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    SAP130a Cleavage and polyadenylation specificity factor (CPSF) A subunit protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824686, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAP130a
    Official Full Name
    Cleavage and polyadenylation specificity factor (CPSF) A subunit protein
    Primary source
    TAIR:AT3G55200
    Locus tag
    AT3G55200
    See related
    Araport:AT3G55200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana spliceosome-associated protein 130 a; AtSAP130a; spliceosome-associated protein 130 a
    Summary
    Encodes a spliceosomal protein that is required for proper reproduction. RNAi lines display low pollen viability,caused by a defect in the transition from microspore to bicellular stage during pollen development.
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    Genomic context

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    See SAP130a in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (20460329..20465201)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene NAC domain containing protein 63 Neighboring gene Cleavage and polyadenylation specificity factor (CPSF) A subunit protein Neighboring gene Disease resistance-responsive (dirigent-like protein) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AtSAP130/AtSF3b-3 function is required for reproduction in Arabidopsis thaliana. Aki S, et al. Plant Cell Physiol, 2011 Aug. PMID 21680607
    2. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475
    3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtSAP130a and AtSAP130b play an indispensable role in specific spatiotemporal events in reproduction.[AtSAp130a]
      Title: AtSAP130/AtSF3b-3 function is required for reproduction in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001339727.1
    NM_001339728.1

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    involved_in microgametogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plant ovule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plant ovule development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pollen germination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Cleavage and polyadenylation specificity factor (CPSF) A subunit protein
    NP_001319757.1
    • Cleavage and polyadenylation specificity factor (CPSF) A subunit protein; FUNCTIONS IN: nucleic acid binding; INVOLVED IN: biological_process unknown; LOCATED IN: nucleus, chloroplast; EXPRESSED IN: guard cell; CONTAINS InterPro DOMAIN/s: WD40 repeat (InterPro:IPR001680), Cleavage/polyadenylation specificity factor, A subunit, C-terminal (InterPro:IPR004871); BEST Arabidopsis thaliana protein match is: Cleavage and polyadenylation specificity factor (CPSF) A subunit protein (TAIR:AT3G55220.1); Has 1074 Blast hits to 953 proteins in 223 species: Archae - 0; Bacteria - 2; Metazoa - 406; Fungi - 248; Plants - 228; Viruses - 0; Other Eukaryotes - 190 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20460329..20465201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115378.4 → NP_567015.1  Cleavage and polyadenylation specificity factor (CPSF) A subunit protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567015.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0DKL4, P0DKL6, Q570A5, Q9LD60
      UniProtKB/TrEMBL
      A0A178VN71, A0A5S9XL36, A0A654FFY1
      Conserved Domains (3) summary
      pfam03178
      Location:861 → 1180
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:75 → 589
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
      cl29593
      Location:581 → 651
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. NM_001339727.1 → NP_001319757.1  Cleavage and polyadenylation specificity factor (CPSF) A subunit protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0DKL4, P0DKL6, Q570A5, Q9LD60
      UniProtKB/TrEMBL
      A0A178VN71, A0A5S9XL36, A0A654FFY1
      Conserved Domains (3) summary
      pfam03178
      Location:861 → 1180
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:75 → 589
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
      cl29593
      Location:581 → 651
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. NM_001339728.1 → NP_001327611.1  Cleavage and polyadenylation specificity factor (CPSF) A subunit protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P0DKL4, P0DKL6, Q570A5, Q9LD60
      UniProtKB/TrEMBL
      A0A178VN71, A0A5S9XL36, A0A654FFY1
      Conserved Domains (3) summary
      pfam03178
      Location:861 → 1180
      CPSF_A; CPSF A subunit region
      pfam10433
      Location:75 → 589
      MMS1_N; Mono-functional DNA-alkylating methyl methanesulfonate N-term
      cl29593
      Location:581 → 651
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0DKL4.1
    P0DKL6.1

    Gene LinkOut

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