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    DSK2 ubiquitin family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816225, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DSK2
    Official Full Name
    ubiquitin family protein
    Primary source
    TAIR:AT2G17200
    Locus tag
    AT2G17200
    See related
    Araport:AT2G17200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    DSK2b; T23A1.6; T23A1_6
    Summary
    Encodes a ubiquitin receptor protein that specifically associates with PEX2 and PEX12.
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    Genomic context

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    See DSK2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (7481881..7485240, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene C2H2-like zinc finger protein Neighboring gene ubiquitin family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene Protein kinase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival. Nolan TM, et al. Dev Cell, 2017 Apr 10. PMID 28399398, Free PMC Article
    2. Arabidopsis RING peroxins are E3 ubiquitin ligases that interact with two homologous ubiquitin receptor proteins(F). Kaur N, et al. J Integr Plant Biol, 2013 Jan. PMID 23336935
    3. The defective proteasome but not substrate recognition function is responsible for the null phenotypes of the Arabidopsis proteasome subunit RPN10. Lin YL, et al. Plant Cell, 2011 Jul. PMID 21764993, Free PMC Article
    4. Autophagic Degradation of the 26S Proteasome Is Mediated by the Dual ATG8/Ubiquitin Receptor RPN10 in Arabidopsis. Marshall RS, et al. Mol Cell, 2015 Jun 18. PMID 26004230, Free PMC Article
    5. Cross-species divergence of the major recognition pathways of ubiquitylated substrates for ubiquitin/26S proteasome-mediated proteolysis. Fatimababy AS, et al. FEBS J, 2010 Feb. PMID 20059542

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BES1 interacts with the ubiquitin receptor protein DSK2 and is targeted to the autophagy pathway during stress.
      Title: Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_127274.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables polyubiquitin modification-dependent protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin family protein
    NP_179311.1
    • DSK2; CONTAINS InterPro DOMAIN/s: Heat shock chaperonin-binding (InterPro:IPR006636), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Ubiquilin (InterPro:IPR015496), Ubiquitin (InterPro:IPR000626), Ubiquitin supergroup (InterPro:IPR019955), UBA-like (InterPro:IPR009060); BEST Arabidopsis thaliana protein match is: ubiquitin family protein (TAIR:AT2G17190.1); Has 15379 Blast hits to 7776 proteins in 854 species: Archae - 6; Bacteria - 3440; Metazoa - 5160; Fungi - 1735; Plants - 2506; Viruses - 174; Other Eukaryotes - 2358 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7481881..7485240 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127274.3 → NP_179311.1  ubiquitin family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179311.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94C51, Q9SII8
      UniProtKB/TrEMBL
      A0A5S9WYY8, A0A654EYL8
      Conserved Domains (4) summary
      smart00727
      Location:383 → 418
      STI1; Heat shock chaperonin-binding motif
      cd14399
      Location:508 → 547
      UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins
      TIGR00601
      Location:402 → 546
      rad23; UV excision repair protein Rad23
      cd16106
      Location:18 → 89
      Ubl_Dsk2p_like; ubiquitin-like (Ubl) domain found in Saccharomyces cerevisiae proteasome interacting protein Dsk2p and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SII8.1

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