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    HSBP heat shock factor binding protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827261, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HSBP
    Official Full Name
    heat shock factor binding protein
    Primary source
    TAIR:AT4G15802
    Locus tag
    AT4G15802
    See related
    Araport:AT4G15802
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana heat shock factor binding protein; AtHSBP; heat shock factor binding protein
    Summary
    Encodes a protein with similarity to heat shock factor binding proteins. Involved in negative regulation of heat shock response. Becomes nuclear localized upon heat treatment.
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    Genomic context

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    See HSBP in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (8986598..8988661, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uveal autoantigen with coiled-coil/ankyrin Neighboring gene ralf-like 33 Neighboring gene ncRNA Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene ABC subfamily C protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis HEAT SHOCK FACTOR BINDING PROTEIN is required to limit meiotic crossovers and HEI10 transcription. Kim J, et al. EMBO J, 2022 Jul 18. PMID 35670129, Free PMC Article
    2. AtHSBP functions in seed development and the motif is required for subcellular localization and interaction with AtHSFs. Hsu SF, et al. Plant Signal Behav, 2010 Aug. PMID 20657173, Free PMC Article
    3. Cytosol-localized heat shock factor-binding protein, AtHSBP, functions as a negative regulator of heat shock response by translocation to the nucleus and is required for seed development in Arabidopsis. Hsu SF, et al. Plant Physiol, 2010 Jun. PMID 20388662, Free PMC Article
    4. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Parsons HT, et al. Plant Physiol, 2012 May. PMID 22430844, Free PMC Article
    5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The defective AtHSBP may not affect ovule development but may influence embryogenesis after fertilization to result in seed abortion.
      Title: AtHSBP functions in seed development and the motif is required for subcellular localization and interaction with AtHSFs.
    2. AtHSBP functions as a negative regulator of heat shock response and is required for seed development.
      Title: Cytosol-localized heat shock factor-binding protein, AtHSBP, functions as a negative regulator of heat shock response by translocation to the nucleus and is required for seed development in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_179061.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular heat acclimation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to heat IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in seed development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    heat shock factor binding protein
    NP_849392.4
    • heat shock factor binding protein (HSBP); CONTAINS InterPro DOMAIN/s: Heat shock factor binding 1 (InterPro:IPR009643); Has 319 Blast hits to 319 proteins in 108 species: Archae - 0; Bacteria - 0; Metazoa - 183; Fungi - 14; Plants - 74; Viruses - 0; Other Eukaryotes - 48 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      8986598..8988661 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179061.5 → NP_849392.4  heat shock factor binding protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849392.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23431, Q8GW48
      UniProtKB/TrEMBL
      A0A654FPN1
      Conserved Domains (1) summary
      pfam06825
      Location:14 → 64
      HSBP1; Heat shock factor binding protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GW48.1

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