BZR1 Brassinosteroid signaling positive regulator (BZR1) family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BZR1
Official Full Name: Brassinosteroid signaling positive regulator (BZR1) family protein
Primary source: TAIR:AT1G75080
Locus tag: AT1G75080
See related: Araport:AT1G75080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BRASSINAZOLE-RESISTANT 1; F9E10.7; F9E10_7
Summary: Encodes a positive regulator of the brassinosteroid (BR) signalling pathway that mediates both downstream BR responses and negative feedback regulation of BR biosynthesis. There is evidence for phosphorylation-dependent nucleocytoplasmic shuttling of BZR1. GSK3-like kinases (including BIN2), 14-3-3 proteins, and the phosphatase BSU1 seem to participate in this process. Phosphorylation also appears to affect BZR1's transcriptional activities.
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Genomic context

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See BZR1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 3

Sequence:: Chromosome: 1; NC_003070.9 (28185504..28188075)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Brassinosteroid regulates stomatal development in etiolated Arabidopsis cotyledons via transcription factors BZR1 and BES1.
Title: Brassinosteroid regulates stomatal development in etiolated Arabidopsis cotyledons via transcription factors BZR1 and BES1.
Comparative analysis of BZR1/BES1 family transcription factors in Arabidopsis.
Title: Comparative analysis of BZR1/BES1 family transcription factors in Arabidopsis.
Vacuolar H[+]-ATPase and BZR1 form a feedback loop to regulate the homeostasis of BR signaling in Arabidopsis.
Title: Vacuolar H(+)-ATPase and BZR1 form a feedback loop to regulate the homeostasis of BR signaling in Arabidopsis.
The BZR1-EDS1 module regulates plant growth-defense coordination.
Title: The BZR1-EDS1 module regulates plant growth-defense coordination.
Highlighting the potential utility of MBP crystallization chaperone for Arabidopsis BIL1/BZR1 transcription factor-DNA complex.
Title: Highlighting the potential utility of MBP crystallization chaperone for Arabidopsis BIL1/BZR1 transcription factor-DNA complex.
Nucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT1 in Arabidopsis thaliana.
Title: Nucleocytoplasmic trafficking and turnover mechanisms of BRASSINAZOLE RESISTANT1 in Arabidopsis thaliana.
BZR1 Physically Interacts with SPL9 to Regulate the Vegetative Phase Change and Cell Elongation in Arabidopsis.
Title: BZR1 Physically Interacts with SPL9 to Regulate the Vegetative Phase Change and Cell Elongation in Arabidopsis.
Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1.
Title: Sugar inhibits brassinosteroid signaling by enhancing BIN2 phosphorylation of BZR1.
SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth.
Title: SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth.
BES1/BZR1 Homolog 3 cooperates with E3 ligase AtRZF1 to regulate osmotic stress and brassinosteroid responses in Arabidopsis.
Title: BES1/BZR1 Homolog 3 cooperates with E3 ligase AtRZF1 to regulate osmotic stress and brassinosteroid responses in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_106164.3

Supported by ESTs:

NM_202416.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables cis-regulatory region sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brassinosteroid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within plant ovule development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Brassinosteroid signaling positive regulator (BZR1) family protein

NP_565099.1

BRASSINAZOLE-RESISTANT 1 (BZR1); CONTAINS InterPro DOMAIN/s: BZR1, transcriptional repressor (InterPro:IPR008540); BEST Arabidopsis thaliana protein match is: Brassinosteroid signalling positive regulator (BZR1) family protein (TAIR:AT1G19350.3); Has 2999 Blast hits to 628 proteins in 98 species: Archae - 0; Bacteria - 16; Metazoa - 199; Fungi - 166; Plants - 281; Viruses - 0; Other Eukaryotes - 2337 (source: NCBI BLink).

NP_974145.1

BRASSINAZOLE-RESISTANT 1 (BZR1); CONTAINS InterPro DOMAIN/s: BZR1, transcriptional repressor (InterPro:IPR008540); BEST Arabidopsis thaliana protein match is: Brassinosteroid signalling positive regulator (BZR1) family protein (TAIR:AT1G19350.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

28185504..28188075

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_202416.1 → NP_974145.1 Brassinosteroid signaling positive regulator (BZR1) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974145.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8S307, Q8VZD2, Q9C9Q2

UniProtKB/TrEMBL

A0A178WJU2, A0A5S9WUH8

Conserved Domains (1) summary

pfam05687
Location:22 → 129

BES1_N; BES1/BZR1 plant transcription factor, N-terminal
NM_106164.3 → NP_565099.1 Brassinosteroid signaling positive regulator (BZR1) family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565099.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8S307, Q8VZD2, Q9C9Q2

UniProtKB/TrEMBL

A0A178WJU2, A0A5S9WUH8

Conserved Domains (1) summary

pfam05687
Location:22 → 129

BES1_N; BES1/BZR1 plant transcription factor, N-terminal