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    NOXY38 tetratricopeptide repeat (TPR)-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824378, updated on 18-Sep-2024

    Summary

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    Official Symbol
    NOXY38
    Official Full Name
    tetratricopeptide repeat (TPR)-containing protein
    Primary source
    TAIR:AT3G52140
    Locus tag
    AT3G52140
    See related
    Araport:AT3G52140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    FMT; FRIENDLY; FRIENDLY MITOCHONDRIA; non responding to oxylipins 38
    Summary
    Involved in regulating mitochondrial quality control. Regulates mitochondrial association time and thereby is involved in mitochondrial fusion. Mutants show unregulated autophagy and display transcriptomic markers of mitochondrial stress.
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    Genomic context

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    See NOXY38 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    29
    Sequence:
    Chromosome: 3; NC_003074.8 (19332828..19341739)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene SWAP (Suppressor-of-White-APricot)/surp domain-containing protein / D111/G-patch domain-containing protein Neighboring gene ncRNA Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene ncRNA Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene Phosphoglycerate mutase family protein Neighboring gene 3-ketoacyl-CoA synthase 15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FRIENDLY is required for efficient dark-induced mitophagy and controlled senescence in Arabidopsis. Kacprzak SM, et al. Free Radic Biol Med, 2023 Aug 1. PMID 37085125
    2. FMT, a protein that affects mitochondrial distribution, interacts with translation-related proteins in Arabidopsis thaliana. Ayabe H, et al. Plant Cell Rep, 2021 Feb. PMID 33385240
    3. FRIENDLY regulates mitochondrial distribution, fusion, and quality control in Arabidopsis. El Zawily AM, et al. Plant Physiol, 2014 Oct. PMID 25165398, Free PMC Article
    4. The genetic control of plant mitochondrial morphology and dynamics. Logan DC, et al. Plant J, 2003 Nov. PMID 14617080
    5. Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice. Ralevski A, et al. Cell Mol Life Sci, 2022 Jun 2. PMID 35652974, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FRIENDLY is required for efficient dark-induced mitophagy and controlled senescence in Arabidopsis.
      Title: FRIENDLY is required for efficient dark-induced mitophagy and controlled senescence in Arabidopsis.
    2. Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice.
      Title: Plant mitochondrial FMT and its mammalian homolog CLUH controls development and behavior in Arabidopsis and locomotion in mice.
    3. FMT, a protein that affects mitochondrial distribution, interacts with translation-related proteins in Arabidopsis thaliana.
      Title: FMT, a protein that affects mitochondrial distribution, interacts with translation-related proteins in Arabidopsis thaliana.
    4. Studies indicate taht the noxy38 mutation was mapped at the FRIENDLY MITOCHONDRIA (FMT) locus At3g52140.
      Title: Defense activated by 9-lipoxygenase-derived oxylipins requires specific mitochondrial proteins.
    5. Required for the correct cellular distribution of mitochondria.
      Title: The genetic control of plant mitochondrial morphology and dynamics.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_115073.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloroplast localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within intracellular distribution of mitochondria IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat (TPR)-containing protein
    NP_001190066.1
    • tetratricopeptide repeat (TPR)-containing protein; FUNCTIONS IN: binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT4G28080.1).
    NP_001190067.1
    • tetratricopeptide repeat (TPR)-containing protein; FUNCTIONS IN: binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT4G28080.1).
    NP_001190068.1
    • tetratricopeptide repeat (TPR)-containing protein; FUNCTIONS IN: binding; INVOLVED IN: biological_process unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT4G28080.1).
    NP_190782.3
    • tetratricopeptide repeat (TPR)-containing protein; FUNCTIONS IN: binding; INVOLVED IN: biological_process unknown; LOCATED IN: plasma membrane, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT1G01320.2); Has 11101 Blast hits to 3590 proteins in 410 species: Archae - 113; Bacteria - 3115; Metazoa - 4880; Fungi - 1415; Plants - 408; Viruses - 9; Other Eukaryotes - 1161 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      19332828..19341739
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203139.1 → NP_001190068.1  tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190068.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FF29, F4J5R9
      Conserved Domains (7) summary
      sd00006
      Location:1079 → 1114
      TPR; TPR repeat [structural motif]
      pfam05303
      Location:290 → 358
      DUF727; Protein of unknown function (DUF727)
      pfam12807
      Location:827 → 1009
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:411 → 681
      CLU; Clustered mitochondria
      pfam13374
      Location:1162 → 1203
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:1159 → 1234
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:126 → 203
      CLU_N; Mitochondrial function, CLU-N-term

    2. NM_001203138.1 → NP_001190067.1  tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190067.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FF29, F4J5S0
      Conserved Domains (7) summary
      sd00006
      Location:1056 → 1091
      TPR; TPR repeat [structural motif]
      pfam05303
      Location:290 → 358
      DUF727; Protein of unknown function (DUF727)
      pfam12807
      Location:827 → 986
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:411 → 681
      CLU; Clustered mitochondria
      pfam13374
      Location:1139 → 1180
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:1136 → 1211
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:126 → 203
      CLU_N; Mitochondrial function, CLU-N-term

    3. NM_001203137.1 → NP_001190066.1  tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190066.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4J5S1, F4J5S2, Q9SUZ1
      UniProtKB/TrEMBL
      A0A654FF29
      Conserved Domains (7) summary
      sd00006
      Location:1067 → 1102
      TPR; TPR repeat [structural motif]
      pfam05303
      Location:290 → 358
      DUF727; Protein of unknown function (DUF727)
      pfam12807
      Location:815 → 997
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:411 → 669
      CLU; Clustered mitochondria
      pfam13374
      Location:1150 → 1191
      TPR_10; Tetratricopeptide repeat
      pfam13424
      Location:1147 → 1222
      TPR_12; Tetratricopeptide repeat
      pfam15044
      Location:126 → 203
      CLU_N; Mitochondrial function, CLU-N-term

    4. NM_115073.5 → NP_190782.3  tetratricopeptide repeat (TPR)-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190782.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VKH1, A0A654FF29
      Conserved Domains (6) summary
      sd00006
      Location:1063 → 1098
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:1145 → 1219
      TPR_12; Tetratricopeptide repeat
      pfam05303
      Location:256 → 358
      DUF727; Protein of unknown function (DUF727)
      pfam12807
      Location:813 → 993
      eIF3_p135; Translation initiation factor eIF3 subunit 135
      pfam13236
      Location:411 → 669
      CLU; Clustered mitochondria
      pfam15044
      Location:128 → 203
      CLU_N; Mitochondrial function, CLU-N-term
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4J5S1.1

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