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    LPD1 lipoamide dehydrogenase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820951, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LPD1
    Official Full Name
    lipoamide dehydrogenase 1
    Primary source
    TAIR:AT3G16950
    Locus tag
    AT3G16950
    See related
    Araport:AT3G16950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    LIPOAMIDE DEHYDROGENASE; lipoamide dehydrogenase 1; ptlpd1
    Summary
    encodes a plastid lipoamide dehydrogenase, subunit of the pyruvate dehydrogenase complex which provides acetyl-CoA for de novo fatty acid biosynthesis. The gene is highly expressed in developing seeds.
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    Genomic context

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    See LPD1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    15
    Sequence:
    Chromosome: 3; NC_003074.8 (5786298..5790536, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene miscRNA Neighboring gene calmodulin-binding transcription activator Neighboring gene plant self-incompatibility protein S1 family protein Neighboring gene Plant self-incompatibility protein S1 family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of ptLPD1 or ptLPD2, genes that encode isoforms of the plastidial lipoamide dehydrogenase, confers arsenate hypersensitivity in Arabidopsis. Chen W, et al. Plant Physiol, 2010 Jul. PMID 20488895, Free PMC Article
    2. Molecular evidence of a unique lipoamide dehydrogenase in plastids: analysis of plastidic lipoamide dehydrogenase from Arabidopsis thaliana. Lutziger I, et al. FEBS Lett, 2000 Oct 27. PMID 11056213
    3. Proteomic analysis of the Arabidopsis nucleolus suggests novel nucleolar functions. Pendle AF, et al. Mol Biol Cell, 2005 Jan. PMID 15496452, Free PMC Article
    4. Proteomic study of the Arabidopsis thaliana chloroplastic envelope membrane utilizing alternatives to traditional two-dimensional electrophoresis. Froehlich JE, et al. J Proteome Res, 2003 Jul-Aug. PMID 12938931
    5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These findings show that the ptLPD isoforms are critical in vivo determinants of arsenite-mediated arsenic sensitivity in Arabidopsis and possible strategic targets for increasing arsenic tolerance.
      Title: Disruption of ptLPD1 or ptLPD2, genes that encode isoforms of the plastidial lipoamide dehydrogenase, confers arsenate hypersensitivity in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001084696.1
    NM_112571.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables dihydrolipoyl dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within acetyl-CoA biosynthetic process from pyruvate TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in response to arsenic-containing substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 

    General protein information

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    Preferred Names
    lipoamide dehydrogenase 1
    NP_001078165.1
    • lipoamide dehydrogenase 1 (LPD1); CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Mercuric reductase (InterPro:IPR000815), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: dihydrolipoyl dehydrogenases (TAIR:AT4G16155.1); Has 30222 Blast hits to 30191 proteins in 3051 species: Archae - 599; Bacteria - 20783; Metazoa - 811; Fungi - 386; Plants - 503; Viruses - 0; Other Eukaryotes - 7140 (source: NCBI BLink).
    NP_566562.1
    • lipoamide dehydrogenase 1 (LPD1); FUNCTIONS IN: dihydrolipoyl dehydrogenase activity; INVOLVED IN: acetyl-CoA biosynthetic process from pyruvate; LOCATED IN: nucleolus, chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: FAD-dependent pyridine nucleotide-disulphide oxidoreductase (InterPro:IPR013027), Pyridine nucleotide-disulphide oxidoreductase, class I, active site (InterPro:IPR012999), Pyridine nucleotide-disulphide oxidoreductase, dimerisation (InterPro:IPR004099), Dihydrolipoamide dehydrogenase (InterPro:IPR006258), FAD/NAD-linked reductase, dimerisation (InterPro:IPR016156), Mercuric reductase (InterPro:IPR000815), Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region (InterPro:IPR001327); BEST Arabidopsis thaliana protein match is: dihydrolipoyl dehydrogenases (TAIR:AT4G16155.1); Has 30163 Blast hits to 30131 proteins in 3024 species: Archae - 612; Bacteria - 20708; Metazoa - 800; Fungi - 396; Plants - 503; Viruses - 0; Other Eukaryotes - 7144 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      5786298..5790536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112571.3 → NP_566562.1  lipoamide dehydrogenase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566562.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VGZ6, A0A5S9XED1
      Conserved Domains (1) summary
      PRK06416
      Location:103 → 553
      PRK06416; dihydrolipoamide dehydrogenase; Reviewed

    2. NM_001084696.1 → NP_001078165.1  lipoamide dehydrogenase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8MS68, B9DG34, Q9M5K5
      UniProtKB/TrEMBL
      A0A5S9XED1, A0A654F7Y2
      Conserved Domains (1) summary
      PRK06416
      Location:103 → 553
      PRK06416; dihydrolipoamide dehydrogenase; Reviewed
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8MS68.1

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