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    CRY1 cryptochrome circadian regulator 1 [ Homo sapiens (human) ]

    Gene ID: 1407, updated on 4-Jan-2025

    Summary

    Official Symbol
    CRY1provided by HGNC
    Official Full Name
    cryptochrome circadian regulator 1provided by HGNC
    Primary source
    HGNC:HGNC:2384
    See related
    Ensembl:ENSG00000008405 MIM:601933; AllianceGenome:HGNC:2384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DSPD; PHLL1
    Summary
    This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Loss of the related gene in mouse results in a shortened circadian cycle in complete darkness. [provided by RefSeq, Jan 2014]
    Expression
    Broad expression in testis (RPKM 23.5), thyroid (RPKM 10.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See CRY1 in Genome Data Viewer
    Location:
    12q23.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (106991364..107093549, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (106954997..107057182, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (107385142..107487327, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6950 Neighboring gene transmembrane protein 263 Neighboring gene MPRA-validated peak1931 silencer Neighboring gene mitochondrial transcription termination factor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6951 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4821 Neighboring gene uncharacterized LOC124903009 Neighboring gene Sharpr-MPRA regulatory region 1195 Neighboring gene Sharpr-MPRA regulatory region 11431 Neighboring gene SET pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables DNA (6-4) photolyase activity PubMed 
    enables DNA binding  
    enables E-box binding  
    enables FAD binding  
    enables blue light photoreceptor activity PubMed 
    NOT enables deoxyribodipyrimidine photo-lyase activity PubMed 
    enables double-stranded DNA binding PubMed 
    enables histone deacetylase binding  
    enables nuclear receptor binding PubMed 
    enables phosphatase binding PubMed 
    enables protein binding PubMed 
    enables protein kinase binding  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in blue light signaling pathway PubMed 
    involved_in circadian regulation of gene expression  
    involved_in circadian regulation of gene expression  
    involved_in circadian rhythm  
    involved_in entrainment of circadian clock by photoperiod  
    involved_in entrainment of circadian clock by photoperiod  
    involved_in gluconeogenesis  
    involved_in glucose homeostasis  
    involved_in lipid storage  
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of DNA-templated transcription  
    involved_in negative regulation of G protein-coupled receptor signaling pathway  
    involved_in negative regulation of circadian rhythm  
    involved_in negative regulation of glucocorticoid receptor signaling pathway  
    involved_in negative regulation of glucocorticoid secretion  
    involved_in negative regulation of gluconeogenesis  
    involved_in negative regulation of protein ubiquitination  
    involved_in negative regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of gluconeogenesis  
    involved_in positive regulation of protein ubiquitination  
    involved_in regulation of DNA damage checkpoint  
    involved_in regulation of circadian rhythm  
    involved_in response to activity  
    involved_in response to glucagon  
    involved_in response to insulin  
    involved_in response to light stimulus  
    involved_in signal transduction in response to DNA damage  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in mitochondrion  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    cryptochrome-1
    Names
    cryptochrome 1 (photolyase-like)
    cryptochrome circadian clock 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413458.1 → NP_001400387.1  cryptochrome-1 isoform a

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    2. NM_001413459.1 → NP_001400388.1  cryptochrome-1 isoform b

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    3. NM_001413460.1 → NP_001400389.1  cryptochrome-1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    4. NM_001413461.1 → NP_001400390.1  cryptochrome-1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
      UniProtKB/Swiss-Prot
      Q16526
      UniProtKB/TrEMBL
      A2I2P0
    5. NM_001413462.1 → NP_001400391.1  cryptochrome-1 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
      UniProtKB/Swiss-Prot
      Q16526
      UniProtKB/TrEMBL
      A2I2P0
    6. NM_001413463.1 → NP_001400392.1  cryptochrome-1 isoform e

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    7. NM_001413464.1 → NP_001400393.1  cryptochrome-1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    8. NM_001413465.1 → NP_001400394.1  cryptochrome-1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    9. NM_001413466.1 → NP_001400395.1  cryptochrome-1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    10. NM_001413467.1 → NP_001400396.1  cryptochrome-1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    11. NM_001413468.1 → NP_001400397.1  cryptochrome-1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    12. NM_001413469.1 → NP_001400398.1  cryptochrome-1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    13. NM_001413470.1 → NP_001400399.1  cryptochrome-1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    14. NM_004075.5 → NP_004066.1  cryptochrome-1 isoform d

      See identical proteins and their annotated locations for NP_004066.1

      Status: REVIEWED

      Source sequence(s)
      AK290552, BC017466, BJ993835, DB454192
      Consensus CDS
      CCDS9112.1
      UniProtKB/Swiss-Prot
      Q16526
      UniProtKB/TrEMBL
      A2I2P0
      Related
      ENSP00000008527.5, ENST00000008527.10
      Conserved Domains (2) summary
      COG0415
      Location:6 → 491
      PhrB; Deoxyribodipyrimidine photolyase [Replication, recombination and repair]
      pfam03441
      Location:288 → 486
      FAD_binding_7; FAD binding domain of DNA photolyase

    RNA

    1. NR_182152.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929
    2. NR_182153.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC007541, AC078929

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      106991364..107093549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428319.1 → XP_047284275.1  cryptochrome-1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      106954997..107057182 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054371141.1 → XP_054227116.1  cryptochrome-1 isoform X1

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