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    CRK6 cysteine-rich RLK (RECEPTOR-like protein kinase) 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828413, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CRK6
    Official Full Name
    cysteine-rich RLK (RECEPTOR-like protein kinase) 6
    Primary source
    TAIR:AT4G23140
    Locus tag
    AT4G23140
    See related
    Araport:AT4G23140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    cysteine-rich RLK (RECEPTOR-like protein kinase) 6; F7H19.330; F7H19_330; RECEPTOR-LIKE PROTEIN KINASE
    Summary
    Arabidopsis thaliana receptor-like protein kinase. Naming convention from Chen et al 2003 (PMID 14756307)
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    Genomic context

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    See CRK6 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (12121369..12124564)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Bromo-adjacent homology (BAH) domain-containing protein Neighboring gene cysteine-rich RLK (RECEPTOR-like protein kinase) 5 Neighboring gene cysteine-rich RLK (RECEPTOR-like protein kinase) 7 Neighboring gene cysteine-rich RECEPTOR-like kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Arabidopsis thaliana cysteine-rich receptor-like kinases CRK6 and CRK7 protect against apoplastic oxidative stress. Idänheimo N, et al. Biochem Biophys Res Commun, 2014 Mar 7. PMID 24530916
    2. Interaction of a protein phosphatase with an Arabidopsis serine-threonine receptor kinase. Stone JM, et al. Science, 1994 Nov 4. PMID 7973632
    3. Enhanced Arabidopsis pattern-triggered immunity by overexpression of cysteine-rich receptor-like kinases. Yeh YH, et al. Front Plant Sci, 2015. PMID 26029224, Free PMC Article
    4. Interaction of the maize and Arabidopsis kinase interaction domains with a subset of receptor-like protein kinases: implications for transmembrane signaling in plants. Braun DM, et al. Plant J, 1997 Jul. PMID 9263453
    5. Specific targeting of a plasmodesmal protein affecting cell-to-cell communication. Thomas CL, et al. PLoS Biol, 2008 Jan. PMID 18215111, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRK6 and CRK7 are active protein kinases with differential preference for divalent cations. O3 sensitivity of crk6 and crk7 is disguised by redundancy effect.
      Title: The Arabidopsis thaliana cysteine-rich receptor-like kinases CRK6 and CRK7 protect against apoplastic oxidative stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118443.3
    NM_179095.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to reactive oxygen species IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cysteine-rich RLK (RECEPTOR-like protein kinase) 6
    NP_567678.1
    • cysteine-rich RLK (RECEPTOR-like protein kinase) 6 (CRK6); FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Protein of unknown function DUF26 (InterPro:IPR002902), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: cysteine-rich RLK (RECEPTOR-like protein kinase) 8 (TAIR:AT4G23160.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_849426.1
    • cysteine-rich RLK (RECEPTOR-like protein kinase) 6 (CRK6); FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: plasma membrane; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Protein kinase, catalytic domain (InterPro:IPR000719), Protein of unknown function DUF26 (InterPro:IPR002902), Serine-threonine/tyrosine-protein kinase (InterPro:IPR001245), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: cysteine-rich RLK (RECEPTOR-like protein kinase) 8 (TAIR:AT4G23160.1); Has 119608 Blast hits to 118061 proteins in 4543 species: Archae - 108; Bacteria - 13357; Metazoa - 44377; Fungi - 10093; Plants - 34036; Viruses - 376; Other Eukaryotes - 17261 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      12121369..12124564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118443.3 → NP_567678.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567678.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65466, Q8GX18, Q9C5S9
      UniProtKB/TrEMBL
      A0A654FRY8
      Conserved Domains (3) summary
      smart00219
      Location:356 → 613
      TyrKc; Tyrosine kinase, catalytic domain
      cd14066
      Location:357 → 623
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam01657
      Location:33 → 128
      Stress-antifung; Salt stress response/antifungal

    2. NM_179095.1 → NP_849426.1  cysteine-rich RLK (RECEPTOR-like protein kinase) 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A654FRY8
      Conserved Domains (3) summary
      smart00219
      Location:356 → 619
      TyrKc; Tyrosine kinase, catalytic domain
      cd14066
      Location:357 → 629
      STKc_IRAK; Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs
      pfam01657
      Location:33 → 128
      Stress-antifung; Salt stress response/antifungal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9C5S9.1

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