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    TRIP-1 TGF-beta receptor interacting protein 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819236, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TRIP-1
    Official Full Name
    TGF-beta receptor interacting protein 1
    Primary source
    TAIR:AT2G46280
    Locus tag
    AT2G46280
    See related
    Araport:AT2G46280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T3F17.7; TGF-beta receptor interacting protein 1; TIF3I1; TRIP1
    Summary
    Encodes a homolog of mammalian TGF-beta receptor interacting protein. Co-immunoprecipitates with BRI1 and can be phosphorylated in vitro by BRI1 at specific sites (Thr-14, Thr-89, and either Thr-197 or Ser-198). May therefore be a cytoplasmic BRI1 substrate and involved in brassinosteroid regulated plant growth and development.The encoded protein has two DWD motifs. It can bind to DDB1a in Y2H assays, and DDB1b in co-IP assays, and may be involved in the formation of a CUL4-based E3 ubiquitin ligase
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    Genomic context

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    See TRIP-1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (19003158..19005732, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene BTB/POZ/Kelch-associated protein Neighboring gene G-box binding factor 3 Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Interaction of Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase with a homolog of mammalian TGF-beta receptor interacting protein. Ehsan H, et al. Plant J, 2005 Jul. PMID 15998311
    2. CDKB1;1 forms a functional complex with CYCA2;3 to suppress endocycle onset. Boudolf V, et al. Plant Physiol, 2009 Jul. PMID 19458112, Free PMC Article
    3. Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Lee JH, et al. Plant Cell, 2008 Jan. PMID 18223036, Free PMC Article
    4. Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana. Van Leene J, et al. Mol Syst Biol, 2010 Aug 10. PMID 20706207, Free PMC Article
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study suggests a role for TRIP-1 in the molecular mechanisms of brassinosteroid-regulated plant growth and development, possibly as a cytoplasmic substrate of the BRI1 receptor kinase.
      Title: Interaction of Arabidopsis BRASSINOSTEROID-INSENSITIVE 1 receptor kinase with a homolog of mammalian TGF-beta receptor interacting protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_130191.6
    NM_180119.3
    NM_201968.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    TGF-beta receptor interacting protein 1
    NP_182151.1
    • TGF-beta receptor interacting protein 1 (TRIP-1); FUNCTIONS IN: protein binding, nucleotide binding; INVOLVED IN: response to cadmium ion, response to salt stress; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: male gametophyte, guard cell, root, cultured cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT2G46290.1); Has 49007 Blast hits to 22277 proteins in 692 species: Archae - 72; Bacteria - 7331; Metazoa - 19078; Fungi - 11080; Plants - 5389; Viruses - 0; Other Eukaryotes - 6057 (source: NCBI BLink).
    NP_850450.1
    • TGF-beta receptor interacting protein 1 (TRIP-1); FUNCTIONS IN: protein binding, nucleotide binding; INVOLVED IN: response to cadmium ion, response to salt stress; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: male gametophyte, guard cell, root, cultured cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT2G46290.1); Has 49007 Blast hits to 22277 proteins in 692 species: Archae - 72; Bacteria - 7331; Metazoa - 19078; Fungi - 11080; Plants - 5389; Viruses - 0; Other Eukaryotes - 6057 (source: NCBI BLink).
    NP_973697.1
    • TGF-beta receptor interacting protein 1 (TRIP-1); FUNCTIONS IN: protein binding, nucleotide binding; INVOLVED IN: response to cadmium ion, response to salt stress; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: male gametophyte, guard cell, root, cultured cell, pollen tube; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT2G46290.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19003158..19005732 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180119.3 → NP_850450.1  TGF-beta receptor interacting protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850450.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82342, Q38884, Q94K09, Q9C5Z0
      UniProtKB/TrEMBL
      A0A178VXD1, A0A384L026, B9DGS3, Q0WVZ3
      Conserved Domains (2) summary
      cd00200
      Location:7 → 316
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:13 → 50
      7WD40; WD40 repeat [structural motif]

    2. NM_130191.6 → NP_182151.1  TGF-beta receptor interacting protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_182151.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82342, Q38884, Q94K09, Q9C5Z0
      UniProtKB/TrEMBL
      A0A178VXD1, A0A384L026, B9DGS3, Q0WVZ3
      Conserved Domains (2) summary
      cd00200
      Location:7 → 316
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:13 → 50
      7WD40; WD40 repeat [structural motif]

    3. NM_201968.1 → NP_973697.1  TGF-beta receptor interacting protein 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973697.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4II65
      Conserved Domains (3) summary
      COG2319
      Location:18 → 221
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:13 → 50
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:7 → 223
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38884.2

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