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    URH1 uridine-ribohydrolase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818204, updated on 18-Sep-2024

    Summary

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    Official Symbol
    URH1
    Official Full Name
    uridine-ribohydrolase 1
    Primary source
    TAIR:AT2G36310
    Locus tag
    AT2G36310
    See related
    Araport:AT2G36310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2H17.8; F2H17_8; NSH1; nucleoside hydrolase 1; uridine-ribohydrolase 1
    Summary
    Encodes a cytoplasmic nucleoside hydrolase. It has the highest levels of activity with uridine followed by xanthosine. It shows little activity with inosine and none with cytidine. Mutant analyses indicate that it plays a role in purine and pyrimidine catabolism.
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    Genomic context

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    See URH1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (15224497..15227276, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene farnesylated protein-converting enzyme 2 Neighboring gene ncRNA Neighboring gene A20/AN1-like zinc finger family protein Neighboring gene GDSL-like Lipase/Acylhydrolase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AMP and GMP Catabolism in Arabidopsis Converge on Xanthosine, Which Is Degraded by a Nucleoside Hydrolase Heterocomplex. Baccolini C, et al. Plant Cell, 2019 Mar. PMID 30787180, Free PMC Article
    2. Arabidopsis thaliana nucleosidase mutants provide new insights into nucleoside degradation. Riegler H, et al. New Phytol, 2011 Jul. PMID 21599668, Free PMC Article
    3. Uridine-ribohydrolase is a key regulator in the uridine degradation pathway of Arabidopsis. Jung B, et al. Plant Cell, 2009 Mar. PMID 19293370, Free PMC Article
    4. Arabidopsis nucleoside hydrolases involved in intracellular and extracellular degradation of purines. Jung B, et al. Plant J, 2011 Mar. PMID 21235647
    5. Pyrimidine catabolism is required to prevent the accumulation of 5-methyluridine in RNA. Gao S, et al. Nucleic Acids Res, 2023 Aug 11. PMID 37334828, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NSH1 activates NSH2 in vitro and in vivo, forming a complex with almost two orders of magnitude higher catalytic efficiency for xanthosine hydrolysis than observed for NSH1 alone. Remarkably, an inactive NSH1 point mutant can activate NSH2 in vivo, fully preventing purine nucleoside accumulation in nsh1 background.
      Title: AMP and GMP Catabolism in Arabidopsis Converge on Xanthosine, Which Is Degraded by a Nucleoside Hydrolase Heterocomplex.
    2. Both URH1 and URH2 are required for efficient inosine and xanthosine hydrolytic activity.
      Title: Arabidopsis thaliana nucleosidase mutants provide new insights into nucleoside degradation.
    3. Results describe the cloning of and characterization of Arabidopsis thaliana, Uridine-Ribohydrolase 1.
      Title: Uridine-ribohydrolase is a key regulator in the uridine degradation pathway of Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_129188.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables adenosine nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables inosine nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine nucleosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables xanthosine nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within purine nucleoside catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within uridine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uridine-ribohydrolase 1
    NP_565843.1
    • uridine-ribohydrolase 1 (URH1); CONTAINS InterPro DOMAIN/s: Inosine/uridine-preferring nucleoside hydrolase (InterPro:IPR001910); BEST Arabidopsis thaliana protein match is: uridine-ribohydrolase 2 (TAIR:AT1G05620.1); Has 6361 Blast hits to 6297 proteins in 1364 species: Archae - 75; Bacteria - 4675; Metazoa - 179; Fungi - 233; Plants - 187; Viruses - 0; Other Eukaryotes - 1012 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15224497..15227276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129188.4 → NP_565843.1  uridine-ribohydrolase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565843.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q940Q6, Q9SJM7
      UniProtKB/TrEMBL
      A0A178VWR4, A0A5S9X4F7, A0A654F0S1
      Conserved Domains (1) summary
      PLN02717
      Location:22 → 336
      PLN02717; uridine nucleosidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SJM7.2

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