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    Abcb8 ATP-binding cassette, sub-family B member 8 [ Mus musculus (house mouse) ]

    Gene ID: 74610, updated on 9-Dec-2024

    Summary

    Official Symbol
    Abcb8provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family B member 8provided by MGI
    Primary source
    MGI:MGI:1351667
    See related
    Ensembl:ENSMUSG00000028973 AllianceGenome:MGI:1351667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MITOSUR; 4833412N02Rik
    Summary
    Predicted to enable ABC-type peptide transporter activity and ATP binding activity. Predicted to be involved in cell volume homeostasis and mitochondrial potassium ion transmembrane transport. Located in mitochondrial inner membrane. Part of mitochondrial ATP-gated potassium channel complex. Is expressed in several structures, including alimentary system; nervous system; respiratory system; retina; and urinary system. Orthologous to human ABCB8 (ATP binding cassette subfamily B member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 40.2), heart adult (RPKM 32.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Abcb8 in Genome Data Viewer
    Location:
    5 A3; 5 11.57 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24598679..24617757)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24393681..24412759)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 15589 Neighboring gene potassium voltage-gated channel, subfamily H (eag-related), member 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:23853089-23853272 Neighboring gene STARR-positive B cell enhancer ABC_E10309 Neighboring gene nitric oxide synthase 3, endothelial cell Neighboring gene STARR-positive B cell enhancer ABC_E4747 Neighboring gene STARR-positive B cell enhancer ABC_E1677 Neighboring gene autophagy related 9B Neighboring gene cyclin dependent kinase 5 Neighboring gene STARR-positive B cell enhancer ABC_E9251 Neighboring gene acid-sensing ion channel 3 Neighboring gene solute carrier family 4 (anion exchanger), member 2 Neighboring gene predicted gene, 22333

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type transporter activity  
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATPase-coupled transmembrane transporter activity  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis  
    involved_in mitochondrial potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport  
    involved_in potassium ion transmembrane transport  
    involved_in transmembrane transport  
    Component Evidence Code Pubs
    is_active_in membrane  
    part_of mitochondrial ATP-gated potassium channel complex PubMed 
    part_of mitochondrial ATP-gated potassium channel complex  
    part_of mitochondrial ATP-gated potassium channel complex  
    located_in mitochondrial inner membrane PubMed 
    located_in mitochondrial inner membrane  
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    mitochondrial potassium channel ATP-binding subunit
    Names
    ATP-binding cassette sub-family B member 8, mitochondrial
    ATP-binding cassette, sub-family B (MDR/TAP), member 8
    mitochondrial sulfonylurea-receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029020.3NP_083296.2  mitochondrial potassium channel ATP-binding subunit precursor

      See identical proteins and their annotated locations for NP_083296.2

      Status: VALIDATED

      Source sequence(s)
      AC113055
      Consensus CDS
      CCDS19118.1
      UniProtKB/Swiss-Prot
      Q8C695, Q8C7W4, Q9CXJ4
      Related
      ENSMUSP00000072826.6, ENSMUST00000073076.12
      Conserved Domains (1) summary
      COG1132
      Location:116695
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      24598679..24617757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249790.3XP_011248092.1  mitochondrial potassium channel ATP-binding subunit isoform X2

      Conserved Domains (3) summary
      cd03249
      Location:184422
      ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
      cd07346
      Location:352
      ABC_6TM_exporters; TM helix 4 [structural motif]
      cl38913
      Location:1157
      ABC_6TM_exporters; Six-transmembrane helical domain of the ATP-binding cassette transporters
    2. XM_006535812.1XP_006535875.1  mitochondrial potassium channel ATP-binding subunit isoform X1

      See identical proteins and their annotated locations for XP_006535875.1

      UniProtKB/Swiss-Prot
      Q8C695, Q8C7W4, Q9CXJ4
      Related
      ENSMUSP00000110729.2, ENSMUST00000115077.8
      Conserved Domains (1) summary
      COG1132
      Location:116695
      MdlB; ABC-type multidrug transport system, ATPase and permease component [Defense mechanisms]
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