Predicted to enable DNA translocase activity. Predicted to be involved in DNA repair. Predicted to be located in kinetochore. Is expressed in several structures, including adrenal medulla; liver; lung; nervous system; and trunk. Orthologous to human ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver E14 (RPKM 4.8), CNS E11.5 (RPKM 4.2) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ercc6l in Genome Data Viewer
    Location:
    X D; X 45.16 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (101186426..101200697, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (102142820..102157091, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin) Neighboring gene high mobility group protein B1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2538 Neighboring gene protein phosphatase 1 regulatory subunit 14B pseudogene Neighboring gene ribosomal protein S4, X-linked

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ercc6l, a gene of SNF2 family, may play a role in the teratogenic action of alcohol. Xu Y, et al. Toxicol Lett, 2005 Jul 4. PMID 15917148
    2. Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality. Albers E, et al. Cell Rep, 2018 Sep 18. PMID 30232008, Free PMC Article
    3. Gene expression profiling identifies eleven DNA repair genes down-regulated during mouse neural crest cell migration. Albino D, et al. Int J Dev Biol, 2011. PMID 21425081
    4. PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response. Geng X, et al. Adv Sci (Weinh), 2022 Mar. PMID 35037428, Free PMC Article
    5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ercc6l is essential to preserve chromosomal integrity during embryonic development.
      Title: Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7766

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA translocase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA translocase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA translocase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA excision repair protein ERCC-6-like
    Names
    ATP-dependent helicase ERCC6-like
    SNF2/RAD54 family protein
    excision repair cross-complementing rodent repair deficiency complementation group 6 - like
    NP_666347.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146235.3 → NP_666347.2  DNA excision repair protein ERCC-6-like

      See identical proteins and their annotated locations for NP_666347.2

      Status: VALIDATED

      Source sequence(s)
      AK029015, AL807784
      Consensus CDS
      CCDS30321.1
      UniProtKB/Swiss-Prot
      Q8BGN1, Q8BHK9, Q8BRC9, Q8CE49
      Related
      ENSMUSP00000050592.3, ENSMUST00000056904.3
      Conserved Domains (3) summary
      cd00046
      Location:117 → 260
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00176
      Location:100 → 418
      SNF2_N; SNF2 family N-terminal domain
      pfam00271
      Location:462 → 577
      Helicase_C; Helicase conserved C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      101186426..101200697 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHK9.1 GenPept UniProtKB/Swiss-Prot:Q8BHK9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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