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    VTI1B vesicle transport through interaction with t-SNAREs 1B [ Homo sapiens (human) ]

    Gene ID: 10490, updated on 4-Jan-2025

    Summary

    Official Symbol
    VTI1Bprovided by HGNC
    Official Full Name
    vesicle transport through interaction with t-SNAREs 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:17793
    See related
    Ensembl:ENSG00000100568 MIM:603207; AllianceGenome:HGNC:17793
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    VTI1; VTI2; VTI1L; v-SNARE; vti1-rp1; VTI1-LIKE
    Summary
    Enables SNARE binding activity and chloride channel inhibitor activity. Involved in regulation of protein localization to plasma membrane. Located in several cellular components, including endosome membrane; lysosomal membrane; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in fat (RPKM 68.1), kidney (RPKM 45.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See VTI1B in Genome Data Viewer
    Location:
    14q24.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (67647085..67674632, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (61854218..61881753, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (68113802..68141349, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene gephyrin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5860 Neighboring gene uncharacterized LOC124903331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5863 Neighboring gene Sharpr-MPRA regulatory region 4541 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5865 Neighboring gene high mobility group box 1 pseudogene 34 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5866 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:68161998-68162634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8584 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8585 Neighboring gene RNA, 5S ribosomal pseudogene 386 Neighboring gene cytochrome c oxidase subunit 7A2 pseudogene 1 Neighboring gene arginase 2 Neighboring gene RNA, 7SL, cytoplasmic 369, pseudogene Neighboring gene retinol dehydrogenase 11 Neighboring gene retinol dehydrogenase 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag co-localizes with the endosomal SNARE proteins Vti1b and syntaxin 8 in HPS2 fibroblasts PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNAP receptor activity  
    enables SNARE binding  
    enables SNARE binding PubMed 
    enables chloride channel inhibitor activity PubMed 
    enables protein binding PubMed 
    Component Evidence Code Pubs
    is_active_in ER to Golgi transport vesicle membrane  
    is_active_in Golgi apparatus  
    located_in Golgi apparatus PubMed 
    part_of SNARE complex  
    located_in cytosol  
    located_in early endosome membrane PubMed 
    is_active_in endoplasmic reticulum membrane  
    located_in extracellular region  
    located_in intracellular membrane-bounded organelle  
    is_active_in late endosome membrane  
    located_in late endosome membrane PubMed 
    located_in lysosomal membrane PubMed 
    located_in neuronal cell body  
    located_in perinuclear region of cytoplasm PubMed 
    located_in platelet alpha granule lumen  
    located_in presynaptic endosome membrane  
    located_in recycling endosome PubMed 
    located_in recycling endosome membrane PubMed 
    located_in synaptic vesicle  
    located_in vesicle PubMed 

    General protein information

    Preferred Names
    vesicle transport through interaction with t-SNAREs homolog 1B
    Names
    vesicle transport v-SNARE protein Vti1-like 1
    vesicle-associated soluble NSF attachment protein receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006370.3NP_006361.1  vesicle transport through interaction with t-SNAREs homolog 1B

      See identical proteins and their annotated locations for NP_006361.1

      Status: VALIDATED

      Source sequence(s)
      AL049779, BC003142
      Consensus CDS
      CCDS9786.1
      UniProtKB/Swiss-Prot
      O43547, Q96J28, Q9UEU0
      UniProtKB/TrEMBL
      A8K6M4, B2RE64, Q5TZX9
      Related
      ENSP00000450731.1, ENST00000554659.6
      Conserved Domains (2) summary
      cd15890
      Location:136197
      SNARE_Vti1b; SNARE motif of Vti1b-like
      pfam05008
      Location:1896
      V-SNARE; Vesicle transport v-SNARE protein N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      67647085..67674632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      61854218..61881753 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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