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    EBF1 EIN3-binding F box protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817087, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EBF1
    Official Full Name
    EIN3-binding F box protein 1
    Primary source
    TAIR:AT2G25490
    Locus tag
    AT2G25490
    See related
    Araport:AT2G25490
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EIN3-binding F box protein 1; F13B15.15; F13B15_15; FBL6
    Summary
    Encodes an F-box protein involved in the ubiquitin/proteasome-dependent proteolysis of EIN3.
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    Genomic context

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    See EBF1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    2
    Sequence:
    Chromosome: 2; NC_003071.7 (10847375..10850797, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene TPX2 (targeting protein for Xklp2) protein family Neighboring gene prolamin-like protein (DUF784) Neighboring gene Inosine triphosphate pyrophosphatase family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Light-Dependent Degradation of PIF3 by SCF(EBF1/2) Promotes a Photomorphogenic Response in Arabidopsis. Dong J, et al. Curr Biol, 2017 Aug 21. PMID 28736168, Free PMC Article
    2. The Arabidopsis EIN3 binding F-Box proteins EBF1 and EBF2 have distinct but overlapping roles in ethylene signaling. Binder BM, et al. Plant Cell, 2007 Feb. PMID 17307926, Free PMC Article
    3. Arabidopsis EIN3-binding F-box 1 and 2 form ubiquitin-protein ligases that repress ethylene action and promote growth by directing EIN3 degradation. Gagne JM, et al. Proc Natl Acad Sci U S A, 2004 Apr 27. PMID 15090654, Free PMC Article
    4. The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis. Hao D, et al. Proc Natl Acad Sci U S A, 2021 Feb 9. PMID 33526703, Free PMC Article
    5. The Red Light Receptor Phytochrome B Directly Enhances Substrate-E3 Ligase Interactions to Attenuate Ethylene Responses. Shi H, et al. Dev Cell, 2016 Dec 5. PMID 27889482, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis.
      Title: The RING E3 ligase SDIR1 destabilizes EBF1/EBF2 and modulates the ethylene response to ambient temperature fluctuations in Arabidopsis.
    2. In response to light activation of phytochrome photoreceptors, EIN3-BINDING F BOX PROTEINs (EBFs) 1 and 2 mediate PIF3 protein degradation in a manner dependent on light-induced phosphorylation of PIF3.
      Title: Light-Dependent Degradation of PIF3 by SCF(EBF1/2) Promotes a Photomorphogenic Response in Arabidopsis.
    3. The light-activated association of phyB, EIN3, and EBF1/EBF2 proteins stimulates robust EIN3 degradation by SCF(EBF1/EBF2) E3 ligases. We reveal that phyB manipulates substrate-E3 ligase interactions in a light-dependent manner, thus directly controlling the stability of EIN3.
      Title: The Red Light Receptor Phytochrome B Directly Enhances Substrate-E3 Ligase Interactions to Attenuate Ethylene Responses.
    4. Data show that through control of EIN3/EIL1 levels, EBF1 and EBF2 fine-tune ethylene responses by repressing signaling in the absence of hormone, dampening signaling at high concentrations, and promoting rapid recovery after ethylene levels dissipate.
      Title: The Arabidopsis EIN3 binding F-Box proteins EBF1 and EBF2 have distinct but overlapping roles in ethylene signaling.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_128106.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of ethylene-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to ethylene IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    EIN3-binding F box protein 1
    NP_565597.1
    • EIN3-binding F box protein 1 (EBF1); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), F-box domain, Skp2-like (InterPro:IPR022364), Leucine-rich repeat, cysteine-containing subtype (InterPro:IPR006553); BEST Arabidopsis thaliana protein match is: EIN3-binding F box protein 2 (TAIR:AT5G25350.1); Has 13069 Blast hits to 4728 proteins in 296 species: Archae - 0; Bacteria - 528; Metazoa - 5097; Fungi - 1628; Plants - 4199; Viruses - 9; Other Eukaryotes - 1608 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10847375..10850797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128106.4 → NP_565597.1  EIN3-binding F box protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565597.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHK7, Q0WM37, Q9SKK0
      UniProtKB/TrEMBL
      A0A178VLK5, A0A654EXI3
      Conserved Domains (3) summary
      cd09293
      Location:149 → 298
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:179 → 204
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:64 → 101
      F-box-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SKK0.1

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