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    Tic20-I translocon at the inner envelope membrane of chloroplasts 20 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839374, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Tic20-I
    Official Full Name
    translocon at the inner envelope membrane of chloroplasts 20
    Primary source
    TAIR:AT1G04940
    Locus tag
    AT1G04940
    See related
    Araport:AT1G04940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    atTIC20; AtTic20-I; F13M7.7; F13M7_7; TIC20; translocon at the inner envelope membrane of chloroplasts 20; translocon at the inner envelope membrane of chloroplasts 20-I
    Summary
    Tic20 is believed to function as a component of the protein-conducting channel at the inner envelope membrane. Genes AT1G04940 and AT1G04945 were switched for the TAIR7 genome release to give consistency with MIPs annotation. The Arabidopsis genome encodes four Tic20 homologous proteins, AT1G04940(Tic20-I), AT2G47840(Tic20-II), AT4G03320(Tic20-IV) and AT5G55710(Tic20-V).
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    Genomic context

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    See Tic20-I in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    3
    Sequence:
    Chromosome: 1; NC_003070.9 (1399182..1400830)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene sucrose phosphate synthase 3F Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene HIT-type Zinc finger family protein Neighboring gene TATA BOX ASSOCIATED FACTOR II 59 Neighboring gene golgin family A protein (DUF1664)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Folding and self-association of atTic20 in lipid membranes: implications for understanding protein transport across the inner envelope membrane of chloroplasts. Campbell JH, et al. BMC Biochem, 2014 Dec 31. PMID 25551276, Free PMC Article
    2. Molecular and genetic analyses of Tic20 homologues in Arabidopsis thaliana chloroplasts. Kasmati AR, et al. Plant J, 2011 Jun. PMID 21395885
    3. Tic20 forms a channel independent of Tic110 in chloroplasts. Kovács-Bogdán E, et al. BMC Plant Biol, 2011 Sep 30. PMID 21961525, Free PMC Article
    4. In vivo studies on the roles of two closely related Arabidopsis Tic20 proteins, AtTic20-I and AtTic20-IV. Hirabayashi Y, et al. Plant Cell Physiol, 2011 Mar. PMID 21266460
    5. Uncovering the protein translocon at the chloroplast inner envelope membrane. Kikuchi S, et al. Science, 2013 Feb 1. PMID 23372012

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. atTic20 functions similarly to other small alpha-helical integral membrane proteins, such as Tim23, that are involved in protein transport across membranes.
      Title: Folding and self-association of atTic20 in lipid membranes: implications for understanding protein transport across the inner envelope membrane of chloroplasts.
    2. Tic20 protein is much less abundant than Tic110 in envelope membranes. Tic20 forms high molecular weight complexes separately from Tic110.
      Title: Tic20 forms a channel independent of Tic110 in chloroplasts.
    3. The inner envelope localized Tic20 proteins expose their C-termini to the chloroplast stroma.
      Title: The localization of Tic20 proteins in Arabidopsis thaliana is not restricted to the inner envelope membrane of chloroplasts.
    4. AtTic20-IV is expressed mainly in roots whereas AtTic20-I is more abundant in shoots than in roots.
      Title: In vivo studies on the roles of two closely related Arabidopsis Tic20 proteins, AtTic20-I and AtTic20-IV.
    5. The tic20-I mutants exhibit albinism and severe defects in chloroplast biogenesis.
      Title: Molecular and genetic analyses of Tic20 homologues in Arabidopsis thaliana chloroplasts.
    Submit: New GeneRIF Correction

    General gene information

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    NM_100372.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within protein import into chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into chloroplast stroma IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular anatomical structure IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translocon at the inner envelope membrane of chloroplasts 20
    NP_171986.3
    • translocon at the inner envelope membrane of chloroplasts 20 (TIC20); CONTAINS InterPro DOMAIN/s: Uncharacterised conserved protein ycf60 (InterPro:IPR019109), Chloroplast protein import component Tic20 (InterPro:IPR005691); BEST Arabidopsis thaliana protein match is: HIT-type Zinc finger family protein (TAIR:AT1G04945.3); Has 279 Blast hits to 278 proteins in 76 species: Archae - 0; Bacteria - 100; Metazoa - 0; Fungi - 0; Plants - 114; Viruses - 0; Other Eukaryotes - 65 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      1399182..1400830
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100372.5 → NP_171986.3  translocon at the inner envelope membrane of chloroplasts 20 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171986.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GZ79, Q9MAU2
      UniProtKB/TrEMBL
      A0A178W3W6, A0A654E6U2
      Conserved Domains (1) summary
      cl15935
      Location:59 → 274
      TIC20; Chloroplast import apparatus Tic20-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GZ79.1

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