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    NRPB2 DNA-directed RNA polymerase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828259, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NRPB2
    Official Full Name
    DNA-directed RNA polymerase family protein
    Primary source
    TAIR:AT4G21710
    Locus tag
    AT4G21710
    See related
    Araport:AT4G21710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EMB1989; EMBRYO DEFECTIVE 1989; F17L22.170; F17L22_170; RPB2
    Summary
    Encodes the unique second-largest subunit of DNA-dependent RNA polymerase II; the ortholog of budding yeast RPB2 and a homolog of the E. coli RNA polymerase beta subunit.
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    Genomic context

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    See NRPB2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    25
    Sequence:
    Chromosome: 4; NC_003075.7 (11535404..11542405, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene DUF2921 family protein, putative (DUF2921) Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene defensin-like protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Organismal benefits of transcription speed control at gene boundaries. Leng X, et al. EMBO Rep, 2020 Apr 3. PMID 32103605, Free PMC Article
    2. Discovery of paralogous nuclear gene sequences coding for the second-largest subunit of RNA polymerase II (RPB2) and their phylogenetic utility in gentianales of the asterids. Oxelman B, et al. Mol Biol Evol, 2000 Aug. PMID 10908634
    3. Arabidopsis CPL4 is an essential C-terminal domain phosphatase that suppresses xenobiotic stress responses. Fukudome A, et al. Plant J, 2014 Oct. PMID 25041272
    4. The role of Mediator in small and long noncoding RNA production in Arabidopsis thaliana. Kim YJ, et al. EMBO J, 2011 Mar 2. PMID 21252857, Free PMC Article
    5. PRL1, an RNA-binding protein, positively regulates the accumulation of miRNAs and siRNAs in Arabidopsis. Zhang S, et al. PLoS Genet, 2014 Dec. PMID 25474114, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Organismal benefits of transcription speed control at gene boundaries.
      Title: Organismal benefits of transcription speed control at gene boundaries.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_118291.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed 5'-3' RNA polymerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables ribonucleoside binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II, core complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of RNA polymerase II, core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase family protein
    NP_193902.1
    • NRPB2; CONTAINS InterPro DOMAIN/s: DNA-directed RNA polymerase, subunit 2, domain 6 (InterPro:IPR007120), RNA polymerase Rpb2, domain 7 (InterPro:IPR007641), RNA polymerase, beta subunit, protrusion (InterPro:IPR007644), RNA polymerase Rpb2, domain 3 (InterPro:IPR007645), DNA-directed RNA polymerase, subunit 2 (InterPro:IPR015712), RNA polymerase Rpb2, domain 2 (InterPro:IPR007642), RNA polymerase Rpb2, domain 4 (InterPro:IPR007646), RNA polymerase, beta subunit, conserved site (InterPro:IPR007121), RNA polymerase Rpb2, domain 5 (InterPro:IPR007647); BEST Arabidopsis thaliana protein match is: nuclear RNA polymerase C2 (TAIR:AT5G45140.1); Has 37546 Blast hits to 27868 proteins in 9192 species: Archae - 496; Bacteria - 17572; Metazoa - 623; Fungi - 7193; Plants - 3397; Viruses - 232; Other Eukaryotes - 8033 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11535404..11542405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118291.4 → NP_193902.1  DNA-directed RNA polymerase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193902.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P38420, Q9SVS6
      UniProtKB/TrEMBL
      A0A178V2G7, A0A5S9XUI5
      Conserved Domains (1) summary
      PRK08565
      Location:27 → 1179
      PRK08565; DNA-directed RNA polymerase subunit B; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38420.2

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