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    DiT1 dicarboxylate transporter 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831126, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DiT1
    Official Full Name
    dicarboxylate transporter 1
    Primary source
    TAIR:AT5G12860
    Locus tag
    AT5G12860
    See related
    Araport:AT5G12860
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    2-OXOGLUTARATE/MALATE TRANSLOCATOR; dicarboxylate transporter 1; T24H18.30; T24H18_30
    Summary
    AtpOMT1 encodes dicarboxylate transporter functions both as as an oxaloacetate/malate transporter and as a 2-oxoglutarate/malate transporter.
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    Genomic context

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    See DiT1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    3
    Sequence:
    Chromosome: 5; NC_003076.8 (4059579..4062289, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene calmodulin-domain protein kinase 7 Neighboring gene nuclear factor Y, subunit A1 Neighboring gene CCCH-type zinc finger protein with ARM repeat domain-containing protein Neighboring gene myb domain protein 46 Neighboring gene proline-rich family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The chloroplastic 2-oxoglutarate/malate transporter has dual function as the malate valve and in carbon/nitrogen metabolism. Kinoshita H, et al. Plant J, 2011 Jan. PMID 21175886
    2. Identifying and characterizing plastidic 2-oxoglutarate/malate and dicarboxylate transporters in Arabidopsis thaliana. Taniguchi M, et al. Plant Cell Physiol, 2002 Jul. PMID 12154133
    3. Nematode-induced changes of transporter gene expression in Arabidopsis roots. Hammes UZ, et al. Mol Plant Microbe Interact, 2005 Dec. PMID 16478044
    4. Proteomics of the chloroplast envelope membranes from Arabidopsis thaliana. Ferro M, et al. Mol Cell Proteomics, 2003 May. PMID 12766230
    5. The Arabidopsis Proteins AtNHR2A and AtNHR2B Are Multi-Functional Proteins Integrating Plant Immunity With Other Biological Processes. Singh R, et al. Front Plant Sci, 2020. PMID 32194606, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001125744.1
    NM_121289.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alpha-ketoglutarate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-ketoglutarate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables malate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxaloacetate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxaloacetate transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxoglutarate:malate antiporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in alpha-ketoglutarate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ammonia assimilation cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in malate transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in oxaloacetate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nematode HEP PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast thylakoid HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    dicarboxylate transporter 1
    NP_001119216.1
    • dicarboxylate transporter 1 (DiT1); FUNCTIONS IN: oxoglutarate:malate antiporter activity; INVOLVED IN: N-terminal protein myristoylation, malate transport, response to nematode; LOCATED IN: mitochondrion, chloroplast, plastid, membrane; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sodium/sulphate symporter (InterPro:IPR001898); BEST Arabidopsis thaliana protein match is: dicarboxylate transport 2.1 (TAIR:AT5G64290.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_568283.2
    • dicarboxylate transporter 1 (DiT1); FUNCTIONS IN: oxoglutarate:malate antiporter activity; INVOLVED IN: N-terminal protein myristoylation, malate transport, response to nematode; LOCATED IN: mitochondrion, chloroplast, plastid, membrane, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Sodium/sulphate symporter (InterPro:IPR001898); BEST Arabidopsis thaliana protein match is: dicarboxylate transport 2.1 (TAIR:AT5G64290.1); Has 6431 Blast hits to 6401 proteins in 1396 species: Archae - 84; Bacteria - 5538; Metazoa - 82; Fungi - 8; Plants - 142; Viruses - 1; Other Eukaryotes - 576 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      4059579..4062289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121289.4 → NP_568283.2  dicarboxylate transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_568283.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q93Y83, Q9LXV3
      UniProtKB/TrEMBL
      A0A178UA33, A0A5S9Y3L3
      Conserved Domains (1) summary
      TIGR00785
      Location:109 → 551
      dass; anion transporter

    2. NM_001125744.1 → NP_001119216.1  dicarboxylate transporter 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119216.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B3H4S6
      Conserved Domains (2) summary
      TIGR00785
      Location:109 → 551
      dass; anion transporter
      pfam00939
      Location:94 → 556
      Na_sulph_symp; Sodium:sulfate symporter transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LXV3.1

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