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    PGIP1 polygalacturonase inhibiting protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 830577, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PGIP1
    Official Full Name
    polygalacturonase inhibiting protein 1
    Primary source
    TAIR:AT5G06860
    Locus tag
    AT5G06860
    See related
    Araport:AT5G06860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPGIP1; MOJ9.3; MOJ9_3; polygalacturonase inhibiting protein 1; POLYGALACTURONASE INHIBITING PROTEIN 1
    Summary
    Encodes a polygalacturonase inhibiting protein involved in defense response. PGIPs inhibit the function of cell wall pectin degrading enzymes such as those produced by fungal pathogens. PGIP1 is induced by fungal infection. Suppressed in the proton sensitive stop1-mutant, but the transcription level was recovered by transformation of STOP2. Knockout mutant showed severe damage in the root tip in low Ca and low pH medium.
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    Genomic context

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    See PGIP1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    2
    Sequence:
    Chromosome: 5; NC_003076.8 (2132350..2133587)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene bZIP transcription factor family protein Neighboring gene C2 calcium/lipid-binding plant phosphoribosyltransferase family protein Neighboring gene ncRNA Neighboring gene polygalacturonase inhibiting protein 2 Neighboring gene Ubiquitin-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antisense expression of the Arabidopsis thaliana AtPGIP1 gene reduces polygalacturonase-inhibiting protein accumulation and enhances susceptibility to Botrytis cinerea. Ferrari S, et al. Mol Plant Microbe Interact, 2006 Aug. PMID 16903359
    2. Spatial distribution of polygalacturonase-inhibiting proteins in Arabidopsis and their expression induced by Stemphylium solani infection. Di CX, et al. Gene, 2012 Sep 10. PMID 22771916
    3. Tandemly duplicated Arabidopsis genes that encode polygalacturonase-inhibiting proteins are regulated coordinately by different signal transduction pathways in response to fungal infection. Ferrari S, et al. Plant Cell, 2003 Jan. PMID 12509524, Free PMC Article
    4. Proteomics of loosely bound cell wall proteins of Arabidopsis thaliana cell suspension cultures: a critical analysis. Borderies G, et al. Electrophoresis, 2003 Oct. PMID 14595688
    5. Profiling of the Receptor for Activated C Kinase 1a (RACK1a) interaction network in Arabidopsis thaliana. Guo J, et al. Biochem Biophys Res Commun, 2019 Dec 3. PMID 31606202

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the transcription level of AtPGIP1 and AtPGIP2 was both up-regulated in response to infection with Stemphylium solani which caused hypersensitive cell death, but the transcription level of AtPGIP2 was less induced than AtPGIP1
      Title: Spatial distribution of polygalacturonase-inhibiting proteins in Arabidopsis and their expression induced by Stemphylium solani infection.
    2. PGIP1 activity contributes to basal resistance to Botrytis cinerea and is suggested to play a role in Arabidopsis innate immunity.
      Title: Antisense expression of the Arabidopsis thaliana AtPGIP1 gene reduces polygalacturonase-inhibiting protein accumulation and enhances susceptibility to Botrytis cinerea.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_120769.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables polygalacturonase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within signal transduction IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 
    located_in plasmodesma HDA PubMed 
    located_in secretory vesicle HDA PubMed 

    General protein information

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    Preferred Names
    polygalacturonase inhibiting protein 1
    NP_196304.1
    • polygalacturonase inhibiting protein 1 (PGIP1); FUNCTIONS IN: polygalacturonase inhibitor activity; INVOLVED IN: signal transduction, defense response; LOCATED IN: cell wall, plant-type cell wall; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Leucine-rich repeat-containing N-terminal domain, type 2 (InterPro:IPR013210), Leucine-rich repeat (InterPro:IPR001611); BEST Arabidopsis thaliana protein match is: polygalacturonase inhibiting protein 2 (TAIR:AT5G06870.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      2132350..2133587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_120769.2 → NP_196304.1  polygalacturonase inhibiting protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_196304.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M5J9
      UniProtKB/TrEMBL
      A0A178UBN4, Q8L9Q0
      Conserved Domains (2) summary
      PLN00113
      Location:26 → 302
      PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
      sd00033
      Location:121 → 144
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M5J9.1

    Gene LinkOut

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