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    MAG2 RINT-1 / TIP-1 family [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823924, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MAG2
    Official Full Name
    RINT-1 / TIP-1 family
    Primary source
    TAIR:AT3G47700
    Locus tag
    AT3G47700
    See related
    Araport:AT3G47700
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    maigo2
    Summary
    Involved in transportation of seed storage proteins from the ER to the vacuole. Mutant seed cell accumulates the precursors of 12S globulin and 2S albumin instead of the vacuolar-located mature proteins.
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    Genomic context

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    See MAG2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (17583601..17586707, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ternary complex factor MIP1 leucine-zipper protein Neighboring gene DNA binding protein Neighboring gene microtubule end binding protein EB1A Neighboring gene BANQUO 3 Neighboring gene uncharacterized protein Neighboring gene ATP-binding cassette A2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana. Li L, et al. Plant Cell, 2006 Dec. PMID 17194767, Free PMC Article
    2. Misregulation of ER-Golgi Vesicle Transport Induces ER Stress and Affects Seed Vigor and Stress Response. Zhao X, et al. Front Plant Sci, 2018. PMID 29868102, Free PMC Article
    3. MAIGO2 is involved in abscisic acid-mediated response to abiotic stresses and Golgi-to-ER retrograde transport. Zhao P, et al. Physiol Plant, 2013 Jun. PMID 23025793
    4. MAG2 and three MAG2-INTERACTING PROTEINs form an ER-localized complex to facilitate storage protein transport in Arabidopsis thaliana. Li L, et al. Plant J, 2013 Dec. PMID 24118572
    5. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAG2 and the three MIP proteins (MIP1, MIP2, MIP3) form a unique complex on the ER that is responsible for efficient transport of seed storage proteins.
      Title: MAG2 and three MAG2-INTERACTING PROTEINs form an ER-localized complex to facilitate storage protein transport in Arabidopsis thaliana.
    2. MAG2 functions as a complex with ZW10, and is potentially involved in Golgi-to-ER retrograde trafficking.
      Title: MAIGO2 is involved in abscisic acid-mediated response to abiotic stresses and Golgi-to-ER retrograde transport.
    3. These findings suggest that MAG2 functions in the transport of storage protein precursors between the endoplasmic reticulum and Golgi complex in plants. [MAG2]
      Title: MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_114638.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Dsl1/NZR complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RINT-1 / TIP-1 family
    NP_190354.1
    • maigo2 (MAG2); CONTAINS InterPro DOMAIN/s: RINT-1/TIP-1 (InterPro:IPR007528); BEST Arabidopsis thaliana protein match is: RINT-1 / TIP-1 family (TAIR:AT1G08400.1); Has 297 Blast hits to 297 proteins in 143 species: Archae - 16; Bacteria - 48; Metazoa - 107; Fungi - 71; Plants - 47; Viruses - 0; Other Eukaryotes - 8 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17583601..17586707 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114638.3 → NP_190354.1  RINT-1 / TIP-1 family [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190354.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RWD1, Q9STU3
      UniProtKB/TrEMBL
      A0A5S9XIQ1, A0A654FDS1
      Conserved Domains (1) summary
      pfam04437
      Location:299 → 788
      RINT1_TIP1; RINT-1 / TIP-1 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9STU3.1

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