FCA flowering time control protein FCA [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FCA
Official Full Name: flowering time control protein FCA
Primary source: TAIR:AT4G16280
Locus tag: AT4G16280
See related: Araport:AT4G16280
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BETA; DELTA AND GAMMA; DL4180C; FCAALL.331; FLOWERING TIME CONTROL PROTEIN FCA ALPHA
Summary: Involved in the promotion of the transition of the vegetative meristem to reproductive development. Four forms of the protein (alpha, beta, delta and gamma) are produced by alternative splicing. Involved in RNA-mediated chromatin silencing. At one point it was believed to act as an abscisic acid receptor but the paper describing that function was retracted.
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Genomic context

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See FCA in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 22

Sequence:: Chromosome: 4; NC_003075.7 (9206597..9214981, complement)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Antagonistic activities of cotranscriptional regulators within an early developmental window set FLC expression level.
Title: Antagonistic activities of cotranscriptional regulators within an early developmental window set FLC expression level.
R-loop resolution promotes co-transcriptional chromatin silencing.
Title: R-loop resolution promotes co-transcriptional chromatin silencing.
FCA binding of COOLAIR and SSU72 at FLC is critical for PRC2 enrichment and H3K27me3 deposition in Arabidopsis
Title: PRC2 recruitment and H3K27me3 deposition at FLC require FCA binding of COOLAIR.
an FCA-mediated epigenetic route towards thermal adaptation of autotrophic development in plants
Title: An FCA-mediated epigenetic route towards thermal adaptation of autotrophic development in plants.
regulation of YUC8 expression tunes down PIF4-induced architectural changes to achieve thermal adaptation of stem growth at high ambient temperature
Title: FCA mediates thermal adaptation of stem growth by attenuating auxin action in Arabidopsis.
FCA plays a role in the induction of thermotolerance by triggering antioxidant accumulation under heat stress conditions.
Title: The Arabidopsis thaliana RNA-binding protein FCA regulates thermotolerance by modulating the detoxification of reactive oxygen species.
Data suggest that the FCA-miR172 regulon provides an adaptive strategy that fine tunes the onset of flowering under fluctuating ambient temperature conditions.
Title: Arabidopsis RNA-binding protein FCA regulates microRNA172 processing in thermosensory flowering.
FCA and FPA play important roles in the A. thaliana genome in RNA 3' processing and transcription termination, thus limiting intergenic transcription.
Title: RNA 3' processing functions of Arabidopsis FCA and FPA limit intergenic transcription.
Data show distinct layers of FCA regulation that involve sequences within the 5' region that regulate noncanonical translation initiation and alter the expression profile.
Title: Noncanonical translation initiation of the Arabidopsis flowering time and alternative polyadenylation regulator FCA.
FCA does not bind ABA
Title: FCA does not bind abscisic acid.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001341092.1

Supported by ESTs:

NM_117725.3

Supported by ESTs:

NM_148347.2

Supported by ESTs:

NM_179211.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
NOT enables abscisic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryo sac development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulatory ncRNA-mediated heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: flowering time control protein FCA

NP_001319956.1

FCA; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Ribonucleoprotein, BRUNO-like (InterPro:IPR015903), WW/Rsp5/WWP (InterPro:IPR001202), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: flowering time control protein-related / FCA gamma-related (TAIR:AT2G47310.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_193363.4

FCA; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Ribonucleoprotein, BRUNO-like (InterPro:IPR015903), Paraneoplastic encephalomyelitis antigen (InterPro:IPR002343), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: flowering time control protein-related / FCA gamma-related (TAIR:AT2G47310.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NP_680713.2

RNA binding;abscisic acid binding; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), WW/Rsp5/WWP (InterPro:IPR001202), Ribonucleoprotein, BRUNO-like (InterPro:IPR015903), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: flowering time control protein-related / FCA gamma-related (TAIR:AT2G47310.1).

NP_849542.2

FCA; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Ribonucleoprotein, BRUNO-like (InterPro:IPR015903), WW/Rsp5/WWP (InterPro:IPR001202), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: flowering time control protein-related / FCA gamma-related (TAIR:AT2G47310.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

9206597..9214981 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_148347.2 → NP_680713.2 flowering time control protein FCA [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UWV8, F4JLR7, Q5I5A2

Conserved Domains (3) summary

cd00201
Location:522 → 549

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd12633
Location:46 → 125

RRM1_FCA; RNA recognition motif 1 in plant flowering time control protein FCA and similar proteins

cd12637
Location:137 → 216

RRM2_FCA; RNA recognition motif 2 in plant flowering time control protein FCA and similar proteins
NM_001341092.1 → NP_001319956.1 flowering time control protein FCA [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JLR8, F4JLR9, O04424, O04425, O04727, O23475

UniProtKB/TrEMBL

A0A178UWV8, Q5I5A2

Conserved Domains (4) summary

cd00201
Location:597 → 624

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cd12633
Location:121 → 200

RRM1_FCA; RNA recognition motif 1 in plant flowering time control protein FCA and similar proteins

cd12637
Location:212 → 291

RRM2_FCA; RNA recognition motif 2 in plant flowering time control protein FCA and similar proteins

cl25617
Location:121 → 497

LSM_int_assoc; LSM-interacting associated unstructured
NM_117725.3 → NP_193363.4 flowering time control protein FCA [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_193363.4

Status: REVIEWED

UniProtKB/Swiss-Prot

O04425

Conserved Domains (2) summary

cd12633
Location:121 → 200

RRM1_FCA; RNA recognition motif 1 in plant flowering time control protein FCA and similar proteins

cd12637
Location:212 → 291

RRM2_FCA; RNA recognition motif 2 in plant flowering time control protein FCA and similar proteins
NM_179211.3 → NP_849542.2 flowering time control protein FCA [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849542.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A178UV10

Conserved Domains (2) summary

cd00201
Location:355 → 382

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

cl17169
Location:1 → 49

RRM_SF; RNA recognition motif (RRM) superfamily