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    Snhg3 small nucleolar RNA host gene 3 [ Mus musculus (house mouse) ]

    Gene ID: 399101, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snhg3provided by MGI
    Official Full Name
    small nucleolar RNA host gene 3provided by MGI
    Primary source
    MGI:MGI:2684817
    See related
    Ensembl:ENSMUSG00000085241 AllianceGenome:MGI:2684817
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U17HG; Rnu17d
    Summary
    Is active in nucleus. Orthologous to human SNHG3 (small nucleolar RNA host gene 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver E14 (RPKM 60.1), liver E14.5 (RPKM 56.6) and 22 other tissues See more
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    Genomic context

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    See Snhg3 in Genome Data Viewer
    Location:
    4 D2.3; 4 65.23 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132079244..132080997, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132351933..132353686, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tRNA selenocysteine 1 associated protein 1 Neighboring gene CRISPRi-validated cis-regulatory element for Rcc1 and Trnau1ap Neighboring gene regulator of chromosome condensation 1 Neighboring gene CRISPRi-validated cis-regulatory element for Atpif1, Phactr4, Ptpru, Rcc1 and Snhg3 Neighboring gene small nucleolar RNA, H/ACA box 73b Neighboring gene small nucleolar RNA, H/ACA box 73a Neighboring gene phosphatase and actin regulator 4 Neighboring gene predicted gene, 23055

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. N6-methyladenosine demethylase ALKBH5 homologous protein protects against cerebral I/R injury though suppressing SNHG3-mediated neural PANoptosis: Involvement of m6A-related macromolecules in the diseases of nervous system. Qiu Y, et al. Int J Biol Macromol, 2024 Aug. PMID 38996894
    2. LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling. Xie X, et al. Elife, 2024 Oct 22. PMID 39436790, Free PMC Article
    3. The long non-coding RNA Snhg3 is essential for mouse embryonic stem cell self-renewal and pluripotency. Lu W, et al. Stem Cell Res Ther, 2019 May 31. PMID 31151411, Free PMC Article
    4. The host gene for intronic U17 small nucleolar RNAs in mammals has no protein-coding potential and is a member of the 5'-terminal oligopyrimidine gene family. Pelczar P, et al. Mol Cell Biol, 1998 Aug. PMID 9671460, Free PMC Article
    5. LncRNA SNHG3 promotes autophagy-induced neuronal cell apoptosis by acting as a ceRNA for miR-485 to up-regulate ATG7 expression. Cao Y, et al. Metab Brain Dis, 2020 Dec. PMID 32860611

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA Snhg3 aggravates hepatic steatosis via PPARgamma signaling.
      Title: LncRNA Snhg3 aggravates hepatic steatosis via PPARγ signaling.
    2. N6-methyladenosine demethylase ALKBH5 homologous protein protects against cerebral I/R injury though suppressing SNHG3-mediated neural PANoptosis: Involvement of m6A-related macromolecules in the diseases of nervous system.
      Title: N6-methyladenosine demethylase ALKBH5 homologous protein protects against cerebral I/R injury though suppressing SNHG3-mediated neural PANoptosis: Involvement of m6A-related macromolecules in the diseases of nervous system.
    3. LncRNA SNHG3 promotes autophagy-induced neuronal cell apoptosis by acting as a ceRNA for miR-485 to up-regulate ATG7 expression.
      Title: LncRNA SNHG3 promotes autophagy-induced neuronal cell apoptosis by acting as a ceRNA for miR-485 to up-regulate ATG7 expression.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Markers

    Potential readthrough

    Included gene: Rcc1

    Other Names

    • RNA, U17d small nucleolar
    • small nucleolar RNA host gene (non-protein coding) 3

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_003270.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK076188, CN834544
      Related
      ENSMUST00000152943.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132079244..132080997 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_002904.1: Suppressed sequence

      Description
      NR_002904.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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