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    Zbtb34 zinc finger and BTB domain containing 34 [ Mus musculus (house mouse) ]

    Gene ID: 241311, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb34provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 34provided by MGI
    Primary source
    MGI:MGI:2685195
    See related
    Ensembl:ENSMUSG00000068966 AllianceGenome:MGI:2685195
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm349; mKIAA1993
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in olfactory epithelium and submandibular gland primordium. Orthologous to human ZBTB34 (zinc finger and BTB domain containing 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.1), CNS E18 (RPKM 4.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb34 in Genome Data Viewer
    Location:
    2 B; 2 22.44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (33296121..33321339, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (33406108..33431324, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Ral GEF with PH domain and SH3 binding motif 1 Neighboring gene predicted gene, 23546 Neighboring gene angiopoietin-like 2 Neighboring gene STARR-seq mESC enhancer starr_04235 Neighboring gene STARR-seq mESC enhancer starr_04237 Neighboring gene STARR-seq mESC enhancer starr_04239 Neighboring gene STARR-seq mESC enhancer starr_04240 Neighboring gene STARR-seq mESC enhancer starr_04241 Neighboring gene predicted gene 13536 Neighboring gene STARR-seq mESC enhancer starr_04242 Neighboring gene zinc finger and BTB domain containing 43 Neighboring gene predicted gene 13530

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PITX2c is expressed in the adult left atrium, and reducing Pitx2c expression promotes atrial fibrillation inducibility and complex changes in gene expression. Kirchhof P, et al. Circ Cardiovasc Genet, 2011 Apr. PMID 21282332
    2. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    3. A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. Gagliardi A, et al. EMBO J, 2013 Aug 14. PMID 23892456, Free PMC Article
    4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085507.2 → NP_001078976.1  zinc finger and BTB domain-containing protein 34 isoform 1

      See identical proteins and their annotated locations for NP_001078976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL928955
      Consensus CDS
      CCDS38106.1
      UniProtKB/TrEMBL
      A2ATY4, Q69Z45
      Related
      ENSMUSP00000108783.2, ENSMUST00000113158.8
      Conserved Domains (5) summary
      smart00355
      Location:390 → 412
      ZnF_C2H2; zinc finger
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18220
      Location:25 → 144
      BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
      pfam00096
      Location:446 → 467
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:404 → 429
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001276332.2 → NP_001263261.1  zinc finger and BTB domain-containing protein 34 isoform 2

      See identical proteins and their annotated locations for NP_001263261.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AL928955
      UniProtKB/TrEMBL
      Q69Z45
      Conserved Domains (5) summary
      smart00355
      Location:372 → 394
      ZnF_C2H2; zinc finger
      sd00017
      Location:374 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:428 → 449
      zf-C2H2; Zinc finger, C2H2 type
      cd18220
      Location:7 → 126
      BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
      pfam13465
      Location:386 → 411
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001411211.1 → NP_001398140.1  zinc finger and BTB domain-containing protein 34 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL928955
      UniProtKB/TrEMBL
      A2ATY4, Q69Z45
      Related
      ENSMUSP00000088560.3, ENSMUST00000091037.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      33296121..33321339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498041.5 → XP_006498104.1  zinc finger and BTB domain-containing protein 34 isoform X2

      See identical proteins and their annotated locations for XP_006498104.1

      UniProtKB/TrEMBL
      Q69Z45
      Conserved Domains (5) summary
      smart00355
      Location:372 → 394
      ZnF_C2H2; zinc finger
      sd00017
      Location:374 → 394
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:428 → 449
      zf-C2H2; Zinc finger, C2H2 type
      cd18220
      Location:7 → 126
      BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
      pfam13465
      Location:386 → 411
      zf-H2C2_2; Zinc-finger double domain

    2. XM_036161825.1 → XP_036017718.1  zinc finger and BTB domain-containing protein 34 isoform X1

      UniProtKB/TrEMBL
      A2ATY4, Q69Z45
      Conserved Domains (5) summary
      smart00355
      Location:390 → 412
      ZnF_C2H2; zinc finger
      sd00017
      Location:392 → 412
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18220
      Location:25 → 144
      BTB_POZ_ZBTB34; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34)
      pfam00096
      Location:446 → 467
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:404 → 429
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version

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