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    SEC Tetratricopeptide repeat (TPR)-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819579, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SEC
    Official Full Name
    Tetratricopeptide repeat (TPR)-like superfamily protein
    Primary source
    TAIR:AT3G04240
    Locus tag
    AT3G04240
    See related
    Araport:AT3G04240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    secret agent; T6K12.14; T6K12_14
    Summary
    Has O-linked N-acetyl glucosamine transferase activity. Similar to Arabidopsis SPY gene.
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    Genomic context

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    See SEC in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    27
    Sequence:
    Chromosome: 3; NC_003074.8 (1113914..1120933, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Disease resistance protein (TIR-NBS-LRR class) family Neighboring gene ncRNA Neighboring gene Ribosomal protein S5 domain 2-like superfamily protein Neighboring gene F-box associated ubiquitination effector family protein Neighboring gene plastid transcriptionally active 3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SECRET AGENT O-GlcNAcylates Hundreds of Proteins Involved in Diverse Cellular Processes in Arabidopsis. Shrestha R, et al. Mol Cell Proteomics, 2024 Apr. PMID 38336175, Free PMC Article
    2. SECRET AGENT and SPINDLY have overlapping roles in the development of Arabidopsis thaliana L. Heyn. Hartweck LM, et al. J Exp Bot, 2006. PMID 16473894
    3. Two O-linked N-acetylglucosamine transferase genes of Arabidopsis thaliana L. Heynh. have overlapping functions necessary for gamete and seed development. Hartweck LM, et al. Genetics, 2002 Jul. PMID 12136030, Free PMC Article
    4. Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering. Xing L, et al. EMBO J, 2018 Oct 1. PMID 30150325, Free PMC Article
    5. O-GlcNAcylation of master growth repressor DELLA by SECRET AGENT modulates multiple signaling pathways in Arabidopsis. Zentella R, et al. Genes Dev, 2016 Jan 15. PMID 26773002, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SECRET AGENT O-GlcNAcylates Hundreds of Proteins Involved in Diverse Cellular Processes in Arabidopsis.
      Title: SECRET AGENT O-GlcNAcylates Hundreds of Proteins Involved in Diverse Cellular Processes in Arabidopsis.
    2. SEC transfers an O-GlcNAc group on Ser947 of ATX1, which resides in the SET domain, thereby activating ATX1. Taken together, these results uncover a novel post-translational O-GlcNAc modification-mediated mechanism for regulation of HKMT activity and establish the function of O-GlcNAc signaling in epigenetic processes in plants.
      Title: Arabidopsis O-GlcNAc transferase SEC activates histone methyltransferase ATX1 to regulate flowering.
    3. DELLAs are modified by the O-linked N-acetylglucosamine (O-GlcNAc) transferase (OGT) SECRET AGENT (SEC) in Arabidopsis.
      Title: O-GlcNAcylation of master growth repressor DELLA by SECRET AGENT modulates multiple signaling pathways in Arabidopsis.
    4. SECRET AGENT (SEC) functions in germination, rosette leaf growth, height of inflorescence stem, and the rate of production of rosette leaves.
      Title: SECRET AGENT and SPINDLY have overlapping roles in the development of Arabidopsis thaliana L. Heyn.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001337509.1
    NM_111295.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glycosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein O-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of flower development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein O-linked glycosylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Tetratricopeptide repeat (TPR)-like superfamily protein
    NP_187074.1
    • secret agent (SEC); CONTAINS InterPro DOMAIN/s: Tetratricopeptide TPR-1 (InterPro:IPR001440), Tetratricopeptide-like helical (InterPro:IPR011990), Tetratricopeptide repeat-containing (InterPro:IPR013026), Tetratricopeptide repeat (InterPro:IPR019734); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT3G11540.1); Has 114710 Blast hits to 35863 proteins in 2480 species: Archae - 3197; Bacteria - 54774; Metazoa - 16661; Fungi - 4580; Plants - 3873; Viruses - 0; Other Eukaryotes - 31625 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      1113914..1120933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_111295.4 → NP_187074.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187074.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M8Y0
      UniProtKB/TrEMBL
      A0A5S9X8Y4, A0A654F5D1, Q0WV85
      Conserved Domains (3) summary
      TIGR02917
      Location:54 → 487
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:257 → 285
      TPR; TPR repeat [structural motif]
      cl10013
      Location:508 → 944
      Glycosyltransferase_GTB-type; glycosyltransferase family 1 and related proteins with GTB topology

    2. NM_001337509.1 → NP_001326045.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VFL2, A0A1I9LN33, A0A384LLW5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M8Y0.1

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