U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Med12l mediator complex subunit 12-like [ Mus musculus (house mouse) ]

    Gene ID: 329650, updated on 9-Dec-2024

    Summary

    Official Symbol
    Med12lprovided by MGI
    Official Full Name
    mediator complex subunit 12-likeprovided by MGI
    Primary source
    MGI:MGI:2139916
    See related
    Ensembl:ENSMUSG00000056476 AllianceGenome:MGI:2139916
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TRALPUSH; A130035F20; A630079M02
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be part of mediator complex. Orthologous to human MED12L (mediator complex subunit 12L). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 4.7), CNS E18 (RPKM 3.5) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Med12l in Genome Data Viewer
    Location:
    3 D; 3 28.89 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (58912820..59225867)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (59005419..59318446)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L13, pseudogene 6 Neighboring gene predicted gene, 25572 Neighboring gene STARR-positive B cell enhancer ABC_E6054 Neighboring gene STARR-seq mESC enhancer starr_07762 Neighboring gene STARR-seq mESC enhancer starr_07763 Neighboring gene G protein-coupled receptor 171 Neighboring gene RIKEN cDNA F630111L10 gene Neighboring gene purinergic receptor P2Y, G-protein coupled, 14 Neighboring gene STARR-seq mESC enhancer starr_07764 Neighboring gene STARR-seq mESC enhancer starr_07765 Neighboring gene predicted gene, 51434 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y, G-protein coupled 13 Neighboring gene purinergic receptor P2Y, G-protein coupled 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:59062055-59062302 Neighboring gene STARR-seq mESC enhancer starr_07766 Neighboring gene immunoglobulin superfamily, member 10 Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene nuclear encoded tRNA valine 1 (anticodon CAC)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables beta-catenin binding  
    enables transcription coactivator activity  
    enables transcription coregulator activity  
    enables transcription factor binding PubMed 
    Component Evidence Code Pubs
    part_of mediator complex  
    part_of mediator complex  

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 12-like protein
    Names
    mediator complex subunit 12-like protein
    mediator of RNA polymerase II transcription, subunit 12 homolog-like
    no opposite paired repeat protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177855.3NP_808523.2  mediator of RNA polymerase II transcription subunit 12-like protein

      Status: VALIDATED

      Source sequence(s)
      AA409741, AC122038, AK018323, AK037666, AK047743, BB646790, BP757618, BP757619, CA316095, CA318113, CB520516, CK638338
      Consensus CDS
      CCDS79912.1
      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      UniProtKB/TrEMBL
      A0A0G2JET8
      Related
      ENSMUSP00000142903.2, ENSMUST00000199659.5
      Conserved Domains (3) summary
      pfam09497
      Location:106161
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18382062
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:283765
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      58912820..59225867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252646.2XP_030108506.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18492073
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    2. XM_036163137.1XP_036019030.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18142040
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294741
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    3. XM_017319618.3XP_017175107.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X11

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18491931
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    4. XM_006501593.5XP_006501656.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X10

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18491931
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    5. XM_006501592.5XP_006501655.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X9

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18492068
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    6. XM_006501589.5XP_006501652.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X6

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18492073
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    7. XM_006501591.5XP_006501654.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X8

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18492068
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    8. XM_030252645.2XP_030108505.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18492073
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    9. XM_030252647.2XP_030108507.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X4

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      UniProtKB/TrEMBL
      A0A0G2JET8
      Conserved Domains (3) summary
      pfam09497
      Location:106161
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18382062
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:283765
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    10. XM_006501587.5XP_006501650.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X3

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18442068
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    11. XM_006501586.5XP_006501649.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X2

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18482072
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294776
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    12. XM_006501588.5XP_006501651.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18142040
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294741
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    13. XM_030252649.2XP_030108509.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X7

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106161
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18032027
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:283730
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    14. XM_030252648.1XP_030108508.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

      UniProtKB/Swiss-Prot
      Q6ZPF2, Q8BQM9, Q8C9E3
      Conserved Domains (3) summary
      pfam09497
      Location:106172
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18142040
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:294741
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    RNA

    1. XR_004941335.1 RNA Sequence

    2. XR_004941334.1 RNA Sequence

    3. XR_003954333.2 RNA Sequence

    4. XR_375531.5 RNA Sequence

    External link. Please review our privacy policy.